5-PHENYL-3-(PYRIDIN-2-YL)-1H-1

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Ethyl 2 {[5 (3 chloro­phen­yl) 1 phenyl 1H pyrazol 3 yl]­­oxy}acetate

Ethyl 2 {[5 (3 chloro­phen­yl) 1 phenyl 1H pyrazol 3 yl]­­oxy}acetate

Since the discovery of the strobilurin fungicide pyraclostrobin by BASF scientists, 1 H -pyrazol-3-oxy derivatives have attracted considerable attention in chemical and medicinal research because of their low mammalian toxicity and diverse bioactivities (Li et al. , 2010). Furthermore, several biological studies have also pointed out the value of alkyloxyacetates (Tohyama & Sanemitsu, 2001) as bioactive groups. Recently, focusing on incorporating an alkyloxyacetate group into 1 H -pyrazol-3-oxy derivatives in the hope of obtaining compounds with potential bioactivities, we report here the crystal structure of the title compound (I).

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Di­aqua­bis­­{5 (pyridin 2 yl κN) 3 [4 (pyri­din 4 yl)phenyl] 1H 1,2,4 triazol 1 ido κN1}zinc

Di­aqua­bis­­{5 (pyridin 2 yl κN) 3 [4 (pyri­din 4 yl)phenyl] 1H 1,2,4 triazol 1 ido κN1}zinc

The title compound, Fig. 1, possesses inversion symmetry, and consists of a zinc atom (located on the inversion center) coordinated to two symmetry related deprotonated 2-(3-(4-(pyridin-4- yl)phenyl)-1H-1,2,4-triazol-5-yl)pyridine ligands and two water molecules. The zinc atom, Zn1, has a distorted ZnN4O2 octahedral coordination geometry; completed by four N atoms of the ligand and two O atoms from the two water molecules. The Zn1—O1 distance is 2.301 (4) Å, and the Zn—N distances varying from 2.048 (3) - 2.134 (3) Å.

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Crystal structure of pirfenidone (5 methyl 1 phenyl 1H pyridin 2 one): an active pharmaceutical ingredient (API)

Crystal structure of pirfenidone (5 methyl 1 phenyl 1H pyridin 2 one): an active pharmaceutical ingredient (API)

A search of the Cambridge Structural Database (CSD, Version 5.40, February 2019; Groom et al., 2016) for 1-phenylpyridin-2(1H)-ones, excluding structures with ring atoms being included in further cyclic moieties, gave 40 hits (see supporting information file S1). Only six of these compounds involve an unsubstituted phenyl ring as in the title compound. When considering compounds with no substituent in position-6 of the pyridinone ring (on atom C5 in the title compound; Fig. 1) only three structures fit this extra criteria, viz. S-ethyl 2-oxo-1-phenyl-1,2-dihydro-3-pyridinecarbothio- ate (CSD refcode NOLBIA; Liu et al., 2008), monoclinic space group P2 1 , 4-chloro-6-oxo-1-phenyl-1,6-dihydropyridine-3-

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Crystal structure of (2 hy­dr­oxy 5 methyl­phen­yl)(3 methyl 1 phenyl 1H pyrazolo­[3,4 b]pyridin 5 yl)methanone

Crystal structure of (2 hy­dr­oxy 5 methyl­phen­yl)(3 methyl 1 phenyl 1H pyrazolo­[3,4 b]pyridin 5 yl)methanone

Data collection: APEX2 (Bruker, 2008); cell refinement: SAINT (Bruker, 2008); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 for Windows (Farrugia, 2012); software used to prepare material for publication: SHELXL97 and PLATON (Spek, 2009).

