1-(5-BROMOBENZOFURAN-2-YL) ETHANONE OXIME

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Crystal structure of 1 (5 bromo 1 benzo­furan 2 yl)ethanone oxime

Crystal structure of 1 (5 bromo 1 benzo­furan 2 yl)ethanone oxime

deviation for the non-H atoms = 0.031 A ˚ ) and the conforma- tion across the C N bond is trans. Further, the O atom of the benzofuran ring is syn to the N atom of the oxime group. In the crystal, inversion dimers linked by pairs of O—H N hydrogen bonds generate R 2 2 (6) loops. Very weak aromatic –

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1 (3 Methyl 3 phenyl­cyclo­butyl) 2 (piperidin 1 yl)ethanone oxime

1 (3 Methyl 3 phenyl­cyclo­butyl) 2 (piperidin 1 yl)ethanone oxime

3-Substituted cyclobutanecarboxylic acid derivatives exhibit anti-inflammatory and antidepressant activities (Dehmlow & Schmidt, 1990), and also liquid crystal properties (Coghi et al., 1976). Owing to their unique biological properties, piperidines have been target molecules in organic synthesis (Weintraub et al., 2003). In recent years, polyhydroxylated piperidine alka- loids have attracted much attention because some of them have the ability to act as selective glycosidase inhibitors (Stutz, 1999). Oximes show geometric isomerism due to the double bond between the N and C atoms (Mixich & Thiele, 1979; Migrdichian, 1957). As there are significant differences in the physical, chemical and biological properties of these geometric isomers, the determination of the configuration of the isomers is important (Mathison et al., 1989). Oximes and oxime ethers also have a broad pharmacological activity spectrum, encompassing antifungal, antibacterial, antidepressant and insecticidal activities, as well as activity as nerve-gas antidotes, depending on the pharmacophoric group of the molecule (Polak, 1982; Balsamo et al., 1990; Holan et al., 1984; Forman, 1964). The oxime group (C N—OH) possesses stronger hydrogen-bonding capabilities than the alcohol, phenol or carboxylic acid group (Marsman et al., 1999). Hydrogen bonding plays a key role in molecular recognition in chemical engineering (Bertolasi et al., 1982; Gilli et al., 1983; Ho¨kelek et al., 2001). As part of our ongoing study of the relationship between the structures of cyclobutane and oxime derivatives, a crystal structure determination of the title compound, (I), has been undertaken and the results are presented here.

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(E) 1 (4 Amino­phen­yl)ethanone oxime

(E) 1 (4 Amino­phen­yl)ethanone oxime

For the preparation of the title compound, a solution of 1-(4-aminophenyl)- ethanone (1.35 g, 10 mmol) in methanol (15 ml) was added to a mixture of hydroxylamine sulfate (1.31 g, 10 mmol) and sodium acetate (2.0 g, 25 mmol). The reaction mass was refluxed for 4-5 h, until the reaction completed. The solvent was evaporated under vacuo and demineralized water (40 ml) was added, cooled to 268-265 K and filtered to obtain crystalline solid (yield; 1.11 g, 75%; m.p. 401-402 K).

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Bis(formato κO)bis­­[1 (pyridin 2 yl)ethanone oxime κ2N,N′]nickel(II)

Bis(formato κO)bis­­[1 (pyridin 2 yl)ethanone oxime κ2N,N′]nickel(II)

C1 0.051 (3) 0.095 (3) 0.037 (2) 0.004 (2) 0.022 (2) 0.012 (2) C2 0.0305 (19) 0.062 (3) 0.033 (2) −0.0076 (18) 0.0172 (17) 0.0042 (17) C3 0.035 (2) 0.055 (2) 0.044 (2) 0.0015 (17) 0.0258 (18) 0.0078 (18) C4 0.052 (3) 0.077 (3) 0.058 (3) 0.014 (2) 0.034 (2) 0.020 (2) C5 0.071 (3) 0.078 (3) 0.091 (4) 0.033 (3) 0.059 (3) 0.026 (3) C6 0.080 (3) 0.074 (3) 0.083 (4) 0.012 (3) 0.066 (3) 0.000 (3) C7 0.055 (2) 0.063 (3) 0.050 (2) 0.007 (2) 0.039 (2) 0.003 (2) C8 0.056 (3) 0.087 (3) 0.032 (2) −0.012 (2) 0.024 (2) −0.012 (2) C9 0.0332 (19) 0.052 (2) 0.0245 (17) 0.0053 (17) 0.0151 (16) −0.0010 (15) C10 0.0371 (19) 0.045 (2) 0.0356 (19) 0.0024 (16) 0.0237 (17) −0.0014 (16) C11 0.045 (2) 0.058 (3) 0.039 (2) −0.0116 (18) 0.0237 (18) −0.0149 (18) C12 0.058 (3) 0.057 (3) 0.064 (3) −0.019 (2) 0.044 (2) −0.012 (2) C13 0.062 (3) 0.057 (3) 0.049 (2) −0.011 (2) 0.040 (2) −0.0053 (19) C14 0.042 (2) 0.054 (2) 0.0329 (19) −0.0052 (17) 0.0250 (18) −0.0043 (17) C15 0.052 (3) 0.057 (3) 0.077 (3) −0.002 (2) 0.045 (3) −0.011 (2) C16 0.042 (2) 0.050 (2) 0.062 (3) 0.0012 (18) 0.032 (2) 0.008 (2)

