3T3-L1 adipocytes
Lipolytic Effect of Eumicrotremus orbis Water Extracts in Differentiated 3T3-L1 Adipocytes
... differentiated 3T3-L1 adipocytes, the protein expression of ATGL was examined, as shown in ...the adipocytes is mainly dependent on cellular expression of lipase such as HSL and ...
6
Extract of Paecilomyces hepiali mycelia induces lipolysis through PKA mediated phosphorylation of hormone sensitive lipase and ERK mediated downregulation of perilipin in 3T3 L1 adipocytes
... In summary, the present data demonstrate that metha- nol extract from mycelia of Paecilomyces hepiali induced HSL phosphorylation and decreased perilipin level, therefore increased lipolysis in fully differentiated ...
10
Chronic endothelin 1 treatment leads to heterologous desensitization of insulin signaling in 3T3 L1 adipocytes
... IRS-1 and the other IRS family members are major substrates of the insulin receptor, which, when tyrosine phosphorylated, serve as docking proteins for SH2 domain containing proteins (12, 13). The SH2 domains of the p85 ...
11
Suppressive actions of eicosapentaenoic acid on lipid droplet formation in 3T3-L1 adipocytes
... EPA, being the predominant long chain n-3 PUFA found in marine oils, suppresses LD formation and size in 3T3- L1 adipocytes, in comparison to other FAs. Several lines of evidence suggest a beneficial ...
8
In vitro anti-diabetic effect of flavonoids and pheophytins from Allophylus cominia Sw. on the glucose uptake assays by HepG2, L6, 3T3-L1 and fat accumulation in 3T3-L1 adipocytes
... in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal ...
24
mVps45 knockdown selectively modulates VAMP expression in 3T3-L1 adipocytes
... I nsulin stimulates the delivery of glucose transporter-4 (GLUT4)-containing vesicles to the surface of adipocytes. Deple- tion of the Sec1/Munc18 protein mVps45 significantly abrogates insulin-stimulated glucose ...
5
Anti adipogenic effects of the traditional herbal formula Dohongsamul tang in 3T3 L1 adipocytes
... 26. Liang X, Kanjanabuch T, Mao SL, Hao CM, Tang YW, Declerck PJ, Hasty AH, Wasserman DH, Fogo AB, Ma LJ. Plasminogen activator inhibitor-1 modulates adipocyte differentiation. Am J Physiol Endocrinol Metab. ...
10
Characterization of VAMP isoforms in 3T3-L1 adipocytes : implications for GLUT4 trafficking
... Paradoxically, other studies have suggested that many SNARE- mediated trafficking events use multiple v-SNAREs (e.g., Liu and Barlowe, 2002), suggesting functional redundancy at the level of VAMPs (Yang et al., 1999). In ...
7
Development of a Novel Anti-Obesity Compound with Inhibiting Properties on the Lipid Accumulation in 3T3-L1 Adipocytes
... Another effective active ingredient in the adipogenesis inhibition, investigated in the present research, was capsaicin, which was used at the doses of 6.25 μM and 12.5 μM. Previous studies have revealed that capsaicin ...
9
An Herbal Formula LI85008F Inhibits Lipogenesis in 3T3 L1 Adipocytes
... in adipocytes, which is synergistically better than the activities of the individual extracts (Table ...in 3T3-L1 adipocytes differentiated in presence or absence of 10, 25 and 50 g/ml of ...
9
Action of nicotinic acid on the reversion of hypoxic-inflammatory link on 3T3-L1 adipocytes
... targets adipocytes through the activa- tion of a G-protein-coupled receptor (GPR-109 A) which is highly expressed in adipose tissue ...in 3T3-L1 adipocytes ...rabbit adipocytes treated ...
8
Involvement of CSE/ H2S in high glucose induced aberrant secretion of adipokines in 3T3-L1 adipocytes
... injury include reducing nitric oxide (NO) bioavailability and increasing reactive oxygen species (ROS) leading to endothelial dysfunction [23]. Recent studies showed that glucose can increase the release of ...
7
A possible regulatory link between Twist 1 and PPARγ gene regulation in 3T3-L1 adipocytes
... The PPARγ antagonist T0070907 has been widely used to inhibit PPARγ activity [23–25]. In this study, we proved that Twist 1 expression of 3T3-L1 adipocytes was downregulated under T0070907, which ...
8
The anti-adipogenic effect of vitexin is via ERK 1/2 MAPK signaling in 3T3-L1 adipocytes
... vitexin, 3T3-L1 adipocytes were cultured in 6 wellplates for 8 days as described in „Materials and ...2C). 3T3-L1 adipocyte treated with vitexin up-regulated ERK 1/2 MAPKs expression, ...
10
Antioxidant, Enzyme Inhibitory and Anti Obesity Potential of Sorrel Calyx Extracts in 3T3 L1 Adipocytes
... Obesity has become one of the greatest threats to global health with studies showing a strong association be- tween obesity and increased risk of developing metabolic disorders such as cardiovascular diseases, hyperten- ...
14
Berberine increases adipose triglyceride lipase in 3T3-L1 adipocytes through the AMPK pathway
... The 3T3-L1 cells, derived from mouse fibroblast cells, could be induced to differentiate to adipocytes, which are widely used in research studies concerning TG me- tabolism and ...differentiated ...
8
Phosphatidylcholine induces apoptosis of 3T3-L1 adipocytes
... in 3T3-L1 pre-adipocytes (Figure ...both 3T3-L1 pre-adipocytes and differentiated 3T3-L1 cells (Figures 3B and ...
7
Flavonoids from Tetracera indica Merr induce adipogenesis and exert glucose uptake activities in 3T3 L1 adipocyte cells
... uptake, 3T3-L1 adipocytes were treated with the maximum non-toxic concentrations of ethanol extract, sub-fractions and isolated compounds to stimulate 2-NBDG in the ab- sence and presence of insulin ...
14
c Cbl–deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action
... in adipocytes independent of the PI3K/Akt pathway (2). In 3T3-L1 adipocytes, c-Cbl forms a complex with 2 adaptor proteins, APS and ...
9
<p>Bioactive fraction from <em>Lagerstroemia speciosa</em> leaves (DLBS3733) reduces fat droplet by inhibiting adipogenesis and lipogenesis</p>
... mouse 3T3-L1 adipocytes, a basic cell model to assess adi- pogenesis and adipocyte metabolism in ...using 3T3-L1 preadipocyte cells and the differentiated 3T3-L1 adipocyte ...
13