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The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination

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Figure

Figure 1: Generation of the Herc2allele and the designed primers to identify both alleles (left)
Figure 2: Analysis of progeny from the Herc2development. Lysates from brains at different stages were analyzed by immunoblotting for HERC2 and β-actin
Figure 3: p53 inactivation did not rescue the lethality of Herc2530/530 homozygous mice
Figure 4: Herc2using specific antibodies against HERC2 in several tissues from 8 week old mice
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