Alpinia galangal

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Evaluation of Anti-Ulcer and Anti-Inflammatory Activity of  Ethanolic Extract of Solanum Pubescens Willd Leaves on  Experimental Animals.

Evaluation of Anti-Ulcer and Anti-Inflammatory Activity of Ethanolic Extract of Solanum Pubescens Willd Leaves on Experimental Animals.

List of Anti-ulcer plants Plant Family Plant part used Alpinia allughas Zingiberaceae Rhizome Alpinia galangal Zingiberaceae Rhizome Alpinia calcarata Zingiberaceae Rhizome Glycyrrhiza g[r]

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IN VITRO COMPARATIVE ANTICANCER ACTIVITY STUDY OF METHANOLIC EXTRACT OF TRADITIONALLY USED MEDICINAL PLANT OF MIZORAM

IN VITRO COMPARATIVE ANTICANCER ACTIVITY STUDY OF METHANOLIC EXTRACT OF TRADITIONALLY USED MEDICINAL PLANT OF MIZORAM

Regional Institute of Paramedical and Nursing Sciences, Zemabawk, Aizwal - 796017, Mizoram, India. ABSTRACT: Objective: The present study explores the anticancer potentially of plant sample based on the evidence from the ethnomedicinal practice of the plant. The main objective was to find out the in-vitro comparative anticancer activity of the various methanolic extract. Method: Plants samples such as Mikania micrantha, Allium hookeri, Eryngium foetidium, and Alpinea galanga were collected, identified, and authenticated. By using Trypan blue test Human cervical cancer (Hela), cells were counted. The Human cervical cancer (Hela) cells were treated with methanolic extract of Mikania micrantha, Allium hookeri, Eryngium foetidium, and Alpinia galangal and 20 µL of MTT (5 mg/mL) solution was added to cells per well, and the plate was moved to a CO 2 incubator (3-4 h incubation). Measurement
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HIGH FREQUENCY SHOOT TIP MULTIPLICATION AND EXVITRO ROOTING OF CENTELLA ASIATICA (L ) URB    A INDUSTRIAL MEDICINAL HERB

HIGH FREQUENCY SHOOT TIP MULTIPLICATION AND EXVITRO ROOTING OF CENTELLA ASIATICA (L ) URB A INDUSTRIAL MEDICINAL HERB

bud differentiation in Plambago indica. [27] Thus, the role of gibberellic acid with respect to shoot bud induction in medicinal plant species remains controversial. Synergistic effect of a range of growth regulators in combination with BAP on promotion of shoot multiplication of C. asiatica was previously documented. [28] Various successful combinations have been reported such as BAP+IAA for Curculico orchioides [29] , Alpinia galangal [30] , BAP plus NAA for Gomphrena officinalis [31] and Rauwolfia serpentine [32] , BAP plus GA3 for Tridax procumbens [19] , BAP plus 2,4-D for Withania sominifera [33] , BAP plus IBA for Rheum emodi [34] and Gardenia jasminoides [35] , and BAP plus KN for Feronia limonia [36] , Kaempferia galangal. [37]
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Antiproliferative activity and induction of apoptotic by ethanolic extract of Alpinia galanga rhizhome in human breast carcinoma cell line

Antiproliferative activity and induction of apoptotic by ethanolic extract of Alpinia galanga rhizhome in human breast carcinoma cell line

