aminoacyl-tRNA
Aminoacyl tRNA synthetases as potential drug targets of the Panthera pathogen Babesia
... Being a crucial part of the protein translation machin- ery, aminoacyl tRNA synthetases (aaRSs) are currently being studied as drug targets for several pathogens [19– 28]. The aaRSs catalyse the addition of ...
15
Anti Aminoacyl tRNA Synthetases Antibodies in Japanese Patients with Interstitial Lung Disease
... 8 aminoacyl-tRNA synthetases (anti-ARS antibodies) histidyl (anti-Jo-1), threonyl (anti-PL-7), alanyl (anti-PL-12), glycyl (anti-EJ), isoleucyl (anti-OJ), asparaginyl (anti-KS), tyrosyl (anti-Ha) and ...
9
Computational Insights into the Accuracy and Editing of Aminoacyl tRNA Synthetases
... The importance carrying out protein synthesis correctly in biological systems cannot be overstated as proteins are fundamentally responsible for the survival of all known living organisms. This task requires that ...
116
Archaeal Aminoacyl-tRNA Synthesis: Diversity Replaces Dogma
... of aminoacyl-tRNAs is one of the core ability in living ...a tRNA with a particular amino between the aminoacyl-tRNA synthetases of numerous acid, the aminoacyl-tRNAs allow the ...
8
Recent advances in the biology and drug targeting of malaria parasite aminoacyl tRNA synthetases
... malarial aminoacyl-tRNA synthetases (aaRSs) have received the most attention for drug targeting in the last half-decade [5, ...cognate tRNA molecules in a two-step reaction ...different ...
10
FRAMESHIFT SUPPRESSION IN AMINOACYL-tRNA LIMITED CELLS
... We might add that our experiments focus on increases in ribosome frame- shifting brought about by aminoacyl-tRNA limitation, and therefore probably pertain to transl[r] ...
13
Structure-based design of mutant proteins: I. Molecular docking studies of amino acid binding to wild-type aminoacyl-tRNA synthetases. II. Structure-based design of mutant aminoacyl-tRNA synthetases for non-natural amino acid incorporation
... The aminoacyl-tRNA synthetases (AARSs) catalyze the esterification of amino acids to their cognate tRNAs (1). The accuracy of the reaction is essential due to its nature of protein biosynthesis fidelity. On ...
280
Retrovirus-Specific Packaging of Aminoacyl-tRNA Synthetases with Cognate Primer tRNAs
... human aminoacyl-tRNA synthetases, we found that only lysyl-tRNA synthetase (LysRS) is present in HIV-1, only tryptophanyl-tRNA synthetase (TrpRS) is present in RSV, and neither these two ...
5
Genetic Validation of Aminoacyl-tRNA Synthetases as Drug Targets in Trypanosoma brucei
... targets. Aminoacyl-tRNA synthetases (aaRSs) are known drug targets for bacterial and fungal pathogens and are required for protein ...asparaginyl- tRNA synthetase (AsnRS) (class IIb), and ...
13
Aminoacyl tRNA synthetases as malarial drug targets: a comparative bioinformatics study
... human aminoacyl tRNA synthetase sequences were retrieved from UniProt database and grouped into 20 families based on amino acid ...Plasmodium aminoacyl tRNA synthetases as potential drug ...
27
Relaxed Substrate Specificity Leads to Extensive tRNA Mischarging by Streptococcus pneumoniae Class I and Class II Aminoacyl tRNA Synthetases
... IMPORTANCE Streptococcus pneumoniae is a common causative agent of several debilitating and potentially life-threatening in- fections, such as pneumonia, meningitis, and infectious endocarditis. Such infections are ...
10
Expanding the biosynthetic capacity of the aminoacyl-tRNA synthetases
... Studies on LeuRS are not as thorough as those of IleRS and ValRS. Sequences of LeuRS from many organisms have been identified (68). LeuRS is a monomeric enzyme with 800-1000 amino acid residues and belongs to the class I ...
68
Mitochondrial aminoacyl-tRNA synthetase disorders: an emerging group of developmental disorders of myelination
... DARS2 encodes mitochondrial aspartyl-tRNA synthe- tase (mtAspRS), the enzyme that attaches aspartate to the correct mitochondrial tRNA. This step is a necessary prerequisite in the translation of ...
15
Computational Insights into the High-Fidelily Catalysis of Aminoacyl-tRNA Synthetases
... mis-aminoacylate tRNA Gln and tRNA Asn with glutamate and aspartate amino acids, ...Gln- tRNA Gln and Asn-tRNA Asn by Glu-tRNA Gln and Asp-tRNA Asn ...
270
Reaction of anti OJ autoantibodies with components of the multi enzyme complex of aminoacyl tRNA synthetases in addition to isoleucyl tRNA synthetase
... believed to be glutaminyl-tRNA synthetase. Despite reaction of some sera with additional synthetases, the immunoprecipitated tRNA appeared the same with all sera, and functioned as tRNA(ile). While ...
10
Growth-Dependent DNA Breakage and Cell Death in a Gyrase Mutant of Salmonella
... and were discarded. The remaining isolates could be separated at restrictive temperature. We found such suppressor into two classes: those still incapable of growing at 37⬚ (class mutations in genes encoding ...
10
N-Terminal Protein Modification by Aminoacyl Transferase: Enzymology and Applications.
... cognate aminoacyl tRNA anticodons versus a single mismatch at the ...misacylated tRNA is supplied; however, when in competition with correctly acylated tRNA, the ribosome shows a clear ...
282
Mutations in elongation factor EF-1 alpha affect the frequency of frameshifting and amino acid misincorporation in Saccharomyces cerevisiae.
... Amino acid substitutions located adjacent to a putative aminoacyl-tRNA binding region also suppress frameshift and nonsense mutations.. These mutations may alter the bindi[r] ...
12
Self assembly of temperature responsive protein–polymer bioconjugates
... Recent studies have shown that the introduction of noncanonical amino acids (ncAAs) into a functional protein expands the available chemistries for conjugation, 66 allowing a higher degree of precision and minimization ...
11
Understanding the Organization and functional Control of Polysomes by integrative Approaches
... To do this, the models complexity has been increased over the years, for example by introducing aminoacyl- tRNA or ribosome competition (i.e. nonspecific binding of aminoacyl[r] ...
173