Acute lung inflammatory injury
Requirement and role of C5a in acute lung inflammatory injury in rats
... neutrophil-dependent lung injury have been well established, it has not been clear pre- cisely which activation products of complement are involved in these inflammatory models of lung ...of ...
11
Antenatal and postnatal corticosteroid and resuscitation induced lung injury in preterm sheep
... to lung injury and systemic inflammatory ...the lung injury and improved ventilation, lung inflamma- tion and systemic changes in acute phase responses in the liver still ...
11
Ex vivo lung perfusion as a human platform for preclinical small molecule testing
... The acute respiratory distress syndrome (ARDS) is a disease process that is often associated with infec- tion, evolves rapidly, and confers a very high mortality on the afflicted (1, ...overzealous ...
13
Intratracheal synthetic CpG oligodeoxynucleotide causes acute lung injury with systemic inflammatory response
... liver injury on day 1, which was characterized by sinusoidal leukostasis, deterioration of the microcircula- tion, and hepatocyte apoptosis ...the lung into the blood ...cause acute lung ...
9
Original Article Glucocorticoid receptorβ isoform exhibits a disproportionate increase over the α isoform in the lungs of a polytrauma rat model
... and lung tissue and blood samples were collected for ...the lung was stained with hematoxylin and eosin, and lung myeloperoxidase activ- ity was measured with a myeloperoxidase assay ...and ...
6
Induction of heme oxygenase 1 by hemin protects lung against orthotopic autologous liver transplantation induced acute lung injury in rats
... reducing inflammatory stress ...in lung disease models both in vivo and vitro, including ALI, ischemia–reperfusion-induced lung injury, lung cancer and asthma ...the lung against ...
9
Increased effort during partial ventilatory support is not associated with lung damage in experimental acute lung injury
... structural injury (alveolar damage score) and biochemical ...the lung, may be problematic. The fact that some, but not all inflammatory markers (IL1β, TNF-α) had concentra- tions similar in BALF and ...
13
Predictors of the therapeutic effect of sivelestat in patients with acute lung injury associated with systemic inflammatory response syndrome
... Sivelestat is a selective NE inhibitor, which binds directly to NE and inactivates it by a reversible acylation- deacylation mechanism [4 – 6]. In addition, it relaxes vas- cular smooth muscle [7]. Sivelestat was ...
5
MEK1 regulates pulmonary macrophage inflammatory responses and resolution of acute lung injury
... to lung injury and its resolution by their unique functional heterogeneity and plasticity (2, ...of lung injury. During resolution of lung injury, these cells repolarize, and ...
17
Anti-inflammatory effects of novel curcumin analogs in experimental acute lung injury
... After LPS incubation, TLR4 signaling was initiated, thus leading to the activation of NF-kB and MAPK [39]. NF-κB is a nuclear transcription factors that controls tran- scription of DNA [40]. Many researchers have ...
13
Biphasic positive airway pressure minimizes biological impact on lung tissue in mild acute lung injury independent of etiology
... inflammatory mediators, apoptosis, fibrogenesis and bio- chemical markers of epithelial and endothelial cell injury decreased during BIVENT compared to PCV, but did not differ between varying rates of ...
17
Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis
... Bcl3 limits G-CSF–mediated emergency granulopoiesis. (A) Left: Representative FACS analysis (n = 3). Numbers denote percent abundance of peripheral blood granulocytes at 24 hours following B6 → B6 (Bcl3 –/– ) or B6 → B6 ...
13
Original Article Trimetazidine protects against LPS-induced acute lung injury through mTOR/SGK
... LPS, a major component of the outer mem- brane of gram-negative bacteria, to induce pul- monary inflammation [20-23], simulate ALI/ ARDS in A549 cell. Cells were treated with LPS for 2 h following by TMZ treatment for 2 ...
8
The Pattern of Early Lung Parenchymal and Air Space Injury Following Acute Blood Loss
... In these experiments, we found that acute lung injury following hemorrhage and resuscitation was 1.4 characterized by increased inflammatory cell content and the accumulation of intravas[r] ...
7
Bioinformatics insights into acute lung injury/acute respiratory distress syndrome
... of inflammatory cells, cytokine release and so ...to injury and repair which cannot distinguish the type of lung injury across different ...the injury-specific pattern, thus may ...
9
Lung injury prediction score for the emergency department: first step towards prevention in patients at risk
... ventilator-associated lung injury ...of inflammatory cytokines, which compromise the alveolar capillary membrane when increased volumes are applied to the lung ...normal lung to a ...
11
The role of toll-like receptors in acute and chronic lung inflammation
... an inflammatory response or productive infection is likely to ...an acute inflammatory response in these circumstances, the lung epithelium, myeloid cells, and associated lym- phoid tissue are ...
14
Beyond volutrauma in ARDS: the critical role of lung tissue deformation
... stantial lung damage ...the lung infl ammatory response or outcome between low Vt or high Vt with short ventilatory times (from 1 to 3 hours) [23,24], but found that high Vt increases proinfl ammatory ...
7
Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death
... cancer, acute respiratory distress syndrome (ARDS), chronic obstructive pulmon- ary disease (COPD), and asthma, identification of subphenotypes has led to insights into their pathogenesis and the development of ...
11
Impact of non neurological complications in severe traumatic brain injury outcome
... head injury (lower GCS scores) but not with specific anatomic lesions diagnosed by cranial CT scans ...of lung collapse and con- solidation, prevention of lung infection, and acceleration of weaning ...
7