5-deiodinase (type III)
Iodothyronine 5' deiodinase in rat kidney microsomes Kinetic behavior at low substrate concentrations
... activities, with apparent Michaelis constants (Km) of 0.5 microM and 2.5 nM. Lineweaver- Burk plots of reaction velocities at nanomolar substrate concentrations in presence of 100 microM propylthiouracil also revealed an ...
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Dual mechanisms of regulation of type I iodothyronine 5' deiodinase in the rat kidney, liver, and thyroid gland Implications for the treatment of hyperthyroidism with radiographic contrast agents
... Alterations in thyroid hormone status and the administration of radiographic contrast agents can markedly influence iodothyronine metabolism and, in particular, the activity of type I 5'- deiodinase ...
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Somatostatin inhibits rat hepatic T4 5' deiodinase The effect is independent of the associated hypoinsulinemia
... +/- 5 pmol/min per 100 mg protein) and 72 h (90 +/- 7 pmol/min per 100 mg protein) was significantly reduced in the high-dose group (P less than ...T4-5'- deiodinase activity in the glucose-fed ...
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Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5' deiodinase deficiency
... the type I iodothyronine 5'deiodinase (5'DI), one of two enzymes that metabolize thyroxine (T4) to 3,5,3'-triiodothyronine ...renal 5'DI mRNA in a high (C57BL/6J) and low (C3H/HeJ) ...
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Ontogenesis of iodothyronine 5' deiodinase Induction of 5' deiodinating activity by insulin, glucocorticoid, and thyroxine in cultured fetal mouse liver
... iodothyronine-5'- deiodinase in the fetal and neonatal period, fetal mouse liver of the 19th day of gestation, in which no iodothyronine-5'-deiodinating activity was detectable, was cultured in ...
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Potential of brown adipose tissue type II thyroxine 5' deiodinase as a local and systemic source of triiodothyronine in rats
... (BAT) type II 5'-deiodinase to generate T3 for the plasma ...BAT 5'-deiodination (BAT 5'D) was stimulated by either short- (4 h) or long-term (7 wk) cold exposure (4 degrees ...
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Type II 5’Deiodinase Thr92Ala Polymorphism Is Associated with CVD Risk among Type 2 Diabetes Mellitus Patients
... In conclusion, to the best of our knowledge, this is the first study intended to understand the association of DIO2 Thr92Ala SNP on thyroid function and the development of CVD risk among the South Indian type 2 ...
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Rapid alteration in circulating free thyroxine modulates pituitary type II 5' deiodinase and basal thyrotropin secretion in the rat
... thyrotroph would have a mechanism for modulating the production of T3, if T3 is, in fact, the sole bioactive signal providing negative feedback inhibition. To examine this apparent paradox, we administered EMD 21388, a ...
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Thyroid hormone deiiodinases
... Using these assays, 5'-deiodinase enzyme activities have been localized to the plasma membranes, to the endoplasmic reticulum and to the lysosomes prepared from liver and kidney homogena[r] ...
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Interrelationships among thyroxine, growth hormone, and the sympathetic nervous system in the regulation of 5' iodothyronine deiodinase in rat brown adipose tissue
... BAT 5'D but by a mechanism mediated through a long-lived messenger that correlates with growth ...BAT 5'D to increase abruptly after thyroidectomy as does the type II 5'-deiodinase in ...
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Qualitative and quantitative differences in the pathways of extrathyroidal triiodothyronine generation between euthyroid and hypothyroid rats
... iodothyronine 5'- deiodinase activity (5'D-I), reduces extrathyroidal T4 to T3 conversion by only 60-70% in euthyroid ...tissue. 5'D-II is insensitive to PTU ...
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Metabolic effect of 3,3',5' triiodothyronine in cultured growth hormone producing rat pituitary tumor cells Evidence for a unique mechanism of thyroid hormone action
... Physiologic levels of 3,3',5'-triiodothyronine (rT3) are generally believed to have minimal metabolic effects in the pituitary gland and other tissues. In the present studies, the regulatory role of rT3 and other ...
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The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue
... Most homeotherms maintain body temperature by increasing heat production in response to cold. This process, adaptive thermogenesis, is achieved by shivering or by uncoupling oxidative phosphorylation in brown adipose ...
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Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans
... incubations, deiodinase activities can be quantitated in the same cells under conditions used to assay deiodinase activity in human tissues (Figure ...
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Pregnant rat uterus expresses high levels of the type 3 iodothyronine deiodinase
... Although thyroid hormones are critically important for the coordination of morphogenic processes in the fetus and neonate, premature exposure of the embryo to levels of the hormones present in the adult is detrimental ...
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Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes
... supraphysiologic quantities of T3 can also act by the same mechanism in addition to suppressing D2 mRNA synthesis (5, 6, 11, 26, 28). rT3 causes the expected rapid decrease in D2 ac- tivity in GH4C1 cells with an ...
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Clinical, behavioural and pharmacogenomic factors influencing the response to levothyroxine therapy in patients with primary hypothyroidism—protocol for a systematic review
... Three percent of the UK population receive thyroid hor- mone replacement therapy [4]. Synthetic levothyroxine is commonly used, and the goal of therapy is to achieve clin- ical wellbeing and restore serum TSH levels to ...
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Maturational Patterns of Iodothyronine Phenolic and Tyrosyl Ring Deiodinase Activities in Rat Cerebrum, Cerebellum, and Hypothalamus
... Nonradioactive T 4 , T 3 , and 3,3¢,5¢-triiodothyronine (rT 3 ) were included, as appropriate. The net production rate of [ 125 I]T 3 from T 4 in 1-d cerebral homogenates was similar to the rate in adult cerebral ...
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The overexpression of MDM4: an effective and novel predictor of gastric adenocarcinoma lymph node metastasis
... Total protein was isolated from 30 pairs of fresh GTAC and adjacent normal gastric tissues. An equal amount of protein from the tissues was separated through sodium dodecyl sulfate-polyacrylamide gel electrophoresis and ...
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The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration
... The deiodinase family of enzymes controls the tissue-specific activation and inactivation of the prohormone thyroxine ...that type 2 deiodinase (D2) is essential for normal mouse myogenesis and ...
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