mutagenesis and carcinogenesis. All cells are exposed to oxidative stress, and thus oxidation and free radicals may be important in carcinogenesis at multiple tumor sites [12]. The antioxidant activity may be the result of the spe- cific scavenging of reactive free radicals, scavenging of oxygen containing compounds such as hydrogen peroxide and chelating metals [13,14]. Phytochemical and dietary antioxidants may decrease the risk of much chronic dis- ease such as cancer. Antioxidants scavenge free radicals, and consequently are a very special group of nutrition supplements [15]. Plants have played an important role as a source of effective anticancer agents, and it is significant that 60% of currently used anticancer agents are derived from natural sources including plants, marine organisms, and microorganisms [16]. Alpina galanga (galangal) is a well-known plant in the Southeast Asia. The rhizomes of Zingiberaceae family are widely used in many ancient countries in traditional medicine which is found to be ef- fective in the treatment of diseases [17]. Their function have been broadly discussed and accepted in many trad- itional recipes. Alpinia galangal has bben studied by vari- ous researchers and a number of active constituents from the plant have been isolated and reported. Phenolic com- pounds such as flavonoids and phenolic acids are found abundantly in this plant [18]. The dominant components isolated from the rhizomes were galangoisoflavonoid [19], β-sitosterol diglucosyl caprate [20], methyleugenol, p-coumaryl diacetate, 1′-acetoxyeugenol acetate, trans-p- acetoxycinnamyl alcohol, trans-3,4-dimethoxycinnamyl al- cohol, p-hydroxybenzaldehyde, p-hydroxycinnamaldehyde, trans-p-coumaryl alcohol, galangin, trans-p-coumaric acid, and galanganol B [21]. The major phytoconstituents which have been isolated from the rhizomes are acetoxychavicol acetate (ACA) and hydroxychavicol acetate (HCA) [22]. Rhizomes are lowest in fat but richest in carbohydrate [23
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GENUS ALPINIA, A POTENTIAL POWERHOUSE OF BIOACTIVE: A REVIEW

GENUS ALPINIA, A POTENTIAL POWERHOUSE OF BIOACTIVE: A REVIEW

Abdullah et al., 2015 reported that essential oil from Alpinia galanga and 1,8-cineol poses antifeedant, repellent and toxicity activity against Asian subterranean termites Coptotermes gestroi and Coptotermes curvignathus. Further, studies have shown that Alpinia galangal can also use to control Plutella xylostella, Callosobruchus chinensis, Sitophilus zeamais, Tribolium castaneum, and two parasitoids 110, 111 . Seed extracts showed mortality against Tyrophagus putrescentiae and Dermatophagoides pteronyssinus due to the effect of acaricides present in Alpinia galangal 112 . 15. As a Natural Dye: Some species in genus Alpinia has been used to extract natural dyes. Wang et al., 2013 reported that natural dyes were extracted from the leaves and stems of Alpinia blepharocalyx K. Schum and the experiment revealed that optimal amount of dye could be
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QUALITATIVE PHYTOCHEMICAL SCREENING TESTS OF ALPINIA GALANGA L

QUALITATIVE PHYTOCHEMICAL SCREENING TESTS OF ALPINIA GALANGA L

particularly with compounds such as sex hormones. The phenolic compounds like flavonoids and tannins are a major group of compounds which are known for primary antioxidants or free radical scavengers. Since these compounds were found in the leaves of Alpinia galangal (L.). Hence it might be answerable for the effective nephroprotective activity.

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Inhibitory Effect on Cell Growth and Cytotoxicity of Kouchner Plant (Alpinia galanga L) Extract on Squamous Cell Carcinoma Cell Line in vitro: A Case–control Study

Inhibitory Effect on Cell Growth and Cytotoxicity of Kouchner Plant (Alpinia galanga L) Extract on Squamous Cell Carcinoma Cell Line in vitro: A Case–control Study

Introduction: Malignancy is the main cause of death in devel- oped countries and the second leading cause of death in devel- oping countries. The aim of the present study was to carry out an investigation of inhibitory and cytotoxic effect of Kouchner (Alpinia galanga L) extract on cell growth with a potential of selective effect on malignant cells of squamous cell carcinoma (SCC) compared with normal cells.

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A Pharmacological Evaluation for the Ethanolic Extract of Alpinia Calcarata Rhizome for it’s Anti - Asthmatic, Antioxidant and Anti - Inflammatory Activities

A Pharmacological Evaluation for the Ethanolic Extract of Alpinia Calcarata Rhizome for it’s Anti - Asthmatic, Antioxidant and Anti - Inflammatory Activities

administration. Leukocytes during asthmatic inflammation release the inflammatory mediators like cytokines, histamine and major basic protein, which promote the ongoing of inflammation. The infiltration of leukocytes potentiates the inflammatory process by the release of reactive oxygen species into the surrounding tissue, resulting in increased oxidative stress and associated with many pathological features of asthma. In this study we observed that leukocyte count was decreased in mice treated with ethanolic extract of plant at doses 100 and 200 mg/kg significantly as compared to control group. Results suggests that the ethanolic extract of the plant Alpinia calcarata rhizomes decreases milk induced leukocytes count by normalizing
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Addition of defatted green-lipped mussel powder and mixed spices to wheat–purple rice flour biscuits: Physicochemical, in vitro digestibility and sensory evaluation

