Accelerated senescence
Telomerase prevents accelerated senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts
... The accelerated cellular senescence characteristic of G6PD-deficient fibroblasts would seem to represent a clear case of a senescence mechanism based on accumu- lated oxidative DNA damage rather than ...
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Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence
... of accelerated senescence and osteopenia (SAMP6) to test the hypothesis that reduced osteoblastogenesis is linked with decreased bone ...controls, senescence-accelerated mice failed to ...
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Linking a role of lncRNAs (long non-coding RNAs) with insulin resistance, accelerated senescence, and inflammation in patients with type 2 diabetes
... and senescence and their expression levels correlated to poor glycemic control, insulin resistance, accelerated sen- escence, and ...in accelerated aging [4, ...cellular senescence, ...
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Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
... cells have a higher rate of cell turnover or are exposed to more stress than articular chondrocytes in vivo. Indeed, the degen- erative process in IVD begins as early as the second decade of life, with associated ...
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Immunohistochemical localization of NGF, BDNF, and their receptors in a normal and AMD-like rat retina
... Male senescence-accelerated OXYS rats at preclinical (age 20 days), early (3 months), and late (18 months) stages of the disease (four per each age group) and age-matched male Wistar rats (as controls) were ...
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Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
... cellular senescence and accelerated senescence in the degenerate IVD and that this is associated with increased catabolic cell ...Cellular senescence can be prevented, bypassed, or reversed in ...
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Caveolin 1 expression and stress induced premature senescence in human intervertebral disc degeneration
... described accelerated senescence (characterised by a variety of biomarkers, includ- ing reduced cell replication potential, elevated levels of the cell cycle inhibitor p16 INK4a , increased SA-β-gal ...
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The anti-aging effects of LW-AFC via correcting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strain
... inflammatory cytokines, leading to a chronic, low-grade, pro-inflammatory condition named “inflammaging” [27, 29, 72, 73]. Elevated concentration of pro-inflammatory cytokines and decreased level anti-inflammatory ...
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Rcor2 underexpression in senescent mice: a target for inflammaging?
... of accelerated aging and ...of accelerated aging such as loss of activity, skin coarseness, alopecia, lack of hair glossiness, increased lordokyphosis, periophthalmic lesions, and systemic senile ...
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Effects of chronic noise exposure on the microbiome-gut-brain axis in senescence-accelerated prone mice: implications for Alzheimer’s disease
... Axis-series studies showed that endothelial tight junction proteins were decreased in both the intestine and brain, whereas serum neurotransmitter and inflammatory mediator levels were e[r] ...
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Resveratrol counteracts bone loss via mitofilin-mediated osteogenic improvement of mesenchymal stem cells in senescence-accelerated mice
... mitochondrial genomes, the nuclear compartment of which include the mitochondrial transcription factor A (Tfam) and general biogenesis regulators like Pgc-1 and Ampk [71, 121, 122]. With advanced age, ...
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Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study
... also express CB2 reduces detectable radioactivity. Re- cently, we reported that [ 11 C]NE40 binding is increased in the peri-infarct area of the ipsilateral cortex at 24 h after induction of stroke, but not in the ...
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The antioxidative defense system is involved in the premature senescence in transgenic tobacco (Nicotiana tabacum NC89)
... mutants and transgenic plants with altered growth and development. For example, the hmg1 mutant exhibits dwarfing, early senescence, sterility, and earlier induc- tion of the senescence-associated 12 ...
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PubMedCentral-PMC5452723.pdf
... triggers senescence in other parts of the ...of senescence genes and inhibition of Stat3 ...with senescence, Stat3 activa- tion, and the manifestation of ...
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NOX4 downregulation leads to senescence of human vascular smooth muscle cells
... premature senescence (SIPS) of vascular smooth muscle cells (VSMCs) induced by doxorubicin or H 2 O 2 , correlates with increased level of DSB and ...replicative senescence were accompanied by diminished ...
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Coming of age: molecular drivers of aging and therapeutic opportunities
... cellular senescence and functional ...The senescence theory of aging suggests that replication-competent cells become exhausted and enter a permanent state of growth arrest called “cel- lular ...
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The Senescence of Spermatozoa
... of the organisation of the cell or to a depletion of its energy if two assumptions are made: i the cells or elements within the cells comprise a heterogeneous population in the sense tha[r] ...
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Is senescence-associated β-galactosidase a marker of neuronal senescence?
... As SA-β-gal-positive cells appeared in culture much earlier than REST-positive cells we think that, contrary to REST expression, SA-β-gal activity cannot be considered as a specific marker of their senescence- ...
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PubMedCentral-PMC4938009.pdf
... Also of potential interest is the finding that chondrocytes have an intrinsic circadian clock which is disrupted in cartilage from aged mice 56 . A decline in expression of the circadian clock gene BMAL1 (also known as ...
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Original Article Ganoderma lucidum polysaccharides improve renal aging through upregulating SIRT1 expression
... cellular senescence, which is defined as the reduction of cell proliferation even in the pres- ence of ample space, nutrients, and growth factors in the culture [5, ...lar senescence and fibrosis is ...
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