activin A receptor type I
The effect of type 2 diabetes mellitus and obesity on muscle progenitor cell function
... ACVR1: Activin A receptor type I; AKT: Also known as protein kinase B; AMPK: AMP-activated protein kinase; aP2: Adipocyte protein 2; bFGF: Basic fibroblast growth factor; BMP: Bone ...
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Hypoplasia of pancreatic islets in transgenic mice expressing activin receptor mutants
... signaling, activin requires two types of receptors containing the serine/threonine kinase domain, ac- tivin receptor type I (ActR I) and type II (ActR II), as well as the ...
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Hemodynamic and genetic analysis in children with idiopathic, heritable, and congenital heart disease associated pulmonary arterial hypertension
... protein type II receptor (BMPR2) gene, 2 Activin A receptor type II-like kinase-1 (ACVRL1) mutations and one Endoglin (ENG) mutation were found in the 29 I/HPAH ...
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Mice overexpressing growth hormone exhibit increased skeletal muscle myostatin and MuRF1 with attenuation of muscle mass
... insulin receptor β, IRS1 (Ser307), mTOR (Ser2448), mTOR total, p70 S6 kinase (Thr389), p70 S6 kinase total, 4E-BP1 (Thr37/46), 4E-BP1 total, p38 (Thr180/Tyr182), p38 total, p44/42 (Thr202/Tyr204), p44/42 total, ...
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Natural history of fibrodysplasia ossificans progressiva: cross-sectional analysis of annotated baseline phenotypes
... Fibrodysplasia Ossificans Progressiva (FOP) (OMIM #135100) is a rare, severely disabling disease character- ized by malformed big toes and progressive heterotopic ossification (HO) in muscles, tendons, and ligaments, and ...
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A Soluble Activin Receptor Type IIB Does Not Improve Blood Glucose in Streptozotocin-Treated Mice
... the type II activin receptors, particularly activin receptor type IIB (ACVR2B) ...a type I receptor, activin-like kinase (ALK) 4 or 5, to initiate signal ...
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Regulation of TGF-β receptor activity
... , activin, Nodal, bone morphogenetic proteins (BMPs) and others, play vital roles in development, tissue homeostasis and some diseases development ...the type II (TbRII) and type I (TbRI) ...
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Growth factor regulation of proliferation and survival of multipotential stromal cells
... a type II serine–threonine kinase receptor recruiting another such transmembrane protein (receptor ...I). Receptor I phosphorylates the primary intra- cellular downstream ...
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Activin signaling as an emerging target for therapeutic interventions
... antagonizes activin by forming a complex of ActRIIs and betaglycan [2,4](Figure ...BMP type I receptor, which increase BMP signaling ...the activin and BMP pathway are therapeutic ...
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Activin-A up-regulates type I activin receptor mRNA levels in human immortalized extravillous trophoblast cells.
... that activin- A stimulates, while inhibin-A inhibits, ActRI mRNA ...by activin-A. The time course of the activin-A ef- fect on ActRI mRNA showed responses at 3 to 12 hours af- ter treatment, with a ...
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PD-L1 and PD-L2 expression correlated genes in non-small-cell lung cancer
... Non-small-cell lung cancer (NSCLC), the most com- mon form of lung cancer, is a heterogeneous disease with adenocarcinoma and squamous cell carcinoma being the predominant molecular subtypes [1]. Antibody- mediated ...
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Interleukin 1 Induces HIV-1 Expression in Chronically Infected U1 Cells: Blockade by Interleukin 1 Receptor Antagonist and Tumor Necrosis Factor Binding Protein Type 1
... IL- I receptor antagonist inhibits IL- 1 -induced cytokine synthesis and blocks the binding of IL-I to its type II receptor on human mono-. cytes[r] ...
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Low-intensity pulsed ultrasound prevents muscle atrophy induced by type 1 diabetes in rats
... Protein kinase B (Akt), a serine/threonine kinase, is recruited to the membrane by an interaction with phos- phoinositide docking sites for full activation [22]. Activated Akt mediates downstream responses, includ- ing ...
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Treatment with soluble activin type IIB receptor improves bone mass and strength in a mouse model of Duchenne muscular dystrophy
... μCT. Activin A has been shown to induce osteoclast differentiation in vitro and in vivo [32 – 35], although some reports suggest a negative effect on survival and motility of mature osteoclasts ...for ...
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Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension
... (the receptor for CCL2) is necessary for expression of mouse IL6 protein that is increased by experimentally induced sepsis in mouse [49], and IL1 protein increases expression of CCL2 pro- tein ...IL-1 ...
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Identification of a bone morphogenetic protein type 2 receptor neutralizing antibody
... Objective: The bone morphogenetic protein (BMP) signaling pathway comprises the largest subdivision of the trans- forming growth factor (TGFβ) superfamily. BMP signaling plays essential roles in both embryonic ...
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Cannabinoid Receptor Type I Modulates Alcohol-Induced Liver Fibrosis
... CB2 receptor status and its activation to- ward alcohol-mediated liver injury was further underscored by showing that mice fed an alcoholic liquid diet contain- ing ...
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A synthetic peptide derived from the sequence of a type I collagen receptor inhibits type I collagen mediated platelet aggregation
... cloned receptor inhibits the type I col- lagen–induced platelet aggregation and the release of ATP in a dose-dependent ...platelet type III collagen receptor ...types I and III ...
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Hemagglutinin of Influenza A Virus Antagonizes Type I Interferon (IFN) Responses by Inducing Degradation of Type I IFN Receptor 1
... circumvent type I interferon (IFN) responses, particularly by inhibiting the synthesis of type I ...the type I IFN receptor (IFNAR)-mediated signaling ...the type ...
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Cytokine-Independent Upregulation of MDA5 in Viral Infection
... binding sites in the murine IP10 and IFN- ␣ 4 promoters were com- pared with putative IRF3 binding sites in the murine and human MDA5 promoter regions. Boxes highlight GAAA motifs required for IRF3 binding. (b) ...
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