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(1Z) 1 (1 Benzo­furan 2 yl)ethanone oxime

(1Z) 1 (1 Benzo­furan 2 yl)ethanone oxime

2-Acetylbenzofuran (0.0062 mmol), hydroxyaminehydrochloride (0.0093 mmol) and anhydrous potassium carbonate (0.0093 mmol) were taken in a round bottom flask containing ethanol and water taken in the ratio 3:1. The reaction mixture was refluxed for 3 hrs·The progress of the reaction was monitored by thin layer chromatography. The reaction mixture was poured into ice cold water. The title compound separated as white solid. It was filtered, washed with water, dried and recrystallized from ethanol.

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1 (2′,4′ Di­fluoro­bi­phenyl 4 yl)ethanone

1 (2′,4′ Di­fluoro­bi­phenyl 4 yl)ethanone

F3 0.070 (2) 0.090 (2) 0.086 (3) −0.0063 (16) 0.028 (2) −0.0042 (19) F4 0.0778 (19) 0.0526 (13) 0.090 (2) 0.0200 (13) 0.0111 (16) 0.0100 (15) O2 0.064 (2) 0.073 (2) 0.109 (3) −0.0153 (18) 0.018 (2) 0.004 (2) C15 0.039 (2) 0.063 (2) 0.056 (3) −0.0044 (16) 0.009 (2) −0.007 (2) C16 0.066 (3) 0.050 (2) 0.058 (2) −0.0070 (19) 0.004 (2) −0.001 (2) C17 0.052 (2) 0.0434 (19) 0.055 (2) 0.0069 (15) 0.0025 (19) −0.0022 (18) C18 0.0430 (19) 0.0475 (19) 0.044 (2) 0.0043 (16) 0.0007 (16) −0.0034 (18) C19 0.045 (2) 0.051 (2) 0.065 (3) 0.0059 (17) 0.0014 (19) 0.002 (2) C20 0.048 (2) 0.061 (2) 0.065 (3) 0.0073 (19) 0.006 (2) −0.005 (2) C21 0.0419 (18) 0.0474 (19) 0.044 (2) 0.0023 (15) −0.0027 (16) −0.0017 (18) C22 0.057 (2) 0.0421 (19) 0.063 (3) 0.0021 (16) 0.002 (2) −0.0096 (19) C23 0.051 (2) 0.048 (2) 0.062 (3) −0.0059 (16) −0.0004 (19) −0.0085 (19) C24 0.0408 (18) 0.0514 (19) 0.047 (2) 0.0007 (15) −0.0013 (17) 0.0041 (17) C25 0.052 (2) 0.057 (2) 0.053 (2) 0.001 (2) 0.0037 (19) −0.013 (2) C26 0.0461 (19) 0.050 (2) 0.055 (2) −0.0055 (16) 0.0019 (18) −0.0084 (19) C27 0.050 (2) 0.069 (3) 0.058 (3) −0.0011 (19) 0.000 (2) 0.002 (2)

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1 [2 (1,3 Benzo­thia­zol 2 ylimino)imidazolidin 1 yl]ethanone

1 [2 (1,3 Benzo­thia­zol 2 ylimino)imidazolidin 1 yl]ethanone

The atom-numbering scheme of the title compound, (3), is shown in Fig. 1. With the exception of seven H atoms, (3) is planar. The S1—C1 [1.7338 (15) A ˚ ] and S1—C7 [1.7654 (13) A ˚ ] bond distances are in agreement with those in similar compounds (Aydın et al., 2002; Akkurt et al., 2005). The N2 C8 bond distance [1.3053 (16) A ˚ ] and the N2—C7 bond length [1.3589 (17) A ˚ ] are normal for N Csp 2 and N— Csp 2 bond lengths in related compounds (Cambridge Struc- tural Database; Version 5.27; Allen, 2002).