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Crystal structure of [4 (2 meth­­oxy­phen­yl) 3 methyl 1 phenyl 6 tri­fluoro­methyl 1H pyrazolo­[3,4 b]pyridin 5 yl](thio­phen 2 yl)methanone

Crystal structure of [4 (2 meth­­oxy­phen­yl) 3 methyl 1 phenyl 6 tri­fluoro­methyl 1H pyrazolo­[3,4 b]pyridin 5 yl](thio­phen 2 yl)methanone

Many polysubstituted derivatives of 1H-pyrazolo[3,4-b]pyridine have been synthesized as potentially biologically active materials (Hardy, 1984; Chu & Lynch, 1975) and established as antimicrobial agents against bacterial and fungal strain (Ali, 2009). Thiophenes are regarded as important building units for a variety of drugs. Recently, a new class of thiophene compounds that kill extensively drug resistant Mycobacterium tuberculosis have been reported (Wilson et al., 2013). An evaluation of the cytotoxic activities of some thiophene derivatives have indicated that they could be considered promising compounds for the discovery of new antitumor agents (Souza et al., 2012). Also, in the background of coumarin dyes being successfully used as organic dye photo-sensitizers for Dye-Sensitized-Solar-Cells (DSSC), the design of new coumarin dyes through the introduction of thiophene moieties have shown to remarkably improve the solar cell performance (Hara et al., 2003).

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1 [1 (4 Fluoro­phen­yl) 2 methyl 5 phenyl 1H pyrrol 3 yl]ethanone

1 [1 (4 Fluoro­phen­yl) 2 methyl 5 phenyl 1H pyrrol 3 yl]ethanone

Data collection: SMART (Bruker, 2000); cell refinement: SAINT (Bruker, 2000); data reduction: SAINT; program(s) used to solve structure: SIR92 (Altomare et al., 1993); program(s) used to refine structure: SHELXL97 (Sheldrick, 1997); molecular graphics: ORTEP-3 for Windows (Farrugia, 1997) and CAMERON (Watkin et al., 1993); software used to prepare material for publication: PLATON (Spek, 2003).

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2 [5 (4 Hy­droxy­phen­yl) 1 phenyl 1H pyrazol 3 yl]phenol

2 [5 (4 Hy­droxy­phen­yl) 1 phenyl 1H pyrazol 3 yl]phenol

Pyrazoles are important because of their potential for biological activity (Beeam et al., 1984). Both traditional and new scientific methods have been used used to prepare new materials for medicine (Elguero et al., 1983) and agriculture (Trofinenko, 1972). Neutral and anionic pyrazoles are excellent ligands and their co-ordination chemistry has been extensively studied (Bonati, 1980). In the molecular structure of the title compound (III) (Fig. 1 and Fig. 3) there is an intramolecular hydrogen bond between the OH group of one phenolic group and the N atom of the pyrazole group (see Table 1 for hydrogen bond details). One of the phenyl groups is approximately coplanar with the pyrazole groups (dihedral angle = 7.5 (3)°), possibly due to the intramolecular hydrogen bond formation. The other two phenyl groups are rotated by 66.4 (12)°. In the crystal structure an intermolecular hydrogen bond between non equivalent hydroxy groups of symmetry related molecules, forms extended chains along [201] (Fig. 2).

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2 [3 (4 Methoxyphen­yl) 1 phenyl 1H pyrazol 5 yl]phenol

2 [3 (4 Methoxyphen­yl) 1 phenyl 1H pyrazol 5 yl]phenol

Pyrazoles are important because of their potential for biological activity. They have antipruritic, anti-inflammatory and antirheumatic effects (Beeam et al., 1984). Both traditional and new scientific methods have been used to prepare new materials for medicine (Elguero et al., 1983) and agriculture (Trofinenko, 1972). Neutral and anionic pyrazoles are excellent ligands and their coordination chemistry has been extensively studied (Bonati, 1980). Pyrazoles are also used as analytical reagents (Freyer & Radeglia, 1981). In the molecular structure of the title compound, C 22 H 18 N 2 O 2 , (Scheme 1,

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Ethyl 2 [1 (3 methyl­but­yl) 4 phenyl 1H 1,2,3 triazol 5 yl] 2 oxo­acetate

