The Chicago Approach to business education is based on an essential fact: there are neither enough formulas or business cases to span the range of high-stake decisions faced in the course of a career. We favor fundamental academic disciplines over fads, and develop critical thinkers who can assess any challenge or opportunity. When you choose to advance your education through the AcceleratedDevelopment Program, you learn what others long have known: Chicago Booth is the best source in the world for serious, effective business education.
philip Berger has taught in the Accelerateddevelopment program since the early days of the program seven years ago. he also teaches a course on Accounting and Financial Analysis in the full time MBA in Chicago. dr. Berger’s research interests are mainly in the areas of financial reporting and corporate finance. he has received several research prizes and counts among his publications one of the most widely-cited papers by an accounting professor.
Abstract. In the study, the authors have identified the dominant trends in the development of the international road transport services market. These include monopolization and protectionism, structural imbalances, namely, predominance of European transport companies in the international motor transport market, prevailing of private transport companies. Hence, the researchers determined the general vector of improvement of the motor transport services market in the modern stage of internationalization of global economic relations. The current trends in the development of the international road transport services market in Ukraine are substantiated. The authors propose a competitiveness assessment methodology for transport enterprises. It is proposed to quantify the following elements as part of the competitiveness coefficient of a transport enterprise: 1) the range of offered transportation services; 2) pricing policy; 3) advertising; 4) public relations; 5) sales system; 6) employee incentive system; 7) innovative activity of the enterprise. Using the proposed methodological approach will help making reasonable management decisions to improve the efficiency of transport enterprises, to expand the information base of economic research, and to improve the quality of analysis in the context of accelerateddevelopment of the international logistics infrastructure.
Abstract: Objective: Sclerostin (SOST), acting as a Wnt antagonist, has been shown to play a key role in regulating bone homestasis, and has also been linked to osteoarthritis (OA) development. Here, we investigated whether overexpressing SOST could affect OA development after destabilization of the medial meniscus (DMM) using SOST transgenic (Tg) mice. Methods: Bone and cartilage phenotypes of SOST Tg mice at 10 weeks of age were investi- gated by dual x-ray absorptiometry (DXA) and histology. Subsequently, 10-week-old SOST Tg mice and their wild-type (WT) littermates were subjected to DMM or sham surgery. Knee joints were isolated to evaluate the cartilage dam- age and the subchondral bone plate thickness at 2 and 8 weeks post-surgery. The changes of chondrocyte anabolic and catabolic responses after IL-1β or TNFα stimulation, β-catenin signaling and apoptosis were also measured. Results: Ten-week-old SOST Tg mice were identical to their WT littermate males except that they displayed digit ab- normalities and osteopenic, whereas more severe OA was observed in SOST Tg mice at 2 and 8 weeks post-DMM. In addition, DMM resulted in significantly greater subchondral bone changes compared with sham surgery in SOST Tg mice at 8 weeks post-surgery. The accelerated OA in SOST Tg mice may be associated with reduced β-catenin signaling and increased chondrocyte apoptosis. Conclusion: Overexpressing SOST led to accelerateddevelopment of instability-induced OA. Our data further highlight that cartilage homeostasis requires finely tuned Wnt signaling.
The ideas and results presented in this paper represent our on-going research. Our intention is to continue the definition of the accelerateddevelopment methodology and the corresponding open architecture, composed of languages and tools, supporting the methodology and automating it as far as possible. In particular, we are investigating fast test case construction techniques using SDL tools, implementation of the partial re- engineering approach for SDL, and architecture analysis of legacy telecommunications software. Other future research directions of the Department for CASE tools include extensive case studies aimed at assessing the practical application of various approaches to re-engineering, as well as the combined use of the forward and reverse engineering techniques for improving time to market for typical telecommunication feature development.
Rheumatoid arthritis (RA) is a systemic immune disorder char- acterized by polyarticular joint inflammation and destruction . Increased expression of E-selectin and P-selectin has been observed in inflamed joints from RA patients, with several studies showing significant elevations in soluble selectins in the serum of patients with active disease [7-10]. In addition, several anti-inflammatory drugs have been shown to decrease the expression of E-selectin and P-selectin, as well as that of other adhesion molecules, in joint tissue from patients under- going remission . These findings suggest that the selectins may play an important role in the initiation and/or progression of joint inflammation during RA. However, investigations in ani- mal models have provided inconsistent results concerning the role of selectins in the development of arthritis. For example, antibodies to E-selectin but not P-selectin inhibited adjuvant- induced arthritis in rats , whereas Staphylococcus- induced arthritis was diminished in P-selectin mutant mice and in mice treated with antibodies to L-selectin . Previously, we reported that P-selectin mutant mice exhibited accelerateddevelopment of joint inflammation in the collagen-immunized arthritis (CIA) model compared with wild-type mice . The severity of arthritis and the circulating levels of anti-type II col- lagen antibodies were also increased in P-selectin mutant mice. Further investigations suggested that this effect may result from alterations in leukocyte trafficking and/or cytokine production in lymphoid organs or joint tissue in these mice dur- ing the initiation of CIA .
individuals with these risk factors never experience a stroke. This may suggest that patients who do develop a stroke are more vulnerable to risk factors than those who do not. Consequently, they may also have a higher risk of developing other (cerebro)vascular diseases. A possible marker of the brain’s vulnerability to vascular risk factors is cerebral small vessel disease (SVD). In the elderly, SVD has convincingly been related to vascular risk factors and accelerated cognitive and motor decline. 5–7
Abstract: The capacity for educators to effectively scaffold lessons to maximise student learning in the ‘zone of proximal development’ has for decades been acknowledged as a pre-requisite for academic success. However, no research has attempted to critically evaluate unit curriculum and quantify its effectiveness in guiding students to learn within their individual zone of proximal development. This seems even more important in an accelerated program, where the rapid pace may exacerbate student feelings of anxiety and/or boredom and negatively influence learning outcomes. The proposed research initiative aims to develop a novel method of assessing student learning in the zone of proximal development and apply it to an accelerated program. This information has many important applications including empowering educators to; 1) personalise the learning experience, 2) evaluate the effectiveness of teaching methods, 3) evaluate the capacity for educators to effectively scaffold lessons, and 4) critically review and guide alterations to unit curricula.
