acetyl carnitine
Effects of L-carnitine and L-acetyl-carnitine on testicular sperm motility and chromatin quality
... of carnitine in mitochondrial lipid peroxidation and its anti- oxidative effects, this study was designed to investigate the effects of L-carnitine and L- acetyl-carnitine on testicular sperm ...
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Behaviour and Degenerative Changes in the Basal Forebrain Systems of Aged Rats (12 Months Old) after Levo Acetyl Carnitine Treatments
... choline acetyl transferase (ChAT+) labeling using the peroxidase antiperoxidase (PAP) technique with a ChAT monoclonal antibody (1:4) prepared in rats (Boehringer Mannheim, ...
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Role of Carnitine Acetyltransferases in Acetyl Coenzyme A Metabolism in Aspergillus nidulans
... of acetyl-CoA formed by  -oxidation in peroxisomes to acetyl-carnitine is essential for fatty acid utilization and that cytoplasmic FacC or AcuJ cannot replace this ...substrate acetyl-CoA, ...
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Carnitine-Dependent Transport of Acetyl Coenzyme A in Candida albicans Is Essential for Growth on Nonfermentable Carbon Sources and Contributes to Biofilm Formation
... the acetyl-CoA is produced in the ...to acetyl-CoA, it is conceiv- able that the acetyl units must be linked to carnitine to allow their transport over the peroxisomal and mitochondrial mem- ...
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Mitochondrial Carnitine-Dependent Acetyl Coenzyme A Transport Is Required for Normal Sexual and Asexual Development of the Ascomycete Gibberella zeae
... and carnitine-dependent transport of peroxisomal acetyl-CoA are important to ...of carnitine-dependent acetyl-CoA transport in the ...CAT1, carnitine acetyltransferase 1 (FGSG_01924.3); ...
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Requirements for Carnitine Shuttle Mediated Translocation of Mitochondrial Acetyl Moieties to the Yeast Cytosol
... and acetyl-carnitine translocase (18, 19, 29, ...the carnitine shuttle can translocate acetyl units from mitochondria to cytosol, a strain was con- structed in which provision of cytosolic ...
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Arthritis and pain Future targets to control osteoarthritis pain
... mGluR2/3 receptor activation appears necessary to reduce nerve terminal excitability and to modulate pain transmission since treatment with the agonist L-acetyl carnitine reduced inflamm[r] ...
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Carnitine and acylcarnitine metabolism during exercise in humans Dependence on skeletal muscle metabolic state
... free carnitine content decreased 66%, and muscle total carnitine content decreased by 19% (all P less than ...muscle carnitine metabolism were present at the completion of 30 min of high-intensity ...
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Acetyl-L-Carnitine downregulates invasion (CXCR4/CXCL12, MMP-9) and angiogenesis (VEGF, CXCL8) pathways in prostate cancer cells: rationale for prevention and interception strategies
... ALCAR: Acetyl-L-carnitine; ANG: Angiogenin; BPH: Benign prostatic hyperplasia; CCL2: C-C Motif Chemokine Ligand 2; CCR2: C-C chemokine receptor type 2; CM: Conditioned media; CXCL12: C-X[r] ...
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Primary preventive and secondary interventionary effects of acetyl L carnitine on diabetic neuropathy in the bio breeding Worcester rat
... with acetyl-L-carnitine had no effects on nerve polyols, but corrected the Na+/K+ -ATPase defect and was associated with 63% prevention of the nerve conduction defect and complete prevention of structural ...
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A randomised controlled trial of a mitochondrial therapeutic target for bipolar depression: mitochondrial agents, N-acetylcysteine, and placebo
... comprised acetyl L -carnitine (ALC), ubiquinone (coenzyme Q10), and alpha lipoic acid (ALA), in addition to co-factors involved in mitochon- drial ...
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Effects of carnitine on oxidative stress response to intravenous iron administration to patients with CKD: impact of haptoglobin phenotype
... received Carnitine (20 mg/kg, IV) prior to ...of Carnitine with IVIR abolished the IVIR-induced oxidative stress as evident by preventing the elevations in AOPP and NGAL, preferentially in patients with ...
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Carnitine supplementation to obese Zucker rats prevents obesity-induced type I to type II muscle fiber transition and favors an oxidative phenotype of skeletal muscle
... obese carnitine group than in the obese control ...obese carnitine group is therefore in line with the induction of PGC-1α and PGC-1β and provides a further indication for the improved oxidative phenotype ...
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Prevalence of Carnitine Deficiency and Decreased Carnitine Levels in Patients on Peritoneal Dialysis
... Data are shown as mean ± SD or median (interquartile range) as appropriate. Continuous variables were compared using the Student t test or Mann–Whitney U test. Categorical variables were compared using the chi-square ...
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Production of 3 hydroxypropionate from biomass
... In this study E. coli and R. rubrum were genetically engineered to produce 3HP from glucose or syngas respectively. This was done by introduction of a single enzyme Malonyl- CoA Reductase (MCR). C. aurantiacus MCR has ...
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L Carnitine Contents in the Tissues of Rabbits Fed Urea as an Alternative of Dietary Protein
... the carnitine contents of epididymal spermatozoa in an organ culture containing 25 mM of L-carnitine, and they proposed that the accumula- tion of carnitine supported sperm maturation; however, there ...
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Kinetic compartmental analysis of carnitine metabolism in the human carnitine deficiency syndromes Evidence for alterations in tissue carnitine transport
... muscle carnitine deficiency (MCD), and four patients with primary systemic carnitine deficiency ...of carnitine into muscle in both forms of primary carnitine ...of carnitine transport ...
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Diosgenin ameliorates palmitic acid induced lipid accumulation via AMPK/ACC/CPT 1A and SREBP 1c/FAS signaling pathways in LO2 cells
... AMP-activated protein kinase (AMPK) is believed to play a central role in controlling lipid metabolism by modulating the downstream acetyl-CoA carboxylase (ACC) and CPT1 pathway [11]. ACC catalyzes the production ...
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Effect of oral acetyl L-carnitine arginate on resting and postprandial blood biomarkers in pre-diabetics
... mote significant changes in other metabolic or oxidative stress variables measured at rest or post meal. The increase in fasting nitrate/nitrite was influenced primarily by eight of the fourteen subjects receiving ALCA ...
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The Possible Mechanisms Involved in the Protection Strategies against Radiation Induced Cellular Damage by Carnitines
... form, acetyl-L-carnitine, demonstrate antioxidative properties, protect- ing cells against lipid peroxidation and membrane breakdown [14] ...and acetyl-L-carnitine are able to protect against ...
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