adenosine deaminase that act on RNA
Adenosine Deaminase Acting on RNA 1 (ADAR1) Suppresses the Induction of Interferon by Measles Virus
... double-stranded RNA (dsRNA) binding proteins with enzymatic activities: the protein kinase regulated by RNA (PKR) and the adenosine deaminase acting on RNA ...
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Adenosine Deaminase Acting on RNA 1 Associates with Orf Virus OV20.0 and Enhances Viral Replication
... its RNA-editing activity and that in turns inhibits PKR activation ...disrupts RNA structures, which can lead to either enhanced or reduced virus growth ...the RNA replication of human hepatitis C ...
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Mechanism of interferon action: functionally distinct RNA-binding and catalytic domains in the interferon-inducible, double-stranded RNA-specific adenosine deaminase.
... negative-stranded RNA viruses (6) as exemplified by modification of measles virus RNA (7), but also in other virus types as exemplified by modification of retroviral RNA ...certain adenosine ...
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Modification of retroviral RNA by double-stranded RNA adenosine deaminase.
... double-stranded RNA (dsRNA) unwinding and modify- ing activity was originally found in Xenopus oocytes that had been injected with antisense RNA (1, ...dsRNA adenosine deaminase (dsRAD), ...
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Elevated signal transducers and activators of transcription 1 correlates with increased C C motif chemokine ligand 2 and C X C motif chemokine 10 levels in peripheral blood of patients with systemic lupus erythematosus
... ADAR: adenosine deaminase acting on RNA; ANA: antinuclear antibody; ANCOVA: analysis of covariance; AsA: Asian Americans; BSA: bovine serum albumin; CCL2: C-C motif chemokine ligand 2; CXCL10: C-X-C ...
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Double-Stranded RNA Adenosine Deaminase ADAR-1-Induced Hypermutated Genomes among Inactivated Seasonal Influenza and Live Attenuated Measles Virus Vaccines
... requires RNA editing by ADAR-1L as an essential part of its life cycle ...edited RNA viral genomes have remained few and far be- tween, being confined mainly to negative-stranded viruses such as influenza ...
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Adenosine deaminase deficiency: a review
... of adenosine and 2’deoxyadenosine into inosine and 2’deoxyinosine respect- ...substrates. Adenosine primarily derives from break- down of adenosine triphosphate (ATP) and RNA, and 2 ’ ...
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Development of Improved Adenosine Deaminase Retroviral Vectors
... Comparison of different packaging cell lines. Having iden- tified ADA(MPSV) as the best clone, we next used superna- tant from this clone to transduce FLYA13 and FLYRD18 cells. Plating these cells in limiting dilution ...
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Adenosine deaminase messenger RNAs in lymphoblast cell lines derived from leukemic patients and patients with hereditary adenosine deaminase deficiency
... lymphopenia with severe combined immunodeficiency disease. Cells from patients with ADA deficiency contain less than normal, and sometimes undetectable, amounts of ADA catalytic activity and ADA protein. The molecular ...
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Host Response to Polyomavirus Infection Is Modulated by RNA Adenosine Deaminase ADAR1 but Not by ADAR2
... Mouse polyomavirus (PyV) is a small DNA virus, possessing an ⬃ 5-kb double-stranded circular DNA genome within naked virions whose capsid is formed by three proteins, VP1, VP2, and VP3 (3, 21). In mouse cells permissive ...
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Reduced levels of CCL2 and CXCL10 in systemic lupus erythematosus patients under treatment with prednisone, mycophenolate mofetil, or hydroxychloroquine, except in a high STAT1 subset
... ADAR, adenosine deaminase acting on RNA; CCL2, C-C motif chemokine ligand 2; CXCL10, C-X-C motif chemokine 10; dsDNA, double-stranded DNA; IFN, interferon; SLE, systemic lupus erythematosus; STAT1, ...
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Regulating STING in health and disease
... ADAR1: Adenosine deaminase acting on RNA 1; AGS: Aicardi-goutières syndrome; AMFR: Autocrine motility factor receptor; AMPK: Adenosine monophosphate activated protein kinase; ANA: Antinuclear ...
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Paradoxical expression of adenosine deaminase in T cells cultured from a patient with adenosine deaminase deficiency and combine immunodeficiency
... with adenosine deaminase (ADA) deficiency expressed ADA activity in the normal range, inconsistent with her severe immunodeficiency, metabolic abnormalities, and with the absence of ADA activity in her B ...
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The antiinflammatory mechanism of methotrexate Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation
... raised adenosine concentrations in exudates from carrageenan-inflamed air pouches, and markedly inhibited leukocyte accumulation in inflamed air ...of adenosine deaminase (ADA) into the air pouch, ...
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Volume 4 | Issue 2 - 2014
... increment of purification level of isolated ADA from a Plasmodium yoelii like many other parasitic protozoans is deficient of having the advantage of the de novo pathway for purine biosynthesis and starkly acts upon the ...
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Cerebral Lymphoma in an Adenosine Deaminase–Deficient Patient With Severe Combined Immunodeficiency Receiving Polyethylene Glycol–Conjugated Adenosine Deaminase
... sine deaminase (PEG-ADA) provides an alternate ther- apy to mismatched stem cell transplantation for patients with ADA-deficient severe combined immunodefi- ...
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Adiponectin hormone, adenosine deaminase enzyme and insulin adiponectin hormone, adenosine deaminase enzyme and insulin hormone levels in type 2 diabetic iraqi patients
... mostly by adipocytes and is important regulator of lipid and glucose metabolism. It is established that adiponect in is an insulin-sensitizing hormone with anti-diabetic, anti- inflammatory and anti- atherogenic ...
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Genetic heterogeneity in partial adenosine deaminase deficiency
... Thus, GM 4396 has an enzyme with increased anodal electrophoretic mobility, decreased, more acidic isoelectric point and relatively normal heat stability, while GM 2294 has an enzyme wit[r] ...
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A role for adenosine deaminase in human monocyte maturation
... of adenosine deaminase (ADA) activity in some patients with severe combined immunodeficiency suggests a possible relationship between the activity of ADA and the aberration of the immune ...
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Molecular pathogenesis of emphysema
... Interestingly, adenosine deaminase– deficient mouse lungs show inflammation and alveolar space enlargement 88, adenosine causes endothelial cell apoptosis 89, and indeed the authors coul[r] ...
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