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1 (2H 1,3 Benzodioxol 5 yl)ethanone thio­semicarbazone

1 (2H 1,3 Benzodioxol 5 yl)ethanone thio­semicarbazone

N1 0.0320 (7) 0.0199 (6) 0.0367 (8) 0.0067 (5) −0.0014 (6) −0.0073 (5) C1 0.0269 (7) 0.0175 (6) 0.0227 (7) 0.0036 (5) 0.0060 (6) 0.0011 (5) S1 0.0335 (3) 0.0145 (2) 0.0383 (3) 0.00688 (13) 0.00280 (18) −0.00235 (13) N2 0.0285 (7) 0.0133 (6) 0.0287 (7) 0.0050 (4) 0.0022 (5) −0.0034 (4) N3 0.0278 (6) 0.0128 (5) 0.0255 (6) 0.0044 (4) 0.0049 (5) −0.0015 (4) C2 0.0231 (7) 0.0162 (6) 0.0226 (7) 0.0011 (5) 0.0079 (6) −0.0007 (5) C3 0.0258 (8) 0.0250 (7) 0.0475 (10) −0.0039 (6) 0.0101 (7) −0.0084 (6) C4 0.0220 (7) 0.0168 (6) 0.0204 (6) 0.0039 (5) 0.0056 (5) 0.0008 (5) C5 0.0219 (7) 0.0230 (7) 0.0363 (8) 0.0034 (5) 0.0073 (6) 0.0012 (6) C6 0.0251 (7) 0.0269 (8) 0.0429 (9) 0.0116 (6) 0.0095 (7) 0.0044 (6) C7 0.0331 (8) 0.0172 (7) 0.0246 (7) 0.0099 (5) 0.0092 (6) 0.0030 (5) O1 0.0434 (7) 0.0165 (5) 0.0473 (7) 0.0112 (4) 0.0129 (6) 0.0045 (4) C8 0.0487 (10) 0.0156 (7) 0.0349 (9) 0.0047 (6) 0.0145 (8) 0.0013 (6) O2 0.0333 (6) 0.0141 (5) 0.0703 (9) −0.0002 (4) 0.0100 (6) −0.0022 (5) C9 0.0262 (7) 0.0161 (6) 0.0281 (7) 0.0012 (5) 0.0064 (6) −0.0006 (5) C10 0.0209 (7) 0.0170 (7) 0.0324 (8) 0.0043 (5) 0.0058 (6) −0.0006 (5)

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1 [1 (4 Fluoro­phen­yl) 2 methyl 5 phenyl 1H pyrrol 3 yl]ethanone

1 [1 (4 Fluoro­phen­yl) 2 methyl 5 phenyl 1H pyrrol 3 yl]ethanone

The title compound was synthesized according to the procedure reported in the literature (Nagarajan et al., 1985) and subsequently tested for anti-implantation activity. The compound was crystallized from solutions in dichloromethane and hexane (2:1, v/v) by slow evaporation at 278 K.

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1 (1 Benzyl 1H benzimidazol 2 yl)ethanone