Addition of defatted green-lipped mussel powder and mixed spices to wheat–purple rice flour biscuits: Physicochemical, in vitro digestibility and sensory evaluation

Biscuits were formulated using a 50/50 wheat and purple rice flour mix containing mixed spices, galangal, and defatted green- lipped mussel powder (Perna canaliculus) added in the range of 5–15% of the total biscuit weight. The fortified biscuits had higher protein (26.36%), fiber (52.90%), and ash (6.00%) contents and a lower total fat (5.64%) content compared to the control biscuits. The in vitro starch digestibility and predicted glycemic index (pGI) decreased in the fortified biscuits by 18.95% and 6.18%, respectively, while the in vitro protein digestibility increased by 3.73%, cor- responding to the increased levels of defatted mussel powder present. The spread ratio and hardness of the fortified biscuits also increased significantly. The color val- ues of the fortified biscuits after the incorporation of different levels of defatted mussel powder showed significant changes, with a darkening of the biscuit surface and a lowered browning index compared to the control biscuits. Results of the sen- sory quality evaluation showed that incorporation of defatted mussel powder into the biscuit mix of up to 15% showed no significant differences in liking scores in terms of color, overall appearance; whereas, the flavor and overall acceptability scores were significantly lower than the control biscuits. Overall, defatted mussel powder can be successfully incorporated into biscuit mixes to enrich the protein, fiber, and antioxidant contents of the biscuits.
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Growth and Characterization of Struvite Crystals by Alpinia Calcarata Stem Extract

Growth and Characterization of Struvite Crystals by Alpinia Calcarata Stem Extract

Abstract: To investigate the inhibitory effect of methanol extract of Alpinia calcarata stem on the growth of struvite crystals. Struvite crystals were grown by the single diffusion gel growth technique and the inhibitory effect of methanol extracts of Alpinia calcarata stem on the growth of struvite crystals has been studied. The grown crystals were characterized by Fourier Transform Infrared Spectroscopy (FTIR) methods for further confirmations. With an increase in the concentration of methanol extract of Alpinia calcarata stem, the weight of the formed crystals were gradually reduced from 2.83 g to 0.24 g in struvite crystals, respectively. The crystals are harvested from the struvite were characterized by Fourier Transform Infrared Spectroscopy (FTIR) to confirm the functional groups Results obtained are indicated that Alpinia calcarata stem has the potential to inhibit the formation of struvite crystals. This study confirms that using methanol extract of Alpinia calcarata stem can promote the formation of ammonium magnesium phosphate hexahydrate crystals and reduce the nucleation rate of struvite crystals, a major component of triple phosphate urinary stone.
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Cytotoxic activity of Thai medicinal plants against human cholangiocarcinoma, laryngeal and hepatocarcinoma cells in vitro

Cytotoxic activity of Thai medicinal plants against human cholangiocarcinoma, laryngeal and hepatocarcinoma cells in vitro

cell line CL-6 were investigated. In addition, their com- parative activity against the other two human cancerous cell lines, i.e., Hep-2 (laryngeal carcinoma) and HepG2 (hepatocarcinoma), and one normal cell HRE (human renal epithelial cell) was also examined. These plants have been used by Thai people to treat different illness. The five recipes were used for restorativeness, treatment of fever, cold and cancer (Table 1). The eighteen plants tested were composition of Pra-Sa-Prao-Yhai recipe, and some plants were composition of other recipes (Table 1). The leave, stem, bark and rhizome parts of plants were most often used for these traditional medicines (Table 1). Results from the initial screening showed that the extracts from seven plant species (Atractylodes lancea, Kaempferia galangal, Zingiber officinal, Piper chaba, Mesua ferrea, Ligusticum sinense, Mimusops elengi) and one folklore recipe (Pra-Sa-Prao-Yhai) exhibited promis- ing activity against the cholangiocarcinoma CL-6 cell line with cell survival of less than 50% at the concentration of 50 μ g/ml (Table 2). Among these, six (Atractylodes lan- cea, Kaempferia galangal, Zingiber officinal, Piper chaba, Mesua ferrea, and Pra-Sa-Prao-Yhai recipe) showed potent cytotoxic activity with IC 50 values of less than 50
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Molecular characterisation of alpinia species from western ghats

Molecular characterisation of alpinia species from western ghats

PCR was controlled on 1% agarose gel in 0.5x TBE (10x stock contained 1 M Tris, 0.8 M boric acid, 0.5 M EDTA) stained with EtBr and visualised under UV. The gel image was documented with KODAK Gel Logic 100gel documentation system (Kodak, New Haven, USA) and analysed with UVITEC TM analysis package (Cambridge, UK). Sanger dideoxy technology 14 were used for the sequencing. All sequences of Alpinia species have been deposited in Genbank using the SEQUIN 12.30 (Accession numbers KJ609028.1 to KJ609034.1).