Ethyl 2 [1 (3 methyl­but­yl) 4 phenyl 1H 1,2,3 triazol 5 yl] 2 oxo­acetate

C7 0.0368 (6) 0.0365 (6) 0.0363 (6) 0.0101 (5) 0.0038 (5) 0.0005 (5) C8 0.0380 (6) 0.0366 (7) 0.0383 (6) 0.0128 (5) 0.0035 (5) 0.0053 (5) C9 0.0485 (7) 0.0357 (7) 0.0451 (7) 0.0111 (6) 0.0019 (6) 0.0003 (5) C10 0.0434 (7) 0.0426 (7) 0.0450 (8) 0.0072 (6) −0.0027 (6) −0.0046 (6) C11 0.0444 (8) 0.0788 (12) 0.0589 (10) 0.0218 (8) −0.0053 (7) 0.0015 (8) C12 0.0546 (10) 0.0810 (13) 0.0877 (14) 0.0252 (9) 0.0058 (10) −0.0090 (11) C13 0.0537 (8) 0.0490 (8) 0.0548 (9) 0.0249 (7) 0.0094 (7) 0.0193 (7) C14 0.0534 (9) 0.0615 (10) 0.0717 (11) 0.0276 (8) 0.0182 (8) 0.0240 (8) C15 0.0625 (10) 0.0658 (11) 0.0666 (11) 0.0318 (9) 0.0047 (8) 0.0055 (8) C16 0.137 (2) 0.129 (2) 0.0923 (18) 0.086 (2) 0.0459 (17) 0.0216 (16) C17 0.0965 (15) 0.0644 (12) 0.0859 (14) 0.0416 (11) 0.0122 (12) 0.0181 (10)

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4 Phenyl 3 (pyridin 4 yl) 1H 1,2,4 triazole 5(4H) thione

4 Phenyl 3 (pyridin 4 yl) 1H 1,2,4 triazole 5(4H) thione

Among the pharmacological profiles of 1,2,4-triazoles, their antimicrobial, anticonvulsant and antidepressant properties seem to be the best documented. Derivatives of 4,5-disub- stituted 1,2,4-triazole are known, synthesized by intramol- ecular cyclization of 1,4-disubstituted thiosemicarbazides (Zamani et al., 2003; Cansız et al., 2004). In addition, there are some studies on the electronic structures and thiol–thione tautomeric equilibria of heterocyclic thione derivatives (Aydog˘an et al., 2002; Charistos et al., 1994). We present here the structure of a new 1,2,4-triazole derivative, namely 4- phenyl-3-(pyridin-4-yl)-1H-1,2,4-triazole-5(4H)-thione, (3) (Fig. 1).

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Tris(5 methyl 3 phenyl 1H pyrazol 1 yl)methane

Tris(5 methyl 3 phenyl 1H pyrazol 1 yl)methane

are 29 (3)°, 23 (2)° and 62 (1)° (Declercq & Van Meerssche, 1984)] and triphenylmethane [30°, 34° and 53°, and 21°, 38° and 47° for each one of the two molecules in the asymmetric unit (Riche & Pascard-Billy, 1974)]. A further method for describing this helical twist is through H1A–C1–N–N torsion angles (Ochando et al., 1997). The torsion angles for I are 133.7 (3)°, -18.3 (4)° and 148.9 (3)° for H1A–C1–N1–N2, H1A–C1–N3–N4 and H1A–C1–N5–N6, respectively. These are in good agreement with the values observed in tpzm Me,Me [121 (1)°, -21 (1)° and 147 (1)° (Declercq & Van Meerssche,

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3 Eth­oxy­carbonyl 1 phenyl 1H pyrazol 5 yl 4 chloro­benzoate

