A disintegrin and metalloprotease
A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis
... Proteolytic release of transmembrane ectodomains, also termed ectodomain shedding, is an irreversible post- translational mechanism to regulate protein function. Members of the A Disintegrin and ...
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The prognostic value of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13) deficiency in septic shock patients involves interleukin 6 and is not dependent on disseminated intravascular coagulation
... A metalloprotease, ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13), specifically cleaves ULVWF multimers and thus, regulates its adhesive ...
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MicroRNA-552 enhances metastatic capacity of colorectal cancer cells by targeting a disintegrin and metalloprotease 28
... A Disintegrin And Metalloprotease (ADAM) family member 28 (ADAM28) was identified as a target of miR-552, which was further validated in terms of genetic dual luciferase report ...
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The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations
... ated with atopic or non atopic asthma, lung function and BHR in a large nested case control study of German chil- dren (N = 1,872; comparing 624 asthmatics and/or BHR positives and 1,248[r] ...
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Natural compounds targeting major cell signaling pathways: a novel paradigm for osteosarcoma therapy
... A disintegrin and metalloprotease; ALDH: Aldehyde dehydrogenase; APH1: Anterior pharynx defective 1; BCl-2: B cell lymphoma 2; C-ERMAD: Carboxy-ERMAD; CK1 α : Casein kinase 1 alpha 1; DATS: Diallyl ...
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ADAM Family Protein Mde10 Is Essential for Development of Spore Envelopes in the Fission Yeast Schizosaccharomyces pombe
... a metalloprotease of the ADAM (for “a disintegrin and metalloprotease”) ...a disintegrin domain, a cysteine-rich domain, and an epidermal growth factor-like ...
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Original Article ADAM8 promotes gastric cancer cell invasiveness via EGFR/ERK signaling pathway to upregulate matrix metalloproteinases 2 and 9 expression
... a disintegrin and metalloprotease 8; mRNA, messenger RNA; qRT-PCR, quantitative reverse transcription polymerase chain reaction; metastasis GC, metastasis gastric can- cer tissue; no metastasis GC, no ...
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TNF-α and IL-1β-activated human mesenchymal stromal cells increase airway epithelial wound healing in vitro via activation of the epidermal growth factor receptor
... ADAM: a disintegrin and metalloprotease; ALI: air liquid interface; AREG: amphiregulin; BSA: bovine serum albumin; BPE: bovine pituitary extract; CCDN1: cyclin D1; CM: conditioned medium[r] ...
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ADAM 17 is expressed on rheumatoid arthritis fibroblast like synoviocytes and regulates proinflammatory mediator expression and monocyte adhesion
... A disintegrin and metalloprotease family protein; DAB: Chromogen 3,3 ′ -diaminobenzidine; DAPI: 4 ′ ,6-diamidino-2-phenylindole; DAS28: Disease activity score 28; ELISA: Enzyme-linked immunosorbent assay; ...
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The spectrum of renal thrombotic microangiopathy in lupus nephritis
... a disintegrin and metalloprotease with thrombospondin type I repeats 13; aHUS: atypical hemolytic uremic syndrome; AI: activity indices; ANA: antinuclear antibodies; APS: anti-phospholipid syndrome; CFH: ...
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Genetic effects of rs3740199 polymorphism in ADAM12 gene on knee osteoarthritis: a meta-analysis
... A disintegrin and metalloprotease (ADAM), a member of the Zn-dependent metzincin superfamily, is associated with many complex diseases such as heart disease, rheumatoid arthritis, Alzheimer ’ s disease, and ...
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Developments in the scientific understanding of osteoarthritis
... ADAMTS = a disintegrin and metalloprotease with thrombospondin motifs; CCR = C-C chemokine receptor; COMP = cartilage oligomeric matrix protein; COX = cyclo-oxygenase; CTX-II = carboxyl-[r] ...
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The effects of a high carbohydrate and high fat diet and dietary interventions in the molecular tumourigenesis of colorectal cancer
... Colorectal cancer (CRC) is the most commonly diagnosed cancer affecting both men and women in Australia. The Epidermal Growth Factor Receptor (EGFR) plays an important role in the development and progression of CRC. EGFR ...
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Right drug, right patient, right time: aspiration or future promise for biologics in rheumatoid arthritis?
... A disintegrin and metalloprotease 17; AUC: Area under the curve; bDMARD: Biological disease-modifying anti-rheumatic drug; CDAI: Clinical disease activity index; CI: Confidence interval; DAS28: 28-Joint ...
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Effect of cellular factors on the generation of beta amyloid
... a-2 macroglobulin Beta Amyloid Alzheimer’s Disease ‘a disintegrin and metalloprotease’ APP intracellular domain Amylo Anterior pharynx defective-1 Ammonium Peroxydisulphate Alkaline Phos[r] ...
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Biochemistry and Physiological Functions of ADAMTS7 Metalloprotease
... A Disintegrin And Metalloprotease with ThromboSpondin type 1 repeats (ADAMTS) family, was first identified and cloned in 1999 ...a metalloprotease domain, and various lengths of C-terminal domains ...
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Long term follow up of congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome) on hemodialysis for 19 years: a case report
... Case presentation: We report a Japanese patient with congenital TTP (Upshaw – Schulman syndrome) who was followed for 19 years after initiation of hemodialysis when he was 22 years old. At the age of 6 years, the first ...
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Building Positive Future Orientations: The Role of Natural Mentors in the Lives of African American Girls
... A Disintegrin and Metalloprotease 12 Angiopoetin Alkaline Phosphatase Bacilliary Angiomatosis Bartonella adhesion A Bcl2 Antagonist of Death Bcl2 Associated X Protein Bartonella transloc[r] ...
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Immunohaemostasis: a new view on haemostasis during sepsis
... a disintegrin and metalloprotease with thrombospondin type 1 motif; CAS: contact activation system; DIC: disseminated intravascular coagulation; FDPs: fibrin(ogen) degradation products; HDPs: host defence ...
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A conserved metalloprotease mediates ecdysis in Caenorhabditis elegans
... apolysis (that is, in the separation of the cuticle from the hypoderm), no defects in apolysis were observed in nas-37 mutants. It is possible that NAS-37 functions during apolysis but is redundant with other secreted ...
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