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Evaluation of Antioxidant Activities of Alpinia galanga (L.) Willd

Evaluation of Antioxidant Activities of Alpinia galanga (L.) Willd

Alpinia galanga (L.) Willd. (commonly called greater galanga) is a perennial aromatic rhizomatous herb of Zingiberaceae family which is widely cultivated in South East Asia. The plant is widely used as spices for flavouring food as well as herbal remedy in traditional system of medicine such as Ayurveda, Unani, Chinese and Thai folk medicine 10 . The rhizome has a wide range

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Flavokavain B from the rhizome of alpinia mutica roxb

Flavokavain B from the rhizome of alpinia mutica roxb

The rhizome of Alpinia mutica was collected from Pontian, Johor, Malaysia. A voucher specimen was deposited at the Herbarium of the Departmentof Botany, Universiti Putra Malaysia. The n-hexane crude extract of the rhizome (8.97 g) was subjected to silica-gel chromatography and was eluted out by using a gradient mixture of petroleum ether, ethanol and methanol. Twenty three fractions were collected, which were then separated by TLC to afford eight fractions. The sixth fraction was subjected to silica-gel column chromatography to give the title compound (petroleum ether: ether 4/1)which was recrystallized from petroleum ether/ether to afford faint yellow-orange crystals suitable for data collection.
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Alpinia calcarata: potential source for the fabrication of bioactive silver nanoparticles

Alpinia calcarata: potential source for the fabrication of bioactive silver nanoparticles

In the present study silver nanoparticles fabricated by using leaf extract of Alpinia calcarata. We have also studied the effect of various experimental parameters viz., metal ion concentration, pH and incubation period on nanoparticle biosynthesis. Results of optimization showed that metal ion concentration of 1.5 mM, alkaline pH and incubation period of 12 h were the optimum conditions for metal nanoparticle biosynthesis. Synthesized silver nanoparticles were characterized by UV–Visible spectroscopy, Dynamic light scattering (DLS), Zeta potential analysis, Fourier trans- form infrared spectroscopy (FTIR), Inductively coupled plasma-optical emission spectrometry (ICP-OES), Transmis- sion electron microscopy (TEM) and X-ray diffraction analysis (XRD). The UV–visible spectrum shows a sharp peak at 420 nm which was due to the surface plasmon resonance of the silver nanoparticles. Effect of several phytochemicals present in A. calcarata, on synthesis of silver nanoparticles was studied by Fourier transform infrared spectroscopy. The results indicate that the flavonoids, phytosterol, quinones and phenolic compounds present in the plant extract plays a major role in formation of silver nanoparticles in their respective ions in solution. Results of TEM and XRD analysis showed that synthesized silver nanoparticles were mostly spherical in shape with an average diameter of 27.2 ± 0.2.5 nm and highly crystalline in nature. Moreover the synthesized silver nanoparticles were also evaluated for their potential antibacterial and antioxidant activities. It showed good antibacterial activity as well as antioxidant activity. Thus the obtained result provides a scientific support that leaf extract of A. calcarata can be used efficiently in the production of potential bioactive silver nanoparticles with several pharmaceutical applications.
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In vitro antibacterial, antifungal, antioxidant and antihemolytic activities of Alpinia galanga

In vitro antibacterial, antifungal, antioxidant and antihemolytic activities of Alpinia galanga

All the organic fractions exhibiting high antioxidant potential were further selected for in vitro determination of antioxidant activity on H 2 O 2 induced erythrocyte hemolysis and l[r]

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EVALUATION OF THE ANTI INFLAMMATORY AND ANTIPYRETIC ACTIVITIES OF THE PLANT ALPINIA NIGRA (FAMILY: ZINGIBERACEAE)