3 Eth­oxy­carbonyl 1 phenyl 1H pyrazol 5 yl 4 chloro­benzoate

C9 0.054 (2) 0.086 (3) 0.079 (2) −0.0139 (18) 0.0201 (18) −0.014 (2) C10 0.0480 (17) 0.072 (2) 0.0618 (18) −0.0081 (16) 0.0136 (15) −0.0041 (16) C11 0.0438 (16) 0.077 (2) 0.071 (2) −0.0016 (15) 0.0102 (15) −0.0012 (17) C12 0.0404 (16) 0.0666 (19) 0.0581 (18) −0.0077 (14) −0.0014 (13) 0.0026 (15) C13 0.0458 (16) 0.065 (2) 0.0571 (18) 0.0022 (15) 0.0084 (14) 0.0043 (16) C14 0.0422 (15) 0.0604 (18) 0.0528 (17) −0.0012 (14) 0.0093 (13) −0.0025 (14) C15 0.0592 (18) 0.0616 (19) 0.0575 (17) −0.0029 (15) 0.0038 (14) 0.0026 (15) C16 0.071 (2) 0.071 (2) 0.075 (2) −0.0122 (17) 0.0044 (18) −0.0052 (17) C17 0.0556 (18) 0.085 (2) 0.070 (2) −0.0073 (17) 0.0033 (16) −0.0161 (19) C18 0.067 (2) 0.090 (2) 0.0557 (18) 0.0051 (18) −0.0072 (16) −0.0045 (18) C19 0.0612 (18) 0.073 (2) 0.0584 (19) −0.0038 (16) 0.0061 (15) 0.0047 (16)

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Di­aqua­bis­­{3 [4 (1H imidazol 1 yl)phenyl] 5 (pyridin 2 yl κN) 1H 1,2,4 triazol 1 ido κN1}zinc

Di­aqua­bis­­{3 [4 (1H imidazol 1 yl)phenyl] 5 (pyridin 2 yl κN) 1H 1,2,4 triazol 1 ido κN1}zinc

ion located on a center of symmetry, two 3-[4-(1H-imidazol-1-yl)phenyl]-5- (pyridin-2-yl)-1H-1,2,4-triazol-1-ide (Ippyt) ligands and two coordinating water molecules. The Zn II ion is six-coordinated in a distorted octahedral coordination geometry by four N atoms from two Ippyt ligands and by two O atoms from two water molecules. Adjacent units are interconnected though O—H N hydrogen bonds, forming a three-dimensional network.

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3 Methyl 1 phenyl 1H pyrazol 5 yl 2,4 di­chloro­benzoate

3 Methyl 1 phenyl 1H pyrazol 5 yl 2,4 di­chloro­benzoate

C8 0.054 (2) 0.062 (2) 0.066 (2) 0.0130 (17) −0.0017 (18) −0.0075 (18) C9 0.053 (2) 0.061 (2) 0.065 (2) 0.0075 (17) 0.0068 (17) 0.0033 (17) C10 0.0494 (18) 0.0469 (19) 0.0505 (18) 0.0063 (15) −0.0021 (14) 0.0010 (15) C11 0.058 (2) 0.067 (2) 0.057 (2) 0.0100 (18) 0.0079 (17) 0.0176 (18) C12 0.0460 (17) 0.0428 (18) 0.059 (2) −0.0013 (14) −0.0071 (15) 0.0020 (15) C13 0.0552 (19) 0.053 (2) 0.060 (2) −0.0023 (16) −0.0103 (16) 0.0082 (16) C14 0.072 (2) 0.060 (2) 0.065 (2) 0.0095 (19) −0.0226 (19) 0.0025 (18) C15 0.070 (2) 0.055 (2) 0.076 (3) 0.0148 (18) −0.027 (2) −0.0166 (19) C16 0.070 (2) 0.066 (2) 0.064 (2) 0.0132 (19) −0.0097 (18) −0.0158 (18) C17 0.058 (2) 0.0495 (19) 0.055 (2) 0.0036 (15) −0.0055 (16) −0.0031 (15)

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N,N Di­ethyl 4 [1 phenyl 3 (pyridin 2 yl) 4,5 di­hydro 1H pyrazol 5 yl]aniline