1 (1 Benzyl 1H benzimidazol 2 yl)ethanone

C14 0.095 (3) 0.076 (2) 0.046 (2) 0.040 (2) 0.0195 (19) 0.0160 (17) C15 0.058 (2) 0.067 (2) 0.057 (2) 0.0204 (17) 0.0105 (16) −0.0019 (17) N3 0.0403 (13) 0.0476 (13) 0.0287 (11) 0.0178 (11) 0.0051 (9) 0.0045 (9) N4 0.0401 (13) 0.0428 (13) 0.0325 (12) 0.0188 (10) 0.0039 (10) 0.0037 (9) C25 0.0363 (14) 0.0391 (14) 0.0344 (14) 0.0136 (12) 0.0019 (11) 0.0017 (11) C20 0.0379 (14) 0.0357 (13) 0.0296 (13) 0.0130 (11) 0.0022 (11) 0.0015 (10) O2 0.0567 (14) 0.0883 (17) 0.0514 (14) 0.0436 (13) 0.0108 (11) −0.0015 (12) C19 0.0355 (14) 0.0406 (14) 0.0349 (14) 0.0149 (12) 0.0010 (11) 0.0024 (11) C27 0.0492 (17) 0.0603 (18) 0.0256 (13) 0.0303 (14) 0.0049 (12) 0.0091 (12) C21 0.0478 (17) 0.0451 (16) 0.0370 (15) 0.0205 (13) 0.0069 (12) 0.0013 (12) C26 0.0446 (17) 0.0598 (18) 0.0353 (15) 0.0181 (14) 0.0120 (13) 0.0125 (13) C18 0.0364 (15) 0.0513 (17) 0.0436 (17) 0.0190 (13) −0.0001 (13) −0.0014 (13) C24 0.0523 (18) 0.0495 (16) 0.0349 (15) 0.0219 (14) −0.0015 (13) 0.0072 (12) C17 0.0552 (19) 0.0553 (18) 0.0538 (19) 0.0334 (16) 0.0008 (15) 0.0070 (14) C28 0.062 (2) 0.092 (3) 0.0353 (16) 0.046 (2) 0.0044 (15) 0.0034 (16) C32 0.0486 (18) 0.065 (2) 0.0413 (16) 0.0274 (16) 0.0057 (13) 0.0009 (14) C23 0.0519 (18) 0.0477 (17) 0.0516 (18) 0.0275 (14) −0.0025 (14) 0.0054 (14) C22 0.0525 (18) 0.0511 (17) 0.0502 (18) 0.0288 (15) 0.0056 (14) −0.0019 (14) C31 0.058 (2) 0.071 (2) 0.057 (2) 0.0253 (18) −0.0066 (17) 0.0025 (17) C29 0.095 (3) 0.099 (3) 0.0431 (19) 0.063 (3) −0.0003 (19) −0.0115 (19) C30 0.089 (3) 0.079 (3) 0.050 (2) 0.043 (2) −0.0192 (19) −0.0122 (18)

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1 (1 Benzo­furan 2 yl)ethanone O (2,6 di­fluoro­benz­yl)oxime

1 (1 Benzo­furan 2 yl)ethanone O (2,6 di­fluoro­benz­yl)oxime

The molecular structure of the title compound and the atom-labelling scheme is illustrated in Fig. 1. In this compound, the nine-membered benzofuran system is planar with an r.m.s. deviation of 0.0083 Å. The 2,6-difluorobenzyloxy moiety is in the E configuration with respect to the benzofuran system [torsion angle C2—C10—N12—O13: 178.89 (9)°]. The C10—N12 bond is antiperiplanar in relation to the O13—C14 bond [torsion angle C10—N12—O13—C14:

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NEW APPROACHES OF 4 ARYL 2 HYDRAZINOTHIAZOLE DERIVATIVES SYNTHESIS, MOLECULAR DOCKING, AND BIOLOGICAL EVALUATIONS

NEW APPROACHES OF 4 ARYL 2 HYDRAZINOTHIAZOLE DERIVATIVES SYNTHESIS, MOLECULAR DOCKING, AND BIOLOGICAL EVALUATIONS

a) Antibacterial: Table 3 and Fig. 1, showed in- vitro experiment for the mean of antimicrobial effects on g-positive bacteria (SA), that revealed the effect of this dissolved substances as antimicrobial (antibacterial) and were done in the hrs of exposures included (1, 3, 5 and 7h). The mean antimicrobial effects were calculated during the exposure hrs, and the averages were in descending order by the percentage of the antibacterial as illustrated in Table 3 and Fig. 1. Bacteria had developed resistance strains against currently available antimicrobial agents, synthesize novel antimicrobial less toxicity and more potent effects in much lesser time. The shining examples are Furamizole, Nasapadil, Tazobactam, and Cefatrizine. Benzimidazoles have various types of pharmacological effects, including antimicrobial 22,

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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL INDOLE DERIVATIVES

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL INDOLE DERIVATIVES

Recent literatures suggest that several indole-3-substituted derivatives were synthesized using acid catalysed Michael addition,29 Mannich reaction,30 multi component coupling reaction,31 etc. Number of alkaloids, agrochemicals, pharmaceuticals and perfumes had been synthesized using several 3substituited indoles as starting materials. In the present work, we have developed indole-3-yl derivatives using Knoevenagel reaction, which get acetylated with simple acetyl chloride to give 1acetyl-1H-indol-3-yl derivatives. All the synthesized compounds were characterized by 1H- NMR, LCMS, FT-IR and UV-Visible spectroscopy. A large number of heterocyclic compounds containing the indole ring are associated with diverse pharmacological properties such as Analgesic, Anti-allergic, Antibacterial, Anticonvulsant, Antifungal, Antihistaminic, Antiinflammatory,