EVALUATION OF THE ANTI INFLAMMATORY AND ANTIPYRETIC ACTIVITIES OF THE PLANT ALPINIA NIGRA (FAMILY: ZINGIBERACEAE)

the other hand pyrexia is a common medical sign characterized by an elevation of temperature above the normal range of 36.5–37.5 °C (98–100 °F) due to an increase in the body temperature regulatory set-point. This increase in set-point triggers increased muscle tone and shivering. Drugs that are currently used for the management of inflammation and pyrexia are non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids. All these drugs carry potential toxic effects. One study suggests that risk of gastrointestinal bleeding was significantly associated with acute use of non-steroidal anti-inflammatory drugs (NSAIDs) like regular-dose aspirin, diclofenac, ketorolac, naproxen or nimesulide. Piroxicam increased the risk of bleeding in both acute and chronic therapy. On the contrary many medicines of plant origin had been used since ages without any adverse effects. It is therefore essential that efforts should be made to introduce new medicinal plants to develop more effective and cheaper drugs. A. nigra is an important medicinal plant having application in jaundice [3], fever [4] and constipation [5]. It is also known to be a blood purifier and is also reported to have anti-viral use [4]. The present study was designed to investigate the anti- inflammatory and Antipyretic potential of the crude methanolic extracts of the whole plant Alpinia nigra.
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INFLUENCE OF ALPINIA GALANGA RHIZOMES ON CAFETERIA DIET 
INDUCED OBESITY IN RATS

INFLUENCE OF ALPINIA GALANGA RHIZOMES ON CAFETERIA DIET INDUCED OBESITY IN RATS

The rhizomes of Alpinia galanga were collected from the fields surrounding Belgaum, Karnataka, India during September 2008 and were positively identified by Dr. S.S. Sasalatti, Head, Department of Botany, R.L. Science College, Belgaum, Karnataka, India, where a voucher specimen has been deposited. The rhizomes were air dried, powdered, and then extracted with 70% ethanol by Soxhlet method. The extract was filtered with Whatman No. 1 filter paper and then solvent evaporated at reduced pressure by using Rotavapor apparatus to get a viscous mass, which was then stored at 4°C until used. The % yield of the extract obtained was 4.2%.
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Neuroprotective Functions of Alpinia galanga in Forebrain Ischemia Induced Neuronal Damage and Oxidative Insults in Rat Hippocampus

Neuroprotective Functions of Alpinia galanga in Forebrain Ischemia Induced Neuronal Damage and Oxidative Insults in Rat Hippocampus

The transient forebrain ischemia was induced by bilateral common carotid artery occlusion (BCCAO) followed by reperfusion injury. The rats were randomly divided into four groups (n=12 in each group). Vehicle control rats were administered with 0.5% carboxyl methyl cellulose orally and subjected to sham operated ischemia. BCCAO group administered with 0.5% carboxyl methyl cellulose served as ischemic control. An acute toxicity study performed based on OECD test guidelines has reported that Alpinia galanga has LD 50 >2000 mg/kg body weight and hence 200 and 400mg/kg body weight was chosen as dose for the current study. 36 BCCAO -
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COMPARATIVE PHARMACOGNOSTIC AND PHYTOCHEMICAL INVESTIGATION OF TWO ALPINIA SPECIES FROM ZINGIBERACEAE FAMILY

COMPARATIVE PHARMACOGNOSTIC AND PHYTOCHEMICAL INVESTIGATION OF TWO ALPINIA SPECIES FROM ZINGIBERACEAE FAMILY

Preliminary phytochemical screening was helpful in prediction of nature of drugs and also useful for the detection of different constituents present in different polarity solvent. So it could be helpful to extract out particular constituents by solvent (Harborne et al., 1998). The phytochemical study of Alpinia galanga revealed the presence of alkaloids, tannins, terpenoids and phenolics, alkalo ids, carbohydrates, tannins, aminoacids, and saponins, while the phytochemical study of Alpinia officinarum revealed the presence of alkaloids, tannins, coumarins, terpenoids and phenolics, carbohydrates, tannins, glycosides, amino acids, phenols, gums and saponins. All the extracts of Alpinia galanga and Alpinia officinarum are brown to brownish yellow in colour and showed semisolid consistency while aqueous extract is brown in colour and showed solid consistency.
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