4-oxadiazoles
![SYNTHESIS OF 2-(8-BROMONAPHTHO[2,1-B]FURAN-2-YL)-5-ARYL-1,3,4-OXADIAZOLES AS POTENTIAL ANTIMICROBIAL AGENTS](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
SYNTHESIS OF 2-(8-BROMONAPHTHO[2,1-B]FURAN-2-YL)-5-ARYL-1,3,4-OXADIAZOLES AS POTENTIAL ANTIMICROBIAL AGENTS
... 2-carbohydrazides 4(a-f), which underwent smooth cyclization on treatment with phosphorus oxychloride to furnish 2-(8-bromonaphtho[2,1-b]furan-2-yl)-5-aryl-1,3,4-oxadiazoles ...the oxadiazoles 5(a-k) ...
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Synthesis, characterization and biological activities of 2,5-disubstituted 1,3,4–oxadiazoles
... A series of 2,5–disubstituted 1,3,4-oxadiazoles 5a-k have been synthesized by the condensation of p-phenyl sulphonyl benzohydrazide with various aromatic acids in the presence of phosphorous oxy chloride. The ...
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Synthesis, characterization and biological activities of new bis 1,3,4 oxadiazoles
... Several methods are reported in literature for synthesis of 1,3,4-Oxadiazoles [14-17]. However, these methods suffer from disadvantages such as long reaction time, requirement of severe conditions [14, 16] and use ...
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Synthesis, antimicrobial and antiinflammatory activity of 2,5-disubstituted-1,3,4-oxadiazoles
... Nagalakshmi: Synthesis, Antimicrobial and Antiinfl ammatory Activity 2,5-Disubstituted-1,3,4-oxadiazoles In the present study, 2,5-disubstituted-1,3,4-oxadiazoles (3a-o) have been synthesized by the ...
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Computer Added Drug Design of 1,3,4 oxadiazoles as antimycobacterial agents
... The in vitro percentage inhibition values for anti-mycobacterial activities of 5-aryl-2-thio-1, 3, 4-oxadiazoles against M .tuberculosis H37 Rv were taken from the literature [9]. To these values, we have ...
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Synthesis, Antiinflammatory and Antimicrobial Activities of Newer Series of 1,3,4-Oxadiazoles.
... This is to certify that the dissertation entitled “SYNTHESIS, ANTIINFLAMMATORY AND ANTIMICROBIAL ACTIVITIES OF NEWER SERIES OF 1,3,4-OXADIAZOLES” submitted to The Tamil Nadu Dr. M.G.R. Medical University in ...
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Synthesis, Antibacterial and Antioxidant Activity of Novel Bis 1,3,4 oxadiazoles Carrying Pyrazole Moiety
... Meanwhile 1,3,4-oxadiazoles are the heterocyclic compounds containing two nitrogen and one oxygen atom in a five membered ring. Derivatives of 1,3,4-oxadiazoles have exhibited significant pharmacological ...
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SYNTHESIS AND IN VITRO ANTIOXIDANT ACTIVITY OF SOME NEW 2, 5 DISUBSTITUTED 1, 3, 4 OXADIAZOLES CONTAINING FURAN MOIETY
... 3, 4- oxadiazoles constitute a unique class of nitrogen and oxygen containing five membered heterocycles and are reported to possess antifungal 1 , antibacterial 6, 7 , anti-inflammatory 8, 11 , ...
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1,2,4 Oxadiazoles from cycloreversions of oxadiazabicyclo[3 2 0]heptenes: 1 azetines as thiocyanate equivalents
... this transformation proceeded through a [2+2] cycloreversion to give a non-isolable, high-energy azacyclopentadienone 15 and a styrene. The styrene and intermediate 15 then recombine by Diels-Alder reaction, followed by ...