N,N Di­ethyl 4 [1 phenyl 3 (pyridin 2 yl) 4,5 di­hydro 1H pyrazol 5 yl]aniline

C1 0.0467 (15) 0.0507 (15) 0.0640 (17) 0.0005 (12) 0.0025 (13) −0.0102 (13) C2 0.0719 (19) 0.0515 (16) 0.0733 (18) −0.0062 (14) −0.0061 (15) −0.0017 (14) C3 0.093 (2) 0.0560 (18) 0.093 (2) −0.0094 (17) −0.0055 (19) 0.0011 (16) C4 0.091 (2) 0.060 (2) 0.107 (2) −0.0093 (18) 0.000 (2) −0.0174 (17) C5 0.085 (2) 0.070 (2) 0.091 (2) −0.0079 (19) 0.0039 (19) −0.0321 (18) C6 0.0451 (14) 0.0499 (15) 0.0558 (16) 0.0017 (12) 0.0025 (12) −0.0043 (12) C7 0.0558 (16) 0.0582 (16) 0.0542 (16) 0.0055 (13) 0.0029 (13) −0.0026 (13) C8 0.0491 (15) 0.0538 (16) 0.0528 (16) −0.0022 (12) 0.0035 (12) 0.0057 (13) C9 0.0431 (14) 0.0415 (14) 0.0601 (15) 0.0028 (11) −0.0010 (12) −0.0026 (12) C10 0.0593 (17) 0.0488 (16) 0.0701 (17) −0.0025 (13) 0.0002 (14) 0.0051 (13) C11 0.0580 (17) 0.0444 (15) 0.0845 (19) −0.0060 (13) 0.0023 (15) −0.0043 (14) C12 0.0580 (17) 0.0526 (16) 0.0785 (18) 0.0024 (13) 0.0012 (15) −0.0182 (15) C13 0.0638 (17) 0.0558 (16) 0.0628 (17) 0.0054 (14) 0.0012 (14) −0.0082 (14) C14 0.0549 (15) 0.0440 (15) 0.0595 (16) 0.0041 (12) 0.0027 (13) −0.0022 (12) C15 0.0514 (14) 0.0491 (15) 0.0505 (14) −0.0032 (12) 0.0020 (11) 0.0032 (12) C16 0.0616 (16) 0.0541 (16) 0.0554 (16) −0.0025 (13) 0.0011 (13) 0.0052 (13) C17 0.0693 (18) 0.0611 (18) 0.0687 (18) 0.0042 (15) −0.0066 (14) 0.0106 (15) C18 0.0663 (17) 0.0719 (19) 0.089 (2) 0.0109 (15) 0.0018 (15) 0.0032 (17) C19 0.0621 (17) 0.0722 (19) 0.0636 (17) 0.0075 (15) 0.0114 (14) 0.0130 (15) C20 0.0684 (19) 0.085 (2) 0.0787 (19) 0.0111 (16) 0.0192 (16) 0.0080 (17) C21 0.106 (3) 0.121 (3) 0.123 (3) 0.024 (3) 0.004 (2) 0.006 (3) C22 0.164 (4) 0.140 (4) 0.150 (4) 0.008 (3) 0.005 (3) 0.021 (3) C23 0.090 (3) 0.113 (3) 0.119 (3) 0.024 (2) 0.009 (2) −0.002 (3) C24 0.114 (4) 0.133 (4) 0.134 (4) 0.001 (3) 0.012 (3) 0.001 (3) C21′ 0.112 (3) 0.119 (3) 0.123 (3) 0.022 (3) 0.003 (3) 0.013 (3) C22′ 0.153 (5) 0.135 (4) 0.149 (5) 0.003 (4) 0.008 (4) 0.005 (3) C23′ 0.094 (3) 0.114 (3) 0.116 (3) 0.019 (3) 0.013 (3) −0.001 (3) C24′ 0.123 (4) 0.130 (4) 0.130 (5) 0.000 (3) 0.013 (4) −0.002 (4) N1 0.0858 (18) 0.116 (2) 0.121 (2) 0.0296 (16) 0.0086 (16) 0.0113 (17) N2 0.0629 (16) 0.0440 (14) 0.0571 (15) −0.0043 (11) −0.0099 (12) 0.0060 (11) N3 0.0510 (14) 0.0407 (14) 0.0578 (15) −0.0016 (11) −0.0027 (11) 0.0016 (11) N4 0.0717 (19) 0.0666 (19) 0.0706 (19) −0.0078 (14) 0.0057 (14) −0.0201 (15)

