Akt/ GSK-3β
Original Article The role of the PI3K/Akt/GSK-3β pathway in postoperative cognitive dysfunction in elderly rats
... PI3K, AKT, and GSK-3β were decreased, whereas Cyto C and caspase-9 were increased in rat hippocampus of the anesthesia group and the splenectomy group ...and GSK-3β, as well as ...
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Original Article miR-124a targets PDK1/Akt/GSK-3β signaling in pancreatic β-Cells and regulates biological responses to glucose
... phorylates Akt kinase on Ser-3473, which becomes activated and phosphorylates a se- ries of substrates, including transcription fac- tor ...of Akt. Immunoblot analysis show- ed that in response to insulin, ...
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Original Article 17β-Estradiol protects the liver against warm ischemia-reperfusion injury through the Akt/GSK-3β pathway
... 38]. GSK-3β is a downstream signaling molecule of ...more, GSK-3β is a continuously activated pro- tein kinase which can promote cell ...Once Akt is activated, it will cause ...
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Resveratrol modulates the Akt/GSK-3β signaling pathway in a middle cerebral artery occlusion animal model
... of Akt is ...of GSK-3β by resveratrol treatment in MCAO-induced cerebral ...regulates Akt and its downstream target, ...phospho- GSK-3β. GSK-3β induces cell death ...
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Epigallocatechin-3-gallate-mediated cardioprotection by Akt/GSK-3β/caveolin signalling in H9c2 rat cardiomyoblasts
... The link between Cav-1 activation and GSK-3β signalling pathway could be achieved by Akt activation (Figure 7a). Thus, during oxidative stress by myocardial ischemia assault Cavs can modulate ...
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Original Article Puerarin protects against myocardial ischemia/reperfusion injury via the AMPK/Akt/GSK-3β/Nrf2 signaling pathway
... that GSK-3β phosphorylation was induced by Puerarin treat- ...kinase Akt is activated downstream of phosphati- dylinositol 3-kinase ...decreased Akt phosphorylation and Puerarin pretreatment ...
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Original Article Celastrol inhibits colon cancer cell proliferation by downregulating miR-21 and PI3K/AKT/GSK-3β pathway
... Abstract: Celastrol is a traditional Chinese medicine, that is derived from Tripterygium wilfordii. It has been pro- posed to offer anti-tumor potential. MicroRNAs also play important roles in tumorigenesis. However, the ...
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ST6Gal-I overexpression facilitates prostate cancer progression via the PI3K/Akt/GSK-3β/β-catenin signaling pathway
... expression of the PI3K/Akt/GSK-3β/β-catenin signaling pathway and related metastasis regulators in ST6Gal-I- knockdown and control PCa cells. The results showed that ST6Gal-I knockdown decreased the ...
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Original Article Paeonol induces apoptosis of ovarian cancer cells through the AKT/GSK-3β signaling pathway
... Abstract: Cisplatin-centered systemic chemotherapy is generally considered the essential method of ovarian cancer therapy. However, due to the high proportion of chemotherapy resistance and the associated side effects of ...
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Tetramethylpyrazine exerts a protective effect against injury from acute myocardial ischemia by regulating the PI3K/Akt/GSK-3β signaling pathway
... Total proteins were extracted from myocardial tissues using ice-cold RIPA lysis buffer. Dissolved proteins were collected and the debris was removed via centrifugation at 12,000 rpm for 5 min at 4 °C. The concentration ...
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Gas6/Axl Axis Contributes to Chemoresistance and Metastasis in Breast Cancer through Akt/GSK-3β/β-catenin Signaling
... of Akt/GSK3β/β-catenin signaling was identified following stimulation with Gas6, the main ligand of ...of Akt/GSK3β/β-catenin pathway, which suppressed the activity of GSK-3β and stabilized ...
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Proteomic Identification of 14-3-3ζ as an Adapter for IGF-1 and Akt/GSK-3β Signaling and Survival of Renal Mesangial Cells
... of GSK-3β for several therapeutic uses, including the treatment of neurodegenerative diseases, type 2 diabetes, bipolar disorders, and chronic inflammatory ...of GSK-3β expression or blocking ...
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CD36 mediates palmitate acid-induced metastasis of gastric cancer via AKT/GSK-3β/β-catenin pathway
... of GSK-3β which inhibited degradation of β-catenin [25–27, ...of AKT and GSK-3β which consequently decreased the nuclear localization of β-catenin and therefore sup- pressed the ...
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miR-96 exerts carcinogenic effect by activating AKT/GSK-3β/β-catenin signaling pathway through targeting inhibition of FOXO1 in hepatocellular carcinoma
... activated AKT/GSK-3β/β-catenin signaling pathway by inhibition of ...affect AKT, GSK-3β and β-catenin protein ...of AKT/GSK-3β/β- catenin signaling pathway ...
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Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease
... PI3K/ AKT /GSK-3 β pathway Several medicinal herbs and foods may regulate the activity of the PI3K/ AKT /GSK-3β ...PI3K/ AKT /GSK-3β pathway ...PI3K/ AKT ...
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Targeting Akt by SC66 triggers GSK-3β mediated apoptosis in colon cancer therapy
... the AKT important therapeutic target. AKT, also known as protein kinase B (PKB), is a serine/threonine kinase that mediates cell proliferation, protein synthesis, transcription, and apoptosis ...stimuli, ...
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Cryptotanshinone Induces Cell Cycle Arrest and Apoptosis of NSCLC Cells through the PI3K/Akt/GSK-3β Pathway
... CTT affected the expression levels of proteins related to cell cycle regulatory in A549 and H460 cells.. 116.[r] ...
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Cardioprotective effects of tanshinone IIA pretreatment via kinin B2 receptor-Akt-GSK-3β dependent pathway in experimental diabetic cardiomyopathy
... The present study only focused on the kinin B2 recep- tor-Akt-GSK-3 b signaling pathway. Some other path- ways may also participated in the pathogenesis of diabetic cardiomyopathy such as MAPK related path- ...
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Distinct biological effects of low-dose radiation on normal and cancerous human lung cells are mediated by ATM signaling
... the AKT/glycogen synthase kinase (GSK)-3β signaling pathway, which stimulated HBE cell ...ATM/AKT/ GSK-3β signaling also increased nuclear accumulation of nuclear factor ...
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Original Article Peony reverses tau phosphorylation level in mouse depression model via BDNF-Akt-GSK3 beta pathway
... Peony is a tranditional Chinese herbal formalue for the treatment of depression-like symptoms via inhibiting activity of HPA axis [18]. It has been reported that a glycoside-rich extract of peony could reverse the ...
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