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5α-Reductase inhibitors

5α-reductase Inhibitors and Risk of High-grade or Lethal Prostate Cancer

5α-reductase Inhibitors and Risk of High-grade or Lethal Prostate Cancer

... 2 -reductase inhibitors (5ARI) have been suggested as chemopreventive agents for prostate ...5-α reductase, facilitates conversion of testosterone to the biologically active form, ...

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Computational comparative QSAR analysis of 5α reductase inhibitors of type 1

Computational comparative QSAR analysis of 5α reductase inhibitors of type 1

... In the present study we have taken structures of -Reductase Inhibitors of humans Type-1 derivatives of 4-Aza-3- oxo--androst-1-ene-17 β-N(X-aryl)-carboxamide from literature. [32] and then ...

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Impact of preoperative 5α-reductase inhibitors on perioperative blood loss in patients with benign prostatic hyperplasia: a meta-analysis of randomized controlled trials

Impact of preoperative 5α-reductase inhibitors on perioperative blood loss in patients with benign prostatic hyperplasia: a meta-analysis of randomized controlled trials

... The present meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement [25].No protocol exists for this meta-analysis. We searched studies from the ...

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Crystal Structure and Synthesis of 3β (p Iodobenzoyloxy) 16α,17α Epoxypregn 4 En 6,20 Dione

Crystal Structure and Synthesis of 3β (p Iodobenzoyloxy) 16α,17α Epoxypregn 4 En 6,20 Dione

... of -reductase inhibitors is the 4-azasteroids, which include the drug fi- nasteride ...first -reductase inhibitor approved in the USA for the treatment of ...2 ...

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A STUDY ON DIHYDROFOLATE REDUCTASE AND ITS INHIBITORS: A REVIEW

A STUDY ON DIHYDROFOLATE REDUCTASE AND ITS INHIBITORS: A REVIEW

... Dihydrofolate reductase (DHFR) was discovered in the late 1950s by investigators searching for folate-dependent enzymes involved in 1-carbon metabolism, with its already known application as anti-cancer and as ...

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Oxidative stress in prostate hyperplasia and carcinogenesis

Oxidative stress in prostate hyperplasia and carcinogenesis

... -Reductase inhibitors; 5-ARIs, 5 α -reductase inhibitors; 8-EPI, 8-isoprostanes; 8-OHdG, 8-hydroxy-2'-deoxyguanosine; ADT, Androgen deprivation therapy; Akt, Alpha serine/threonine-protein ...

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The clinical significance of statins-macrolides interaction: comprehensive review of in vivo studies, case reports, and population studies

<p>The clinical significance of statins-macrolides interaction: comprehensive review of in vivo studies, case reports, and population studies</p>

... The increased exposure of simvastatin, lovastatin, and atorvastatin when coadministered with clarithromycin, tel- ithromycin, and erythromycin is evident, but the signi fi - cance of this increased exposure to the ...

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Pleiotropic effects of the HMG-CoA reductase inhibitors

Pleiotropic effects of the HMG-CoA reductase inhibitors

... The pleiotropic effects of statins are attributed to several processes resulting from the inhibition of HMG-CoA reductase. The main effect of statins is the inhibition of cholesterol and isoprenoid synthesis, ...

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5α-reductase activity in women with polycystic ovary syndrome: a systematic review and meta-analysis

5α-reductase activity in women with polycystic ovary syndrome: a systematic review and meta-analysis

... studies, - reductase was positively correlated with body weight in adult women with PCOS [14, ...affect -reductase activity in patients with ...

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Expression of 5α- and 5β-reductase in spinal cord and muscle of birds with different courtship repertoires

Expression of 5α- and 5β-reductase in spinal cord and muscle of birds with different courtship repertoires

... 1 -reductase in zebra finches may be functionally opposed by the increased expression of 5β-reductase, which may inactivate T locally reducing its availability for conversion to -DHT ...