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Crystal structure of chlorido­{1 (2,3 di­methyl 5 oxido 1 phenyl 1H pyrazol 2 ium 4 yl κO) 2 [3 methyl 5 oxo 1 phenyl 4,5 di­hydro 1H pyrazol 4 yl­­idene κO]hydrazin 1 ido κN1}copper(II) from laboratory X ray powder data

Crystal structure of chlorido­{1 (2,3 di­methyl 5 oxido 1 phenyl 1H pyrazol 2 ium 4 yl κO) 2 [3 methyl 5 oxo 1 phenyl 4,5 di­hydro 1H pyrazol 4 yl­­idene κO]hydrazin 1 ido κN1}copper(II) from laboratory X ray powder data

gradient approximation (GGA) and PBE exchange correla- tion function (Perdew et al. , 1996). In simulated annealing runs (without H atoms), the total number of varied degrees of freedom (DOF) was eight: three translational, three orienta- tional and two torsional ones for the rotation of the two phenyl rings. The solution was fitted with the program MRIA (Zlokazov & Chernyshev, 1992) in a bond-restrained Rietveld refinement using a split-type pseudo-Voigt peak-profile func- tion (Toraya, 1986) and symmetrized harmonics expansion up to the 4th order (Ahtee et al., 1989; Ja¨rvinen, 1993) for the texture formalism. Restraints were applied to the intra- molecular bond lengths and contacts (< 2.8 A ˚ ) where the strength of the restraints was a function of interatomic separation and, for intramolecular bond lengths, corresponded to an r.m.s. deviation of 0.02 A ˚ . Additional restraints were applied to the planarity of aromatic rings with the attached atoms, with a maximum allowed deviation from the mean plane of 0.03 A ˚ . All non-H atoms were refined isotropically. H atoms were positioned geometrically (C—H = 0.93–0.96 A ˚ ) and not refined. The experimental and calculated diffraction profile after the final bond-restrained Rietveld refinements is shown in Fig. 3. Crystal data, data collection and structure refinement details are summarized in Table 1.

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Crystal structure of 3 (morpholin 4 yl) 1 phenyl 3 (pyridin 2 yl)propan 1 one

Crystal structure of 3 (morpholin 4 yl) 1 phenyl 3 (pyridin 2 yl)propan 1 one

To an ethanolic solution of acetophenone (3.0 ml, 0.025 mol) taken in a round bottom flask, morpholine (2.1 ml, 0.025 mol) and pyridine-2-carboldehyde (2.6 ml, 0.025 mol) were added. The reaction mixture was kept over a magnetic stirrer and stirred well in an ice cold condition for 3 hr. The colourless solid formed was filtered and washed several times with petroleum ether (40–60%). The crude solid obtained was dried and recrystallized using absolute alcohol. The

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[(1R*,2S*) N1 Benzyl 2 phenyl 1 (pyridin 2 yl) N2 (pyridin 2 ylmeth­yl)ethane 1,2 di­amine]­di­chloridozinc(II)

[(1R*,2S*) N1 Benzyl 2 phenyl 1 (pyridin 2 yl) N2 (pyridin 2 ylmeth­yl)ethane 1,2 di­amine]­di­chloridozinc(II)

