Adverse Drug Event Report Database
Signals of gastroesophageal reflux disease caused by incretin-based drugs: a disproportionality analysis using the Japanese adverse drug event report database
... Background: Incretin-based drugs are important in the treatment of type 2 diabetes. However, among the incretin- based drugs, glucagon-like peptide-1 receptor agonists (GLP-1-RAs) have been reported to cause ...
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Analyses of non-benzodiazepine-induced adverse events and prognosis in elderly patients based on the Japanese adverse drug event report database
... AE: Adverse event; BCPNN: Bayesian confidence propagation neural network; BZ: Benzodiazepine; CI: Confidence interval; CNS: Central nervous system; GABA: Gamma-aminobutyric acid; GPS: Gamma-Poisson ...
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Evaluation of medication-related osteonecrosis of the jaw using the Japanese Adverse Drug Event Report database
... and adverse drug events, which we selected as “MRONJ” in the Preferred Term coded in ...specific adverse event caused by a particular drug divided by the rate of the same adverse ...
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Analysis of Stevens-Johnson syndrome and toxic epidermal necrolysis using the Japanese Adverse Drug Event Report database
... In the EuroSCAR-study, Mockenhaupt et al. examined the time course of SJS/TEN onset [6]. From their results of the time latency between the beginning of drug use and the onset of SJS/TEN, the time-to-onset ...
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Dextromethorphan: a case study on addressing abuse of a safe and effective drug
... is adverse events reported to the FDA Adverse Event (AE) Reporting System database ...the drug was the causative ...serious adverse events associated with DXM over the first 3 ...
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Analysis of fall-related adverse events among older adults using the Japanese Adverse Drug Event Report (JADER) database
... potential drug interactions between antidepressants and ...CNS-active drug use and falls among older adults [52–56], which suggests that pharmacodynamic drug interactions ...CNS-active drug ...
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Hyperglycemic adverse events following antipsychotic drug administration in spontaneous adverse event reports
... hyperglycemic adverse events, whereas ari- piprazole (AAP), haloperidol (TAP), and ziprasidone (AAP) had a low association in the FAERS ...previous report [19] and our ...for adverse hyperglycemic ...
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Drug-induced tubulointerstitial nephritis in a retrospective study using spontaneous reporting system database
... Japanese Adverse Drug Event Report (JADER) database, which contains information on the ADRs and patients in Japan since April 1, ...which adverse event reports were ...
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Safety Profile of Levonorgestrel: A Disproportionality Analysis of Food and Drug Administration Adverse Event Reporting System (FAERS) Database
... Post-marketing studies help in determining po- tential safety issues. In this paper, ten novel AEs (Breast enlargement, breast tenderness, dysmenor- rhea, ectopic pregnancy, menorrhagia, menstrua- tion delayed, ...
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Onset Time Profiles for Syncope Associated with α1 Adrenoceptor Blockers in Males: Analysis of a Spontaneous Adverse Drug Event Database
... Japanese Adverse Drug Event Report (JADER) database for a period from April 2004 until November 2016 and calculated reporting odds ratios (RORs) for eight α 1Bs available on the ...
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Effect of database profile variation on drug safety assessment: an analysis of spontaneous adverse event reports of Japanese cases
... may report the same case while identifying different medicines as the primary suspected ...case report number, other sender’s case report number, or other case identifiers in previous trans- ...case ...
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Mortality and oral anticoagulants in the Food and Drug Administration Adverse Event Reporting System
... FAERS database and conducted analyses of deaths records. We performed drug mapping and created a list of synonyms for five anti- ...avoided event mapping since we were looking for the single outcome ...
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Fatal Hydrocodone Overdose in a Child: Pharmacogenetics and Drug Interactions
... first report, to our knowledge, to suggest that pharmacogenetics and drug-drug interactions can contribute to the lethal hydrocodone concentrations observed in these ...
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Pattern of Drug Use and their Safety Profile in the Management of Chronic Obstructive Pulmonary Disease in a Tertiary Care Hospital
... 86 The choice of inhaler device for patients with COPD depends upon multiple attributes. Efficient delivery of inhaled medication is essential for the success of COPD therapy. The inhaler device may contribute to optimal ...
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The Emergency Division as a strategic center for pharmacovigilance activities. The role of hospital pharmacist experience at the Hospital *Gaetano Rummo* of Benevento
... Adverse drug reactions don't only affect the health of population but also have an high econo- mic costs. Investigations on this subject have been conducted only in recent times probably because it is ...
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Pharmacovigilance in juvenile idiopathic arthritis patients treated with biologic or synthetic drugs: combined data of more than 15,000 patients from Pharmachild and national registries
... the database technical characteristic (for example, Sql server version 2005 and Access 2010) and the field coding (for example, gender, int, 1 = male; 2 = ...
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Representing Clinical Notes for Adverse Drug Event Detection
... An advantage of using the terms representation is that, in comparison to the other representations – in particular the distributed ones – it lends itself to some degree of interpretability. While random forest belongs to ...
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<p>Opioids and frequency counts in the US Food and Drug Administration Adverse Event Reporting System (FAERS) database: a quantitative view of the epidemic</p>
... FAERS database were associated with ADEs, including death, and 3 drugs (oxycodone, hydrocodone, fentanyl) accounted for more than half of the ...to drug count was heroin ...
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Extracting Adverse Drug Event Information with Minimal Engineering
... nearby drug argument and some trigger words to be anno- ...train Drug- ADE and Drug-Reason relation classifiers, where the candidates for ADE and Reason arguments are all signs/symptoms and ...
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<p>Comparison of Adverse Event Profiles of Tumor Necrosis Factor-Alfa Inhibitors: Analysis of a Spontaneous Reporting Database</p>
... unexpected adverse events could occur because patients have various backgrounds and etiologies, unlike in clinical trials, where enrollment criteria are ...unexpected adverse drug effects can emerge, ...
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