Akt signaling pathway
Apatinib potentiates irradiation effect via suppressing PI3K/AKT signaling pathway in hepatocellular carcinoma
... 4a, pathway enrichment analysis revealed that PI3K-AKT sig- naling pathway was significantly affected in both SMMC- 7721 and MHCC-97H cell ...PI3K/ AKT cascade is up-regulated by radiation ...
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miR-93 Promotes Cell Proliferation in Gliomas through Activation of PI3K/Akt Signaling Pathway
... PI3K/Akt signaling pathway is essential to the development and/or progression of most cancer types and associated with nearly all aspects of the malignant phenotype of cancer, such as uncontrolled ...
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Down-regulation of the PI3K/Akt signaling pathway and induction of apoptosis in CA46 Burkitt lymphoma cells by baicalin
... growth signaling pathway is comprised of a family of intracellular protein kinases, each of which is regulated by phosphorylation and possesses unique substrate ...Activated Akt, the primary medi- ...
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Original Article Apoptosis prediction via inhibition of AKT signaling pathway by neogrifolin
... inhibited AKT phosphorylation at these two sites. As the downstream targets of Akt, GSK3 and FKHR family of transcription fac- tors have been reported to be involved the reg- ulation of the cells ...
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Formononetin induces vasorelaxation in rat thoracic aorta via regulation of the PI3K/PTEN/Akt signaling pathway
... In the present study, we evaluated the potential role of FMN in ameliorating the KCl-induced vasoconstriction of rat arte- rial rings. Bioinformatics analyses revealed that the PI3K/ PTEN/Akt pathway was ...
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Effect of PI3K/Akt Signaling Pathway on PRAS40Thr246 Phosphorylation in Gastric Cancer Cells
... and AKT inhibitor, the level of p-PI3K and p- ATK in gastric cancer cells of the LY294002 group was lower than that in untreated gastric cancer cells; p-AKT level in MK-2206 group was deceased, and the ...
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Original Article TRAF2 activates the Akt signaling pathway via TRAF4-mediated ubiquitination of Akt and promotes migration and invasion of breast cancer cells
... and Akt levels correlated positively in breast cancer ...and Akt in breast can- cer cell lines were significantly higher than in normal breast cell ...the Akt signal- ing pathway in breast ...
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TRIM27 promotes the development of esophagus cancer via regulating PTEN/AKT signaling pathway
... Methods: In the present study, RNA interference (RNAi) and lentiviral vector were used to knockdown and over‑ expression of TRIM27 in ESCC cells respectively. qRT‑PCR and western blot were used to examine the expression ...
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LncRNA AK023391 promotes tumorigenesis and invasion of gastric cancer through activation of the PI3K/Akt signaling pathway
... NF–κB signaling pathways are constitutively activated in various cancers, including breast cancer, prostate cancer, GC, and pancreatic can- cer [35–39], and result in cancer initiation and progres- ...
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Original Article Dipalmitoylphosphatidic acid reduces osteosarcoma growth by activation of AKT signaling pathway
... 18]. Akt is an important gene and plays a key role in the regulation of cell ...Additionally, Akt signaling pathway significantly affects cell adhesion in the extracellular ...the Akt ...
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Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3 L1 cells
... ing pathway in preventing obesity; hormones and growth factors that are specific to adipogenesis act via their receptors to transduce external differentiation sig- nals through a cascade of intracellular events in ...
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SKA3 promotes cell proliferation and migration in cervical cancer by activating the PI3K/Akt signaling pathway
... Some signaling pathways have been found to have important functions in the occurrence and progression of CC, such as the Notch1 ligand, Wnt/beta-catenin, p53, p38 MAPK, and PI3K/Akt/mTOR signaling ...
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Zileuton suppresses cholangiocarcinoma cell proliferation and migration through inhibition of the Akt signaling pathway
... the Akt signaling pathway was inhibited in zileuton-treated KKU-023 ...the Akt signaling pathway was also observed in zileuton-treated KKU-100 cells (data not ...
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Silencing of Synuclein-γ inhibits human cervical cancer through the AKT signaling pathway
... In this study, we transfected cancer cells with a small interfering (si)RNA targeting the SNCG gene, and that efficiently inhibited SNCG expression at the messenger (m) RNA and protein expression level in cervical cancer ...
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Study of Celastrol on Akt Signaling Pathway and Its Roles in the Apoptosis of K562 Cells
... and Akt signaling pathway related proteins were determined by western blot before and after celastrol treatment, and further the effect of AKT signaling pathway on ...
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Original Article Osthenol inhibits the viability of HCT116 cells through suppressing PI3K/AKT signaling pathway
... Abstract: Colon cancer is one of the leading causes of cancer related deaths. The natural products show a great po- tential for anti-cancer use. The objective of the present study to explore the anti-tumor ability of ...
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Original Article Orientin prevents myocardial remodeling after MI through the PI3K/Akt signaling pathway
... Abstract: In the current study, the protective role of orientin in myocardial infarction (MI) and its underlying mecha- nism was explored. Male C57BL/6J mice were treated with anterior wall standard MI surgery and ...
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The natural compound sulforaphene, as a novel anticancer reagent, targeting PI3K-AKT signaling pathway in lung cancer
... PI3K-AKT signaling pathway [26, 30]. In this pathway, AKT is a key regulator of cell survival and apoptosis [26, ...30]. AKT is activated by phospholipid binding and activation ...
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PI3K/Akt signaling pathway is essential for de novo hair follicle regeneration
... PI3K/Akt signaling pathway ranked top in Epi-SCs ...signal pathway in de novo hair follicle regeneration, we performed targeted inhibition of the pathway with specific ...(an Akt ...
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Pharmacological Manipulation of the Akt Signaling Pathway Regulates Myxoma Virus Replication and Tropism in Human Cancer Cells
... signaling pathway and provide novel mechanisms for selec- tively manipulating the Akt network ...of Akt affects MYXV replication in human cancer cells, a collection of small molecular ...
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