C2 0.049 (3) 0.042 (3) 0.038 (3) 0.001 (3) 0.017 (3) 0.004 (2) C3 0.039 (3) 0.034 (3) 0.043 (3) −0.003 (2) 0.019 (2) 0.000 (2) N4 0.037 (2) 0.050 (3) 0.038 (2) 0.001 (2) 0.0144 (19) −0.002 (2) C10 0.046 (3) 0.071 (4) 0.047 (3) −0.001 (3) 0.023 (3) −0.003 (3) C11 0.048 (4) 0.061 (4) 0.072 (4) 0.008 (3) 0.029 (3) 0.006 (4) C12 0.068 (5) 0.074 (5) 0.073 (5) 0.018 (4) 0.017 (4) 0.006 (4) C13 0.091 (7) 0.120 (9) 0.097 (7) 0.040 (6) 0.014 (5) 0.010 (6) C14 0.107 (8) 0.129 (10) 0.133 (10) 0.062 (7) 0.028 (7) 0.021 (8) C15 0.131 (10) 0.107 (9) 0.165 (12) 0.057 (8) 0.062 (9) −0.009 (8) C16 0.091 (6) 0.099 (7) 0.105 (7) 0.026 (5) 0.040 (5) −0.012 (6) C21 0.049 (3) 0.048 (4) 0.039 (3) 0.003 (3) 0.020 (3) 0.008 (3) N22 0.121 (5) 0.050 (4) 0.055 (3) 0.002 (3) 0.047 (4) −0.001 (3) C23 0.162 (9) 0.037 (4) 0.087 (6) 0.003 (5) 0.068 (6) −0.005 (4) C24 0.135 (7) 0.067 (5) 0.070 (5) 0.004 (5) 0.057 (5) −0.026 (4) C25 0.137 (7) 0.083 (6) 0.056 (4) −0.012 (5) 0.059 (5) −0.007 (4) C26 0.106 (6) 0.055 (4) 0.048 (4) −0.002 (4) 0.037 (4) 0.000 (3) C31 0.043 (3) 0.048 (4) 0.048 (3) 0.000 (3) 0.015 (3) −0.014 (3) C32 0.063 (5) 0.092 (6) 0.078 (5) −0.020 (4) 0.013 (4) −0.011 (4) C33 0.069 (6) 0.134 (9) 0.092 (7) −0.028 (6) 0.008 (5) −0.036 (7) C34 0.067 (6) 0.133 (9) 0.063 (5) 0.011 (6) −0.002 (4) −0.032 (6) C35 0.076 (5) 0.108 (7) 0.050 (4) 0.023 (5) 0.004 (4) −0.017 (4) C36 0.054 (4) 0.067 (4) 0.048 (3) 0.011 (3) 0.006 (3) −0.008 (4) C40 0.037 (3) 0.065 (4) 0.053 (3) 0.000 (3) 0.017 (3) −0.006 (3) C41 0.042 (3) 0.054 (4) 0.042 (3) 0.002 (3) 0.017 (3) −0.004 (3) N42 0.039 (3) 0.056 (3) 0.043 (3) 0.000 (2) 0.015 (2) −0.006 (2) C43 0.055 (4) 0.065 (4) 0.047 (3) −0.007 (3) 0.015 (3) −0.006 (3) C44 0.082 (5) 0.073 (5) 0.055 (4) 0.002 (4) 0.030 (4) −0.013 (4) C45 0.067 (5) 0.088 (6) 0.063 (4) 0.014 (4) 0.031 (4) −0.010 (4) C46 0.043 (3) 0.081 (5) 0.056 (4) 0.007 (3) 0.022 (3) −0.006 (4)

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Solid support synthesis of thiazolo pyrazoline derivatives and evaluation of their antimicrobial activities

Solid support synthesis of thiazolo pyrazoline derivatives and evaluation of their antimicrobial activities

A mixture of 3a (0.004mol), ethylcyanoacetate (0.004mol) and 3-4 drops of glacial acetic acid were grinded with pre-conditioned silica- gel using pestle and mortar. The reaction mixture was subjected to microwave pulse at 320W, for 15 minutes. The reaction mixture was kept overnight. The product was extracted with the help of alcohol. The reaction was followed by Thin Layer Chromatography and the conditions were standardized. The crude product was filtered, washed with alcohol and recrystallised from mixture of methanol and benzene as light brown solid. M.P.-213-215 0 C, Expt. Yield-60%.

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Ethyl 2 phenyl 3 (pyridin 2 yl)­acryl­ate

Ethyl 2 phenyl 3 (pyridin 2 yl)­acryl­ate

The title compound was prepared by the photo-induced oxygenation reaction of 2-phenyl-3-(4-chlorobenzoyl)indolizine in ethanol with methylene blue as a sensitizer, and was isolated by column chromatography on silica gel with petroleum ether–ethyl acetate as eluents. Single crystals suitable for the X-ray diffration were obtained from slow evaporation of a petroleum ether-ethyl acetate solution.

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