alternative exon
Identification and characterization of alternative exon usage linked glioblastoma multiforme survival
... [1-3]. Alternative splicing can be divided into three broad categories; intron reten- tion, cryptic splice-site usage, and alternative exon usage (AEU) or exon ...skipping. Alternative ...
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Lineage specific splicing of a brain enriched alternative exon promotes glioblastoma progression
... Tissue-specific alternative splicing is critical for the emergence of tissue identity during development, yet the role of this process in malignant transformation is ...conserved, alternative exons that ...
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Functional coordination of alternative splicing in the mammalian central nervous system
... the alternative splicing (AS) levels of pairs of alternative exons belonging to the same genes was assessed using standard Spearman ...of exon pairs (y-axis) observed to have an absolute value ...
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A phylogenetic generalized hidden Markov model for predicting alternatively spliced exons
... coding exon or intron. For exam- ple, "Alternative Exon Only" is the signal pair (Beg,END- EXON A ) and emits a contiguous coding sequence with no splice ...candidate ...
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The Role of Celf2 in the Signal Induced Alternative Splicing of Lef1 Exon 6 in T Cells
... an exon is preferentially included or excluded from an mRNA ...one alternative exon in the pre-mRNA of transcription factor LEF1 and its regulation by the splicing factor ...of exon 6 in LEF1 ...
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Pathological and prognostic role of mdig in pancreatic cancer
... from exon 1 and exon 10 regions of mdig gene, respectively, which amplifies a 1,510 bp fragment of mdig mRNA encompassing the entire open reading ...entire exon 2 region was spliced out with or ...
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Combined single cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity
... Next, we set out to study the differences between differ- ent exons and their splicing patterns. We classified cas- sette exons into five categories, using a scheme similar to that of Song et al. [12]: (1) excluded, (2) ...
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Functional coordination of alternative splicing in the mammalian central nervous system
... the alternative splicing (AS) levels of pairs of alternative exons belonging to the same genes was assessed using standard Spearman ...of exon pairs (y-axis) observed to have an absolute value ...
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The carnitine acetyltransferase gene (CRAT): A characterization of porcine transcripts with insights into the 5’-end variants of mammalian transcripts and their possible sub-cellular localization
... The alternative 5’ end of transcripts for this gene were found for human and mouse, and are reported on the Ensembl web ...the alternative exon 1 is found in normal intron 1 and the beginning of the ...
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Transcriptome wide modulation of splicing by the exon junction complex
... of alternative exons while a faster elongation could reversely modulate these ...with exon inclusion, and that some previously considered as constitutive exons became ...rescue exon skipping caused ...
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Determination Of A Comprehensive Alternative Splicing Regulatory Network And The Combinatorial Regulation By Key Factors During The Epithelial To Mesenchymal Transition
... also generally adhere to this position-dependent RNA-map (Zhang et al. 2008; Warzecha et al. 2010; Dittmar et al. 2012; Wang et al. 2012; Hall et al. 2013). The mechanism underlying the position-dependent regulation is ...
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Molecular subtypes of gastrointestinal stromal tumors and their prognostic and therapeutic implications.
... status of individual nodules within a dominant tumor mass confirmed intra- and inter-lesional mutational heterogeneity between co-existing nodules. In total, 83% of samples had at least one secondary mutation, 67% had ...
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PCBP1 inhibits the expression of oncogenic STAT3 isoform by targeting alternative splicing of STAT3 exon 23
... Figure 4. Overexpression of PCBP1 reduces the ratio of STAT3α/β and suppresses the cell proliferation of a breast cancer cell line (MCF-7). (A, B) MCF-7 cells were stably transfected with T7 tagged PCBP1 or control ...
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Genetic and molecular characterization of the Rev protein of equine infectious anemia virus
... BINDING OF EQUINE INFECTIOUS ANEMIA VIRUS REV TO AN EXON SPLICING ENHANCER MEDIATES ALTERNATIVE SPLICING AND NUCLEAR EXPORT OF VIRAL mRNA Abstract Introduction Materials and Methods... R[r] ...
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Unproductive alternative splicing and nonsense mRNAs: A widespread phenomenon among plant circadian clock genes
... extensive alternative splicing yielding nonsense mRNAs of clock genes is demonstrated beyond ...of alternative splicing in clock genes to the overall background in Arabidopsis? Is it the case that the clock ...
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Molecular Characterization and Alternative Splicing of a Sodium Channel and DSC1 Ortholog Genes in Liposcelis bostrychophila Badonnel (Psocoptera: Liposcelididae)
... with exon G2 and 53.7% with exon k in para, much higher than with exon 27B or ...27D. Exon 27C shared no significant amino acid homology with exon G3 and harbored no in-frame stop ...
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Changes in alternative splicing of human and mouse genes are accompanied by faster evolution of constitutive exons
... Studying alternative splicing requires extensive sampling of the transcriptome, but new data sets based on expressed sequence tags aligned to chromosomes make it possible to study alternative splicing on a ...
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A functional analysis of G23A polymorphism and the alternative splicing in the expression of the XPA gene
... luciferase gene expression under the transcriptional and translational control of the XPA promoter, and 5’UTR in either the wild-type or polymorphic version using a reporter assay described below under “Functional assay ...
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Multiple effects of curcumin on promoting expression of the exon 7-containing SMN2 transcript
... Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder with an estimated incidence of 1 in 6000 live births, representing the primary genetic cause of infant mortality (Monani 2005; Burghes and ...
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E Cadherin exon 4 5, exon 7, exon 8, exon 9 and exon 16 mutations in sporadic infiltrating ductal carcinoma of the breast
... exons. Exon 4-5 is the extracellular domain of the protein. Exon 7,8,9 is identified as muation cluster region in diffuse gastric cancer (Berx et ...
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