The increasing path way of research in pharmaceutical industries has resulted in emergence of novel and competent formulations in market. Some of this dosage forms are highly potent whereas some contain impurities. Such development naturally requires precise, easy and sensitive methods of chemical analysis, as quality is very important in a pharmaceutical product. Since it involves life, unlike other customer goods there can be and there is no second quality in medicines. Quality can be also achieved through the quality control department and quality assurance.
Even though we grapple with different scientific questions, academics in different disciplines all face the same ongoing challenges posed by the globalisation of the scientific labour market, the increased pressure to procure funding, publish and be visible in our respective fields, the precarious and short-term employment opportunities, and the need to adapt our life course and family life to the temporal and spatial demands of the academic professions. The obsession with saving time is a false economy: accelerated academic work is damaging science, and time- pressed career trajectories are damaging individuals.
2014 saw the introduction of our accelerated certification format. Due to the success we had with this model in 2014 we will continue to run it in this format for 2015. The first webinar series for our members in the APAC region will be run at the beginning of March from the 3 rd – 6 th . Calls will commence at 9am (Hong Kong, Shanghai, Singapore Time). Each webinar will run for 90 minutes. Time zone equivalents:
Background: Cardiac toxicity is the foremost reason for drug discontinuation from development to clinical evaluation and post market surveillance [Fung 35:293-317, 2001; Piccini 158:317-326 2009]. The Food and Drug Administration (FDA) has rejected many potential pharmaceutical agents due to QT prolongation effects. Since drug development and FDA approval takes an enormous amount of time, money and effort with high failure rates, there is an increased focus on rescuing drugs that cause QT prolongation. If these otherwise safe and potent drugs were formulated in a unique way so as to mitigate the QT prolongation associated with them, these potent drugs may get FDA approval for clinical use. Rescuing these compounds not only benefit the patients who need them but also require much less time and money thus leading to faster clinical translation. In this study, we chose curcumin as our drug of choice since it has been shown to posses anti-tumor properties against various cancers with limited toxicity. The major limitations with this pharmacologically active drug are (a) its ability to prolong QT by inhibiting the hERG channel and (b) its low bioavailability. In our previous studies, we found that lipids have protective actions against hERG channel inhibition and therefore QT prolongation.
HPLC method was developed and validated using ICH Q2R1 guidelines for the determination of SIM percent release in different generic and innovator tablets. It was demonstrated that the USP UV-Vis method is not suitable to assess the dissolution kinetic profiles and to perform a comparative study between the innovator and different generics of simvastatin. This UV-visible method cannot distinguish between the SIM as principal active ingredient and its impurity A obtained by hydrolysis at the dissolution medium test. While it was demonstrated that the HPLC method is more suitable to quantify accurately and precisely the percent release of the innovator and the generics for simvastatin under normal and accelerated conditions
example, that involvement of the audit committee, board of directors, lawyers, auditors, and outside experts in the annual report review process could be meaningfully reduced under the 60-day deadline. 58 Some commenters cautioned that a shortened deadline may increase the chance of error. 59 One commenter noted that issuers may have an increased incentive to use recasted language or limited analysis in the Management’s Discussion and Analysis section of the reports when pressured to meet a rigid deadline. 60 Second, some commenters reasoned that companies’ more frequent filing of current reports on Form 8-K, 61 as well as the shortened Form 8-K filing deadline, has reduced the need for further acceleration of the Form 10-K deadline. 62 Third, a number of commenters pointed out the difficulties in meeting the accelerated deadline given the time and costs involved in complying with various regulatory demands, including the requirements regarding internal control over financial reporting mandated by Section 404 of the Sarbanes-Oxley Act of 2002. 63 In addition, commenters claimed that the accelerated deadline will increase costs without incremental benefit, 64 and some commenters claimed that the deadline will impose stress and strain on those responsible for preparing the
Sometimes, career opportunities present themselves when you least expect it. You might not be ready and you certainly do not have one or two years to prepare yourself. What you need is to familiarise yourself with management tools and techniques quickly! A fast and intensive track to leadership. On the corporate level, training needs for this target population are also becoming vital. Retaining people is now as important as finding it. To do so, more attention is now given to career development and management. Companies look for target-group oriented learning and for short or accelerated training opportunities for their high-potential staff.
Given a dataset with c natural clusters, an FCM variant can be accelerated further by reducing n, s, or i. There are techniques for reducing the number of features, s, but many of these techniques preprocess the data rather than being integrated into the algorithm itself  . An alternative technique, subspace clustering, looks for clusters using a subset of the available features  . Each cluster found can use a different subset of the available features. This line of research, however, was not pursued. My dissertation focused on techniques that reduce the amount of data used, n, and the number of iterations, i.
Safe and effective technological improvements in orthognathic and orthodontic procedures, including sophisticated 3D treatment planning, tissue engineering and office-based orthognathic surgery, make it possible for physicians to treat both common and challenging deformities. These technological advancements require practitioners to expand their knowledge and competency to offer accelerated, affordable, convenient and predictable care to their patients. Doing so will also reach more patients who need treatment.