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2 Bromo 1 [1 (4 bromo­phen­yl) 5 methyl 1H 1,2,3 triazol 4 yl]ethanone

2 Bromo 1 [1 (4 bromo­phen­yl) 5 methyl 1H 1,2,3 triazol 4 yl]ethanone

compounds (Danence et al. 2011; Zeghada et al. 2011; Abdel-Wahab, Abdel-Latif et al. 2013; Abdel-Wahab, Mohamed et al. 2013). The 2-bromo-1-ethanone substituent in the molecules of I has a significantly flattened conformation (the Br– C–C═O torsion angles are 1.2 (4) and -2.8 (4)° for the two independent molecules, respectively), with the carbonyl group directed toward the methyl substituent, and lies almost within the triazole plane (r.m.s. deviations are 0.037 and 0.023 Å for the two independent molecules, respectively) (Figure 2). The bromo-benzene substituent is twisted by 52.30 (6) and 51.81 (6)° (for the two independent molecules, respectively) relative to this main plane of the molecule.

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1 {3 (4 Chloro­phen­yl) 5 [4 (propan 2 yl)phen­yl] 4,5 di­hydro 1H pyrazol 1 yl}ethanone

1 {3 (4 Chloro­phen­yl) 5 [4 (propan 2 yl)phen­yl] 4,5 di­hydro 1H pyrazol 1 yl}ethanone

To a mixture of (2E)-1-(4-chlorophenyl)-3-[4-(propan-2-yl) phenyl] prop-2-en-1-one (2.85g, 0.01 mol) and hydrazine hydrate (0.5mL, 0.01 mol) in 25 mL acetic acid was refluxed for 9h (Fig. 3). The reaction mixture was cooled and poured into ice-cold water. The precipitate formed was collected by filtration and purified by recrystallization from ethanol. Colourless, irregular, crystals were grown from ethanol solution by the slow evaporation method (m.p.: 389–391 K). S3. Refinement

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2 (2,3 Di­methyl­phen­­oxy) 1 (pyridin 2 yl) 2 (1H 1,2,4 triazol 1 yl)ethanone

2 (2,3 Di­methyl­phen­­oxy) 1 (pyridin 2 yl) 2 (1H 1,2,4 triazol 1 yl)ethanone

N1 0.0427 (10) 0.0571 (11) 0.0768 (13) 0.0144 (9) 0.0243 (9) 0.0133 (9) N2 0.0417 (9) 0.0467 (10) 0.0522 (10) 0.0106 (8) 0.0198 (8) 0.0186 (8) N3 0.0458 (10) 0.0725 (13) 0.0590 (12) 0.0058 (9) 0.0110 (9) 0.0227 (10) N4 0.0707 (13) 0.0804 (14) 0.0664 (13) 0.0140 (11) 0.0263 (11) 0.0378 (11) C1 0.0522 (14) 0.0752 (18) 0.0939 (19) 0.0244 (13) 0.0310 (13) 0.0162 (14) C2 0.0832 (19) 0.0765 (19) 0.0928 (19) 0.0466 (16) 0.0441 (16) 0.0291 (15) C3 0.113 (2) 0.0545 (15) 0.111 (2) 0.0394 (16) 0.0599 (19) 0.0277 (15) C4 0.0825 (18) 0.0515 (15) 0.0919 (18) 0.0182 (13) 0.0465 (15) 0.0273 (13) C5 0.0492 (12) 0.0463 (12) 0.0514 (12) 0.0147 (10) 0.0186 (10) 0.0194 (9) C6 0.0422 (11) 0.0486 (12) 0.0557 (13) 0.0115 (10) 0.0181 (10) 0.0208 (10) C7 0.0381 (10) 0.0485 (12) 0.0505 (12) 0.0129 (9) 0.0189 (9) 0.0172 (9) C8 0.0513 (12) 0.0641 (14) 0.0669 (15) 0.0076 (11) 0.0245 (12) 0.0294 (12) C9 0.0640 (16) 0.0756 (16) 0.0565 (15) 0.0133 (13) 0.0146 (12) 0.0243 (12) C10 0.0455 (11) 0.0407 (11) 0.0395 (11) 0.0109 (9) 0.0167 (9) 0.0123 (8) C11 0.0454 (12) 0.0575 (14) 0.0613 (14) 0.0073 (11) 0.0201 (10) 0.0139 (11) C12 0.0602 (15) 0.0546 (15) 0.0704 (16) −0.0039 (12) 0.0232 (12) 0.0073 (12) C13 0.0843 (18) 0.0411 (12) 0.0627 (15) 0.0102 (13) 0.0257 (13) 0.0069 (10) C14 0.0613 (14) 0.0509 (13) 0.0457 (12) 0.0173 (11) 0.0191 (10) 0.0134 (10) C15 0.0861 (19) 0.0667 (16) 0.103 (2) 0.0377 (15) 0.0391 (16) 0.0157 (15) C16 0.0442 (11) 0.0490 (12) 0.0347 (10) 0.0118 (9) 0.0131 (9) 0.0140 (9) C17 0.0442 (12) 0.0638 (14) 0.0618 (14) 0.0144 (11) 0.0195 (10) 0.0178 (11)

