alpha interferon (generic)
The use of alpha interferon in the management of chronic myeloid leukaemia
... of alpha inteferon, whilst the standard chemotherapy costs are very small at between £100 and £200 and have been ignored for this ...of alpha interferon would be £6,666; one Trust has reported actual ...
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Alpha Interferon and Not Gamma Interferon Inhibits Salmonid Alphavirus Subtype 3 Replication In Vitro
... the alpha interferon (IFN- ␣ )-induced antiviral responses during virus infection in vivo or in vitro in ...the alpha subunit of eukaryotic initiation factor 2 (eIF2 ␣ ) is phosphorylated concomitant ...
10
Inhibition of Alpha Interferon Signaling by Hepatitis B Virus
... Alpha interferon (IFN- ␣ ) and pegylated IFN- ␣ (pegIFN- ␣ ) are used for the treatment of chronic hepatitis B ...to interferon-stimulated response elements (via electrophoretic mobility shift ...
7
Monitoring the Antiviral Effect of Alpha Interferon on Individual Cells
... An infectious hepatitis C virus (HCV) cDNA clone (JFH1) was generated recently. However, quantitative analysis of HCV infection and observation of infected cells have proved to be difficult because the yield of HCV in ...
7
Natural Alpha Interferon-Producing Cells Respond to Human Immunodeficiency Virus Type 1 with Alpha Interferon Production and Maturation into Dendritic Cells
... We substantiated that IPCs expressing the major HIV-1 coreceptors, CXCR4 and CCR5, are susceptible to infection of both T-cell-line-tropic NL4-3 and macrophage-tropic JR-CSF HIV-1 by qua[r] ...
8
Interferon-Inducible CD169/Siglec1 Attenuates Anti-HIV-1 Effects of Alpha Interferon
... I nnate immune responses play a crucial role in combating invading pathogens by sensing pathogen-associated molecular patterns, initiating signaling cascades culmi- nating in secretion of numerous proinflammatory ...
20
Analytical Performance Characteristics and Clinical Utility of a Novel Assay for Total Hepatitis C Virus Core Antigen Quantification
... Among the 38 patients undergoing antiviral combination therapy who had been included in this study, 29 were infected with isolates belonging to HCV genotype 1 or 4 and 9 harbored type 2 or 3 variants. Sixteen individuals ...
8
Aqueous humour protein imbalances in primary open angle glaucoma and their effects on trabecular meshwork cell function
... Interferon alpha Interferon gamma Intraocular pressure Induced pluripotent stem cells Juxtacanalicular tissue Kilodalton Leukemia inhibitory factor Limb development membrane protein 1 li[r] ...
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Tumor necrosis factor alpha negatively regulates hepatitis B virus gene expression in transgenic mice.
... These classes of inflammatory cells produce an assortment of cytokines, such as tumor necrosis factor alpha TNF-a, alpha interferon IFN-ot, gamma interferon IFN-y, interleukin-1 alpha IL[r] ...
6
Human immune responses to Plasmodium falciparum infection: molecular evidence for a suboptimal THαβ and TH17 bias over ideal and effective traditional TH1 immune response
... γ interferon-related genes, as well as genes of IL-15, CD36, chemokines (CXCL10, CCL2, S100A8/9, CXCL9, and CXCL11), TRAIL and IgG Fc ...γ interferon-related genes, IL-8, IL-1b IL-10 downstream genes, ...
19
Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon
... the alpha/beta receptor (1, 6, 11, 28, 29, 33) and, in human fibrosarcoma cells at least, for a set of genes (including that encoding the double-stranded RNA-activated protein kinase, whose antiviral activity has ...
6
Interferon-alpha is a predisposing risk factor for carbamazepine-induced hyponatremia: A case of syndrome of inappropriate antidiuresis caused by interferon-alpha therapy
... that interferon therapy may have reinforced a direct or indirect pharmacological effect of other drugs on the renal ...Also, interferon therapy alone has not been demonstrated to cause ...and ...
6
Influence of insulin resistance on the development of hepatocellular carcinoma after antiviral treatment for non-cirrhotic patients with chronic hepatitis C
... HCV: Hepatitis C virus; HCC: Hepatocellular carcinoma; PEG-IFN α : Pegylated interferon-alpha; SVR: Sustained virological response; AFP: Alpha-fetoprotein; HOMA-IR: Homeostasis model ass[r] ...
10
Combining surgery and immunotherapy: turning an immunosuppressive effect into a therapeutic opportunity
... GM-CSF: Granulocyte macrophage colony stimulating factor; HSV: Herpes Simplex Virus; ICOS: Inducible T cell costimulator; IFN- α : Interferon alpha; IFN- γ : Interferon gamma; LPS/PHA: L[r] ...
11
Changes in peripheral blood lymphocytes in polycythemia vera and essential thrombocythemia patients treated with pegylated-interferon alpha and correlation with JAK2 V617F allelic burden
... high‑dose interferon Alfa‑2b versus cisplatin, vinblastine, and dacarbazine, plus interleukin‑2 and interferon in patients with high‑risk melanoma—an intergroup study of cancer and leukemia Group B, ...
9
Interaction of interferon alpha therapy with thyroid function tests in the management of hepatitis C: a case report
... inflammatory non-autoimmune thyroid dysfunction is clinically characterized by three phases, that is sudden onset of hyperthyroidism, followed by a hypothyroid state and eventually resolution and normalization of thy- ...
5
RIG-I Activation by a Designer Short RNA Ligand Protects Human Immune Cells against Dengue Virus Infection without Causing Cytotoxicity
... Transfection of immRNA in human cell lines inhibits DENV-2 infection. The minimal length of the RIG-I-activating hairpin RNA is a 10-bp stem of a hairpin RNA, as shown previously (21). Based on that work, various ...
18
Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles
... In this larger clinical cohort, we corroborated our pre- vious findings of a positive association between elevated type I interferon and the RNA-associated autoantibodies anti-Ro, anti-La, anti-Sm and anti-RNP ...
12
INTERFERONE INDUCED THYROID DISORDERS IN HCV (HEPATITIS C VIRUS) PATIENTS TREATED WITH INTERFERONE: A REVIEW
... Infarct HCV itself associated with autoimmune disease [12]. About 20% of chronic HCV patient are having circulating thyroid antibody even before starting the interferon therapy. One prospective study was ...
5
Clinical implications of immunecell infiltration in vulvar intraepithelial neoplasia
... Initial infection by HPV causes a cascade of viral gene expression, replication of the viral genome and enhanced cell proliferation.[26] One of the major sensors of DNA viruses is TLR9. Expression of TLR9 is either ...
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