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Benzopyrazines: Synthesis, Characterization and Evaluation as Aldose Reductase Inhibitors

Benzopyrazines: Synthesis, Characterization and Evaluation as Aldose Reductase Inhibitors

... Aldehyde reductase (ALR1) isolation and purification; from local slaughter house calf kidneys were obtained which were then dissolved in 3 volumes of 10 mM sodium phosphate buffer having pH ...

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Modulatory Effect of α-tocopherol in Simvastatin and Gemfibrozil Induced Rhabdomyolysis in Rats

Modulatory Effect of α-tocopherol in Simvastatin and Gemfibrozil Induced Rhabdomyolysis in Rats

... with myopathy and rhabdomyolysis. In the present study administration of simvastatin + gemfibrozil produced rhabdomyolysis in rats characterized by increase in CPK, LDH, SGOT, CRTN, UREA and BUN. They also caused ...

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A49T, V89L and TA repeat polymorphisms of steroid 5α reductase type II and breast cancer risk in Japanese women

A49T, V89L and TA repeat polymorphisms of steroid 5α reductase type II and breast cancer risk in Japanese women

... Steroid -reductase converts testosterone to the meta- bolically more active dihydrotestosterone, which has two isoforms; type I expressed in liver, skin and scalp by SRD5A1 located on chromosome 5; and ...

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5α Cholestane

5α Cholestane

... The structure crystallizes in the chiral space group P21 but the absolute structure parameter Flack, 1983 could not be re®ned to an acceptable value as the structure is composed purely o[r] ...

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Statins and Sepsis: Possible Connections and Therapeutic Implications

Statins and Sepsis: Possible Connections and Therapeutic Implications

... mortality continues to increase. A delicate balance exists between widespread triggering of defence mechanism by invading micro-organisms and both direct/indirect effects of the micro-organisms and their products. It has ...

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Role of 5 alpha-reductase inhibitors in the management of prostate cancer

Role of 5 alpha-reductase inhibitors in the management of prostate cancer

... The heterogeneous behavior of prostate cancer as well as multiple factors limiting patient accrual are some of the inherent challenges in the development and completion of clinical trials comparing various therapeutic ...

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Stabilization of Prostate Cancer with Amanita phalloides: Intervals with 5-Alpha-Reductase Inhibitors and Melatonin to Circumvent Resistance: Case Report

Stabilization of Prostate Cancer with Amanita phalloides : Intervals with 5-Alpha-Reductase Inhibitors and Melatonin to Circumvent Resistance: Case Report Isolde Riede 1*

... Presentation of Case: Inhibitors of 5-alpha-reductase were applied in intervals of pausing Amanita. They can further stabilize the prostate antigen level, but tumor cells became resistant to this drug after ...

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INDIAN HERBS THAT ACT AS 5-ALPHA REDUCTASE INHIBITORS

INDIAN HERBS THAT ACT AS 5-ALPHA REDUCTASE INHIBITORS

... Saw palmetto is one of the herbs that block DHT and has been studied extensively. Of particular interest to researchers is the presence of a specific plant sterol found in this herb called beta-sitosterol. The ...

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A Review on Finasteride: A 5-Alpha Reductase Inhibitors, its Mechanism, Facts and Benefits

A Review on Finasteride: A 5-Alpha Reductase Inhibitors, its Mechanism, Facts and Benefits

... FINASTERIDE: USE IN MALE PATTERN HAIR LOSS The 5alpha-reductase inhibitor finasteride blocks the conversion of TT to DHT i.e. testosterone to dihydrotestosterone (DHT), the androgen accountable for male pattern ...

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5α-Reductase inhibitory component from leaves ofArtocarpus altilis

5α-Reductase inhibitory component from leaves ofArtocarpus altilis

... The acetone extract of leaves of Artocarpus altilis showed potent 5a-reductase inhibitory activity.. Fraction- ation guided by 5a-reductase inhibition led to the isol[r] ...

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