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RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche

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Academic year: 2020

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Figure

Fig. 1. Testis weights are significantly increased in non-atrophicknockout mice. (A) Body weights are not significantly altered in control(Rbpjfl/fl) and RbpjSCKO (Amh-cre;Rbpjfl/fl) mice throughout adulthood.(B) Non-atrophic testis weights are significant
Fig. 2. Tubule diameter and epithelial thickness are significantly increased in non-atrophic RbpjSCKO mice
Fig. 3. Increase in testis weight is associated with an increase in number of germ cells, whereas the total number of Sertoli cells is unchanged inRbpjround spermatids and pachytene spermatocytes, respectively
Fig. 4. The expression of Sertoli cell-expressed genes that are required for germ cell maintenance and differentiation is regulated by NOTCH signaling.Quantitative RT-PCR analysis of whole fetal (E14.5) overexpressor (Amh-cre;RosaNICD/+) and control (RosaN
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