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1 (2 Hydr­­oxy 5 methyl­phen­yl)ethanone [(1H indol 3 ­yl)acet­yl]hydrazone

1 (2 Hydr­­oxy 5 methyl­phen­yl)ethanone [(1H indol 3 ­yl)acet­yl]hydrazone

In the similar synthesis but with 2-hydroxy-5-methylacetophenone, only the pure Schiff base is obtained (Scheme I, Fig. 1). The indolyl –NH unit forms a hydrogen bond to the –OH unit of an inversion-related molecule to furnish a hydrogen- bonded dimer; adjacent dimers are further linked through an inter-dimer N–H···O hydrogen involving the –C(=O)–NH– N= fragment to form a linear ribbon chain that runs along the shortest axis of the triclinic unit cell (Fig. 2). The hydroxy group itself engages in intramolecular hydrogen bonding.

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2 Chloro 1 [4 (2 fluoro­benz­yl)piperazin 1 yl]ethanone

2 Chloro 1 [4 (2 fluoro­benz­yl)piperazin 1 yl]ethanone

Herein, we report the synthesis of the title compound as one important representative of piperazine derivatives and its X-ray crystal structure. The molecule of (I) is shown in Fig. 1. The bond lengths and angles are within normal ranges. The piperazine ring in the molecule adopts a chair conformation. The dihedral angle between the fluorophenyl ring and the four planar C atoms (r.m.s. = 0.0055 Å) of the piperazine chair is 78.27 (7)°. Whereas the dihedral angle between the four planar C atoms of the piperazine chair and the ethanone plane is 55.21 (9)Å with the Cl atom about 1.589 (2) Å out of plane. In the crystal, there are no strong intermolecular hydrogen bonds to link the molecules.

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Synthesis and anticonvulsant activity of 1 [(4, 5 dihydro 5 phenyl 3 (phenylamino)pyrazol 1 yl)]ethanone derivatives

Synthesis and anticonvulsant activity of 1 [(4, 5 dihydro 5 phenyl 3 (phenylamino)pyrazol 1 yl)]ethanone derivatives

The reaction scheme is as figure 1. All Melting points (m.p.) were determined in open capillaries on Jindal melting point apparatus and are uncorrected. The purity of the compounds was routinely checked by thin layer chromatography (TLC) using silica gel G (Merck). The instruments used for spectroscopic data are IR: Jasco IR-470 spectrophotometer (KBr) with diffuse reflectance method; MS-JEOL SX102 Mass spectroscopy by using Argon/Xenone (6Kv, 10mA) as the FAB gas and m-nitro benzyl alcohol (NBA) as the matrix. H 1 NMR: JEOL GSX- 400, 60MHz spectrometer in CDCl 3 , TMS (tetra methyl saline) as an internal standard.

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1 (1 Benzo­furan 2 yl)ethanone O (2 chloro­benzo­yl)oxime

1 (1 Benzo­furan 2 yl)ethanone O (2 chloro­benzo­yl)oxime

For the synthesis of (I), 2-acetylbenzofuranoxime (1.75 g, 10 mmol), triethylamine (2 ml) and dry THF (100 ml) were stirred at room temperature for 1 h. To this solution, 2-chlorobenzoylchloride (1.75 g, 10 mmol) was added dropwise and the mixture was stirred for another 1 h at room temperature. The reaction mixture was poured into water (250 ml) and precipitated twice from water. The solid was filtered off and recrystallized from acetone. Yield 2.92 g, 93.3%.

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