acute T cell-mediated rejection
Landscape of innate immune system transcriptome and acute T cell–mediated rejection of human kidney allografts
... Transmembrane and cytosolic pattern recognition receptors in TCMR. We first analyzed the expression of mRNAs for pattern recognition receptors (PRRs), the cornerstone of the innate immune system, in TCMR and Normal ...
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Rationale and design of the RIACT–study: a multi center placebo controlled double blind study to test the efficacy of RItuximab in Acute Cellular tubulointerstitial rejection with B cell infiltrates in renal Transplant patients: study protocol for a randomized controlled trial
... of acute T-cell mediated rejection may be suboptimal in many ...the T-cell mediated tubu- lointerstitial rejections additionally contain a significant number of ...
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Novel immunotherapies for adult patients with B-lineage acute lymphoblastic leukemia
... CAR T therapy If CAR T could be durably detected in the recipients, the chances of relapse would decrease ...CAR T was associated with CD19+ relapse with a hazard ratio (HR) of 34 (p = ...CAR ...
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Quantitative characterization of T-cell repertoire and biomarkers in kidney transplant rejection
... T cell-mediated rejection (TCMR) is the most com- mon cause of acute rejection [12], and is a major cause of allograft dysfunction and failure ...of rejection as early as ...
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Transplant biopsy beyond light microscopy
... on rejection (T cell mediated and antibody-mediated) and the assessment of acute tissue injury, especially in the context of predicting organ function immediately post ...
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Prevention trumps treatment of antibody mediated transplant rejection
... many T cell–mediated immune responses include a B cell com- ponent, the impact of B cell depletion may extend beyond suppression of measurable antibody (9), as is suggested by the ...
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“Acute kidney dysfunction with no rejection” is associated with poor renal outcomes at 2 years post kidney transplantation
... after clinically excluding common causes for AKI in KTR, like dehydration, CNI toxicity or BK virus ne- phropathy. Note that we found 53 cases with strictly normal histology (57%). From a histological point of view, ADNR ...
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CD4 T cell–mediated cardiac allograft rejection requires donor but not host MHC class II
... CD4 T-cell recognition of donor antigens in the context of recipient MHC class II is not sufficient for acute rejec- ...CD8 T cell–depleted hosts can mount a CD4-dependent indirect ...
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Treatment of acute antibody-mediated rejection using Rituximab
... Depletion of naive B-cells by rituximab has been reported which is the main reason why rituximab is relatively successful in AMR treatment (7, 14). It is said that this agent does not have any effect on plasma cells; so ...
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Deletion of Smad3 improves cardiac allograft rejection in mice
... allograft rejection as detected by a marked inhibition of the transcriptional factor RORγt and its signature cytokine IL-17A in the donor ...in acute allograft rejection ...IL-17-producing T ...
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Bronchus associated lymphoid tissue–resident Foxp3+ T lymphocytes prevent antibody mediated lung rejection
... of rejection (Supplemental Figure ...during acute cellular rejection (Supplemental Figure 1, B and ...club cell secretory protein (CCSP) (Figure ...
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CD4+ T-cell Mediated Microvascular Endothelial Cell Death and Chronic Cardiac Allograft Rejection Involves Necroptosis
... accidental cell death as a result of nonspecific stress factors such as extreme heat, freeze-thawing, or osmotic ...in acute allograft rejection, 162 while skin allografts deficient for HSP70 also ...
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... of acute rejec- tion while sparing major other elements of nonspecific host ...anti-T cell antibody preparations, and more recently mycophenolate mofetil, resulting in overall efficacy and ...
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Cell adhesion-mediated mitochondria transfer contributes to mesenchymal stem cell-induced chemoresistance on T cell acute lymphoblastic leukemia cells
... in T-ALL cells [63]. As a result, ROS levels are higher in T-ALL cells than in non- leukemic ...leukemia cell deaths, the induction of intracellular oxidative stress has been shown to be an important ...
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Critical roles of Bim in T cell activation and T cell–mediated autoimmune inflammation in mice
... (17). T cells, B cells, granulocytes, and monocytes are increased 2- to 4-fold in peripheral tissues compared with those in WT ...autoreactive T cells in the thymus ...
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Defining housekeeping genes suitable for RNA-seq analysis of the human allograft kidney biopsy tissue
... The HKG proposed in this study have been vali- dated with reference to publicly available external gene expression datasets obtained on an independent platform, namely, the Affymetrix DNA microarray analysis system. ...
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Acute Renal Endothelial Injury During Marrow Recovery in a Cohort of Combined Kidney and Bone Marrow Allografts
... by acute renal dysfunction and sometimes fever and fluid retention that developed characteristically at the time of recipient marrow ...was acute allograft endothelial injury with little or no cellular ...
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Recent advances in regulatory T cell therapy of autoimmunity, graft rejection and cancer
... Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a close relative of CD28, which is up regulated on T cells following ...on T lymphocytes binds to both CD80 and CD86 on antigen-presenting ...
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Sirtinol regulates the balance of Th17/Treg to prevent allograft rejection
... They inhibit IL-2 synthesis to prevent the activation and proliferation of T lymphocytes. However, the effect of inhibiting Th17 cells is not achieved because of the dif- ferent activation mechanism of Th17 cells. ...
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Cell mediated immunity in acute and chronic hepatitis
... with acute and chronic hepatitis are less cytotoxic when incubated with autologous and homologous HB2Ag-positive and -negative AH, CAH, and CPH are as cytotoxic as normal controls when stimulated with a ...
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