adenosine receptors
Squalene-Adenosine Nanoparticles: Ligands of Adenosine Receptors or Adenosine Prodrug?
... Adenosine Receptors Activation. Thus, adenosine re- ceptor activation was evaluated by measuring the levels of intracellular ...Indeed, adenosine receptors are GPCRs known to activate ...
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Adenosine receptors mediate synergistic stimulation of glucose uptake and transport by insulin and by contractions in rat skeletal muscle
... Thus, adenosine receptor antagonism inhibited glucose uptake during simultaneous exposure to insulin and contractions ...A1 receptors to regulate insulin- mediated glucose transport in contracting skeletal ...
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Effect of agonists of adenosine receptors on inflammatory markers in human Muller cells
... adenosine receptors. Recent studies have shown that inflammation plays a major role in the pathogenesis of diabetic retinopathy 29,30 . Several inflammatory markers have been reported which might be ...
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Inosine binds to A3 adenosine receptors and stimulates mast cell degranulation
... results shown in Figs. 3 and 5 indicate that this relatively low potency for BW-A1433 appears to be shared by the guinea pig and the hamster. Although I-ABOPX is somewhat more po- tent than BW-A1433, the latter compound ...
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The gene expression of adenosine receptors in the processes of contrast induced nephropathy in mouse kidney
... Since adenosine receptor expres- sion is changed during ischemic, hypoxic, and inflamma- tion conditions [8-13], the pre-existing kidney diseases may be also required in the development of ...
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Quantitative prediction of selectivity between the A1 and A2A adenosine receptors
... two-step model, which is generally applied in selectivity modeling, selectivity predictions are derived indirectly by calculation of the difference between bioactivity pre- dictions that resulted from two separate ...
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Kinetic Aspects of the Interaction between Ligand and G Protein-Coupled Receptor: The Case of the Adenosine Receptors
... An exploration of ligand binding kinetics at different targets will also help in selectivity profiling. This is complementary to the classical equilibrium selectivity profiling, i.e., determining the affinity of lead ...
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Adenosine Receptors Machinery and Purinergic Receptors in Rat Primary Skeletal Muscle Cells
... is adenosine receptors, which are divided into A 1 , A 2A , A 2B and A 3 adenosine receptors based on pharmacology and coupling to cAMP ...of receptors is P2Y receptors, which ...
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Critical Role of Hypoxia and A2A Adenosine Receptors in Liver Tissue-Protecting Physiological Anti-Inflammatory Pathway
... extracellular adenosine- mediated immunosuppression ...extracellular adenosine levels in the inflamed area was sufficiently high to trigger signaling by A2A and/or A2B adenosine receptors ...
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Bench to bedside review: Adenosine receptors – promising targets in acute lung injury?
... nucleoside adenosine has been demonstrated to regulate both endothelial barrier integrity and polymorphonuclear cell trafficking in the ...lung. Adenosine exerts its effects through four G-protein- coupled ...
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Interactions between striatal dopamine and adenosine receptors: effects of aminophylline on a pharmacological model of parkinson's disease
... The most common hypokinetic motor disorder of NB is Parkinson's disease, characterized by (1) muscle stiffness that is present in all muscle groups, both flexors and extensors, which is usually accompanied by sudden ...
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The Mediating Role of A2A Adenosine Receptors in the Mitochondrial Pathway of Apoptotic Hippocampal Cell Death, Following the Administration of MDMA in Rat
... Despite the persistent effects of MDMA on 5-HT axon terminals, there is evidence that MDMA produces neuronal degeneration within the hippocampus (Kermanian, et al., 2012; Warren, et al., 2007). The mechanism of MDMA- ...
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A1 adenosine receptors inhibit chloride transport in the shark rectal gland Dissociation of inhibition and cyclic AMP
... phenylisopropyl-adenosine (R-PIA) also completely inhibited forskolin stimulated chloride secretion. The "S" stereoisomer of PIA (S-PIA) was a less potent inhibitor of forskolin stimulated chloride ...
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Renal protection from ischemia mediated by A2A adenosine receptors on bone marrow–derived cells
... 24. Rookmaaker, M.B., et al. 2002. Bone-marrow-derived cells contribute to endothelial repair after thrombotic microangiopathy. Blood. 99:1095. 25. Ikpeazu, C., Davidson, M.K., Halteman, D., Browning, P.J., and Brandt, ...
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Original Article Expression of adenosine receptors in muscle tissues from patients with idiopathic inflammatory myopathies
... Abstract: This study aimed to determine the expression pattern of the adenosine receptor (AR) subtypes A 2A , A 2B , and A 3 in human idiopathic inflammatory myopathies (IIMs). A total of 27 patients diagnosed ...
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A1 and A2 adenosine receptors in rabbit cortical collecting tubule cells Modulation of hormone stimulated cAMP
... Adenosine analogs were used to investigate the cellular mechanisms by which adenosine may alter renal tubular function. Cultured rabbit cortical collecting tubule (RCCT) cells, isolated by immunodissection, ...
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Allosteric regulation of adenosine receptors
... coupled receptors (eg p-adrenoceptors and muscarinic receptors) it is commonly found that there is an apparent incomplete receptor-G protein coupling in the presence of agonist: the Hill slopes of ...
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Adenosine and adenosine analogues stimulate adenosine cyclic 3', 5' monophosphate dependent chloride secretion in the mammalian ileum
... Adenosine receptors that modulate adenylate cyclase activity have been identified recently in a number of ...of adenosine on ion transport in rabbit ileum in vitro. Adenosine and some of its ...
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Direct preconditioning of cultured chick ventricular myocytes Novel functions of cardiac adenosine A2a and A3 receptors
... of adenosine receptors in mediating ...of adenosine in mediating the precondi- tioning effect, the ventricular cells, instead of being exposed to the brief hypoxia, were incubated with ...
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Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization
... surface adenosine receptors by endog- enous adenosine requires it to be available at the extracellular surface of ...Extracellular adenosine can rise as a conse- quence of several pathways ...
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