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Synthesis and antimicrobial activity of novel compounds containing pyrazolones and 1,3,4 oxadiazoles
... 1,3,4-Oxadiazoles belong to the group of heterocycles that have been attracting attention for last two decades due to their wide range of biological interactions. Many of them exhibit antibacterial, ...
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Electrocyclization of Semicarbazone; A Novel Route of Green Synthesis of 2,5-Disubstituted-1,3,4-Oxadiazoles
... 1,3,4- oxadiazoles is based on the preparation of acylhydrazones from unprotected acylhydrazines and aldehydes, followed by oxidation with a variety of oxidizing agents ...
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Synthesis, characterization, antimicrobial and antioxidant activity of some disubstituted [1,3,4] oxadiazoles carrying 4 (methylsulfonyl/sulfinyl)benzyl moieties
... [1,3,4]-Oxadiazoles constitute an important family of heterocyclic compounds as they have attracted significant interest in medicinal chemistry, pesticide chemistry and polymer science. Since many of ...
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Synthesis, Characterization and Antimicrobial Evaluation of 1,3,4-Oxadiazoles Clubbed Schiff Base Derivatives
... We have synthesized new 1,3,4-oxadiazoles-clubbed Schiff base derivatives with potent antimicrobial activity from available the starting material methyl 4-chlorobenzoate by routine method. The new compound ...
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Anti inflammatory activity of novel hdac8 inhibitory 2,5 disubstituted 1,3,4 oxadiazoles with glycine/alanine hybrids
... reduces pro-inflammatory cytokine production without affecting the cell viability (Li et al., 2015). We, previosly, synthesized, characterized and determined the HDAC8 selectivity of a series of 10 novel ...
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SYNTHESIS AND EVALUATION OF PHARMACOLOGICAL ACTIVITIES OF SOME 1,3,4 OXADIAZOLES,1,2,4 TRIAZOLES POSSESSING s TRIAZOLE MOIETY
... 4. Maryam Zahid, Khawaja A.Yasin, Tashfeen Akhtar, Nasim H.Rama, Shalid Hameed, Najim A.Al.Masoudi, Roberta Laddo and Paolo La Colla. Synthesis and invitro antiproliferative activity of new ...
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Synthesis and antimicrobial activity of novel Indol compounds containing 2-azitidinones and 1,3,4 oxadiazoles
... 1,3,4,-Oxadiazoles are five membered heterocycles having two nitrogen atoms and one oxygen atom. 1,3,4-oxadiazoles belong to the group of heterocycles that have been attracting attention for last two ...
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Synthesis and antioxidant activity of disubstituted 1,3,4 oxadiazoles, 1,3,4 thiadiazoles and 1,2,4 triazoles
... Some new 2-(arylsulfonylethylsulfonylmethyl)-5-(2-chlorophenyl)-1,3,4-oxadiazoles / thiadiazoles / triazoles (7,9,11) and 2-(benzylsulfonylethylsulfonyl-methyl)-5-(2-chlorophenyl)-1,3,4-oxadiazole / thiadiazoles / ...
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Ionic liquid mediated safer synthetic routes for schiff bases and 1,3,4-oxadiazoles
... Heterocycles are abundant in nature and are of great significance to life because their structural subunits exist in many natural products. Among the heterocyclic compounds 1,3,4-oxadiazoles are non naturally ...
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Synthesis and Preliminary Antibacterial Effects of New 1, 3, 4-Oxadiazoles
... 1,3,4-Oxadiazoles undergo several reactions like photochemical [16], thermal [17], electrophilic [18] and nucleophilic [19] substitution. Synthesis of 1,3,4-oxadiazole containing compounds and investigation of ...
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SOLID SUPPORTED MICROWAVE ASSISTED RAPID SYNTHESIS OF 1, 3, 4 OXADIAZOLES
... Silica gel (3gm) was added to the mixture of hydrazone (0.01mol) and acetic anhydride (2ml) at room temperature. The reaction mixture was thoroughly mixed; the adsorbed material was dried in air and irradiated in ...
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