Aneuploid Cells
Case Report of Ring Chromosome 13: 46,XX,r(13)(p13q34)/46,XX,dic r(13;13)(p13q34;p13q34)
... the cells with secondary chromosomal abnormalities, which according to this parameter, can be considered ...secondary aneuploid cells, and the rate of mosaicism ...
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The relationship between hypoxia, proliferation and apoptosis in murine CaNT tumours and human HT29 xenografts
... Diploid cells from both freshly disaggregated CaNT tumours and HT29 xenografts have been found to bind less NITP than ...38% aneuploid hypoxic cells (mean ...in cells from these xenografts was ...
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Tumor suppression and inhibition of aneuploid cell accumulation in human brain tumor cells by ectopic overexpression of the cyclin dependent kinase inhibitor p27KIP1
... aneuploid cells. Diminished malignant potential of Adp27KIP1-infected cells was manifested by the loss of anchorage-independent growth in soft agar and by the inability to induce tumorgenesis in a ...
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The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity
... of aneuploid cells imposes selection pres- sure favouring euploid ...stem cells (HSC) with in- creased rates of chromosome mis-segregation and subjected them to serial transplantation experiments ...
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Cryptococcus neoformans, Unlike Candida albicans, Forms Aneuploid Clones Directly from Uninucleated Cells under Fluconazole Stress
... aneuploid cells. One is the possibility of preexistence of aneuploid cells in the naive H99 popu- lation and exposure to FLC selecting for those chr1 disomic ...preexisting aneuploid ...
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Dürrbaum, Milena Rosa (2017): A systems biology perspective on the consequences of aneuploidy in human cells. Dissertation, LMU München: Fakultät für Biologie
... of aneuploid cells is due to a deficiency in HSF1 function, aneuploid cells with increased levels of HSF1 may be protected against this ...that cells that gained chromosome 8 with the ...
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Donnelly, Neysan (2016): Aneuploidy impairs protein folding and genome integrity in human cells. Dissertation, LMU München: Fakultät für Biologie
... in aneuploid cells, coupled with the rescue in both HSP90 levels and protein folding that is observed upon HSF1 overexpression, seem to offer a relatively straightforward solution to this ...trisomic ...
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Identification of mosaic and segmental aneuploidies by next-generation sequencing in preimplantation genetic screening can improve clinical outcomes compared to array-comparative genomic hybridization
... The presence of two or more distinct cell lines that exist in the same embryo is known as mosaicism, which is mainly caused by mitotic errors [5, 6]. Im- proper segregation of chromosomes in the first three cleavage ...
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Stingele, Silvia (2013): The consequences of aneuploidy in human cells. Dissertation, LMU München: Fakultät für Biologie
... on aneuploid tissues and embryos documented that changes in chromosome number lead to growth retardation and in most cases to embryonic lethality (Segal and McCoy 1974; Hodgkin, Horvitz et ...of cells with ...
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Is the hypothesis of preimplantation genetic screening (PGS) still supportable? A review
... be aneuploid, raising the specter of false-negative TEBs ...as aneuploid, led us [32, 37] and others [38] to transfer such embryos, resulting in surprisingly high normal live birth rates and so far, no ...
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Arrested human embryos are more likely to have abnormal chromosomes than developing embryos from women of advanced maternal age
... was aneuploid, and the rates increased with maternal ...the aneuploid rate observed in the present study was higher than those reported in the previous studies ...high aneuploid rate in the arrested ...
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A COLD-SENSITIVE ZYGOTIC LETHAL CAUSING HIGH FREQUENCIES OF NONDISJUNCTION DURING MEIOSIS I IN DROSOPHILA MELANOGASTER FEMALES
... The differences i n survival probably are for the most part a re- flection of the frequency of aneuploid zygotes which arise from different fre- quencies of meiotic non[r] ...
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Molecular mapping of wheat: major genes and rearrangements in homoeologous groups 4, 5, and 7.
... All probes that identified loci on the short arm of wheat chromosome 4A hybridized to the long arms of chro- mosomes 4B and 4D as revealed by linkage or aneuploid anal[r] ...
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Trichoderma reesei meiosis generates segmentally aneuploid progeny with higher xylanase-producing capability
... Results: Through genetic and genomic analyses, we show that the 16 ascospores are generated via meiosis followed by two rounds of postmeiotic mitosis. We also found that the haploid genomes of CBS999.97(1-2) and QM6a are ...
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Luminal A and luminal B (HER2 negative) subtypes of breast cancer consist of a mixture of tumors with different genotype
... all aneuploid breast cancers in the present study dis- played CIN+ features and vice versa in agreement with previous reports ...The aneuploid/CIN+ status was the major underlying phenotype in the luminal B ...
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MODULATION OF PROTEIN LEVELS IN CHROMOSOMAL DOSAGE SERIES OF MAIZE: THE BIOCHEMICAL BASIS OF ANEUPLOID SYNDROMES
... While the altered relative levels of enzymes or structural proteins might play a role i n the detrimental effects observed with chromosomal variation, it is proposed that the major im[r] ...
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GENETICS OF CATALASE IN DROSOPHILA MELANOGASTER: RATES OF SYNTHESIS AND DEGRADATION OF THE ENZYME IN FLIES ANEUPLOID AND EUPLOID FOR THE STRUCTURAL GENE
... Based on kinetic studies of catalase synthesis in flies aneuploid and euploid for region 75D-76B, we suggest that these techniques can be readily applied to a n examin[r] ...
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TRANSLOCATIONS BETWEEN THE X AND THE Y CHROMOSOMES OF DROSOPHILA MELANOGASTER
... males were determined; the salivary chromosome break point in the X and the arm of the Y involved were also determined, and the viability of the various types of aneuploid pr[r] ...
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Polyploid Titan Cells Produce Haploid and Aneuploid Progeny To Promote Stress Adaptation
... daughter cells is ploidy variation and aneuploidy in ...daughter cells carried multiple ...neoformans. Aneuploid and diploid hybrid strains formed by crossing ...Fluconazole-resistant ...
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THE MECHANISM OF SOMATIC ASSOCIATION IN COMMON WHEAT, TRITICUM AESTIVUM L. II. DIFFERENTIAL AFFINITY FOR COLCHICINE OF SPINDLE MICROTUBULES OF PLANTS HAVING DIFFERENT DOSES OF THE SOMATIC-ASSOCIATION SUPPRESSOR
... Studies on the effect of the somatic-association genes in aneuploid wheat plants having different doses of chromosomes 5B, 5D, and 5A have shown that this bal- ance can be shifted [r] ...
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