allergic airway disease
Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner
... 1.25 μl 10 μM of each primer, 0.25 μl DNA polymerase (Hotstart Phusion 540 L, 1 unit/μl Finnzymes) and 3.5 μl template. The PCR program started with 98 °C (2 min), followed by 35 cycles of denaturation at 98 °C (5 s), ...
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In utero supplementation with methyl donors enhances allergic airway disease in mice
... severe allergic airway disease (lavage eosinophils > 75%) exposed in utero to an HMD and F1 mice with minimal allergic airway disease (lavage eosinophils < 25%) exposed in ...
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Allergic Airway Disease Prevents Lethal Synergy of Influenza A Virus Streptococcus pneumoniae Coinfection
... Allergic airway disease confers protection against postinfluenza secondary bacterial infection. To investigate the impact of AAD on viral-bacterial coinfection, we developed a triple-challenge mouse ...
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Mechanistic insight into the impact of nanomaterials on asthma and allergic airway disease
... that airway epithelial signals initiated by inflammasome activation in- duce fibroblast proliferation and pro-fibrotic gene expres- sion ...induced airway pro- fibrotic exacerbation in mice ...pre-existing ...
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Engineered silica nanoparticles act as adjuvants to enhance allergic airway disease in mice
... In our study, SNP exposure alone, without the antigen, caused a dose-dependent pro-inflammatory response in non-allergic animals as indicated by a modest increase in BALF neutrophils and elevations of ...
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Prolonged ozone exposure in an allergic airway disease model: Adaptation of airway responsiveness and airway remodeling
... of airway remodeling in the lungs of ozone-exposed mice was assessed by histological exami- nation of toluidine blue-stained sections of lung ...the airway epithelium of mice after 4, 8, and 12 weeks of ...
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Identification of microRNAs associated with allergic airway disease using a genetically diverse mouse population
... For the preCC mice, the same RNA isolation protocol was used. We then used Exiqon locked nucleic acid (LNA)- based qRT-PCR assays for each of the 38 miRNAs, except miR-805 (because an assay was not available from ...
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TNF is required for TLR ligand–mediated but not protease mediated allergic airway inflammation
... TNF-dependent allergic airway disease were differentially expressed in WT and TNFR1/2-DKO ...with allergic pulmonary inflammation (reviewed in ...
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PubMedCentral-PMC5669552.pdf
... mediated airway inflammation, mucus production, and ...promote allergic sensitization to OVA when the 2 proteins are coadministered to the airways, and upon OVA challenge these mice develop aller- gic ...
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Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresponsiveness by inhibiting UPR transducers
... The 5 newly tested CBAs and 1 UBA — TCCA, βM, GβM, AβM, and GnβM — were originally dis- solved in DMSO and then further diluted in PBS before instillation, unlike TUDCA, which easily dis- solved in PBS alone. We ...
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Determining the role of ONZIN in immunity
... the allergic airway ...Induced allergic airway studies with IL-5 deficient mice show that lack of this interleukin results in an elimination of airway hyperreactivity and lung ...to ...
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Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation
... of allergic airway inflammation have not yet been ...in allergic airway ...of allergic airway disease, it was found that the increased levels of hypoxia-inducible factor ...
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Prenatal maternal diet affects asthma risk in offspring
... of allergic airway disease in offspring in mice and show that these effects involve epigenetic regulation (see the related article beginning on page ...greater airway aller- gic inflammation ...
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Impact of Aspergillus fumigatus in allergic airway diseases
... the airway cells and other cells such as mast cells, eosinophils, neutro- phils, macrophages, and lymphocytes ...in allergic airway disease owing to its increased expres- sion on the airways ...
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Co-exposure to zymosan A and heat-inactivated Asian sand dust exacerbates ovalbumin-induced murine lung eosinophilia
... In a recent paper, we reported that ASD induces Toll- like receptor (TLR)2 and TLR4 signals to trigger T helper 2 (Th2)-dominant lung allergic inflammation via a mye- loid differentiation factor 88 ...
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Mucosal exposure to cockroach extract induces allergic sensitization and allergic airway inflammation
... Mice sensitized and challenged with CE using the short term protocol developed AHR (Figure 1B) and increased numbers of inflammatory cells (Figure 1C), primarily eosinophils (Figure 1D), in the airways, compared to mice ...
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Interleukin-32: its role in asthma and potential as a therapeutic agent
... AHR: Airway hyper-responsiveness; AML: Acute myeloid leukemia; AR: Allergic rhinitis; BALF: Bronchoalveolar lavage fluid; BD: Behçet ’ s disease; CCL: CC chemokine ligand; CD: Crohn ’ s ...
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Differential effects of simvastatin on IL-13-induced cytokine gene expression in primary mouse tracheal epithelial cells
... responses, and monocyte, basophil, and eosinophil re- cruitment. Pertinent to our findings, there is emerging clinical evidence that simvastatin can reduce sputum eo- sinophil counts. A recent clinical study in ...
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A pathophysiological role of PDE3 in allergic airway inflammation
... PDE3 inhibition and the expression of CD11b. Given the fast antiallergic response, we investigated whether PDE3 effects on integrin might be associated in allergic airway inflammation. Mouse and human ...
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Involvements of p38 MAPK and oxidative stress in the ozone-induced enhancement of AHR and pulmonary inflammation in an allergic asthma model
... including airway hyperresponsiveness (AHR), airway resistance (Raw), lung compliance (CL), inflammation in the airway lumen and lung parenchyma, the phosphorylation of p38 MAPK and heat shock protein ...
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