angiotensin receptor type 1 (at1r)
Increase of angiotensin II type 1 receptor auto-antibodies in Huntington’s disease
... HD subjects were recruited at the Department of Neurology, Ruhr University of Bochum. 132 genetically confirmed HD mutation carriers (72 (54.5%) women and 60 (45.4%) men; mean age 46.9 ± 12.8 years) were screened for ...
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Prolonged fasting activates Nrf2 in post weaned elephant seals
... by angiotensin II (Ang II), in a TGF-β-independent manner, during acute stimulation (Block et ...the angiotensin receptor type 1 (AT1) increases Smad2 phosphorylation in the skeletal ...
9
Ang II-AT2R increases mesenchymal stem cell migration by signaling through the FAK and RhoA/Cdc42 pathways in vitro
... Ang II transduces cell signaling upon binding to its re- ceptors, namely angiotensin II type 1 receptor (AT1R) and angiotensin II type 2 receptor (AT2R). However, no ...
13
Apelin is a positive regulator of ACE2 in failing hearts
... of Angiotensin II to Angiotensin ...of angiotensin II type 1 recep- tor (AT1R) rescued the impaired contractility and hypertrophy of apelin mutant mice, which was accompanied by ...
10
Rho-Associated Coiled-Coil Kinase (ROCK) in Molecular Regulation of Angiogenesis
... II: angiotensin II; AT1R: Ang II type 1 receptor; AT2R: Ang II type 2 receptor; CCM2: cerebral cavernous malformations 2; EC: endothelial cell; ECM: extracellular matrix; EGF: ...
17
Altered irisin/BDNF axis parallels excessive daytime sleepiness in obstructive sleep apnea patients
... ACE: Angiotensin converting enzyme; AHI: Apnea-hypopnea index; apoA1: Apolipoprotein A1; apoB: Apolipoprotein B; ARB: Angiotensin receptor (type 1) blocker; BDNF: Brain-derived ...
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Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes
... (Ang) type 1 (AT1) receptor genes, Agtr1a and Agtr1b ...AT2 receptor does not exert acute depressor effects in these mice lacking AT1 ...another receptor such as AT2 is functionally ...
7
Evidence for the importance of angiotensin II type 1 receptor in ischemia induced angiogenesis
... the angiotensin II (ATII) type 1 (AT1) receptor plays an important role in ischemia- induced ...ATII type 1a receptor knockout (AT1a –/– ) ...AT1 receptor blocker ...
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Type 1 angiotensin receptors on macrophages ameliorate IL 1 receptor–mediated kidney fibrosis
... diseases, type 1 angiotensin (AT1) receptors are present on the immune cells that infiltrate the renal ...AT1 receptor deficiency exacerbates kidney fibrosis induced by unilateral ureteral ...
7
Effects of an Angiotensin II Type 1 Receptor Blocker on Cardiovascular Calcification
... Indeed, at the time of writing, two clinical trials were recruiting patients to examine the effects of ARBs. ROCK-AS (the potential of candesartan to retard the progression of aortic stenosis), by Kupari et al., is ...
154
Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth
... Measurement of tissue monocyte chemoattractant protein–1 and VEGF levels. Because infiltration of macrophages is associated with expression of chemokine MCP-1, we determined tissue levels of monocyte ...
10
Molecular modeling of angiotensin type 1 receptor for angiotensin receptor blockers
... The preferential binding of benzophenone photo labels to methionine residues in the target structure has enabled us to design an experimental approach called the methionine proximity assay, which is based on systematic ...
5
Genetic associations between genes in the renin-angiotensin-aldosterone system and renal disease: a systematic review and meta-analysis
... with type 2 diabetes and nephropathy compared with individuals with type 2 diabetes mellitus (without nephropathy) in an East Asian population (ACE insertion compared with ...with type 2 diabetes and ...
9
Effects of angiotensin converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure Role of kinins and angiotensin II type 2 receptors
... Histopathological study. After the hemodynamic and ventriculo- graphic studies, the rats were killed and the chest opened. The heart was excised and weighed and the LV sectioned transversely into four slices from apex to ...
11
Chimeric mice carrying 'regional' targeted deletion of the angiotensin type 1A receptor gene Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells
... Renin expression in regional KO mice. We next examined whether the abnormal phenotypes observed in Agtr1a 2/2 mice (i.e., upregulation of JG renin synthesis and hypertrophic renal interlobular arteries) involves a local ...
12
CS-866, a New Angiotensin II Type 1 Receptor Antagonist, Ameliorates Glomerular Anionic Site Loss and Prevents Progression of Diabetic Nephropathy in Otsuka Long-Evans Tokushima Fatty Rats
... of angiotensin II in the patho- genesis of diabetic nephropathy remains to be elu- ...II type 1 receptor antagonist made it possible to differentiate the pathophysiologic prop- erties of ...
9
The angiotensin II receptors type 1 blockage affects the urinary bladder activity in hyperosmolar-induced detrusor overactivity in rats: Preliminary results
... Telmisartan (Sigma-Aldrich, Germany), a non-peptide AT1 angiotensin II receptor antagonist, was used in the following study. Telmisartan was dissolved in DMSO and in 0.9% saline to a final concentration of ...
5
Olmesartan for non alcoholic steatohepatitis complicated with hypertension: An open label study
... an angiotensin type 1 receptor blocker, in pa- tients with non-alcoholic steatohepatitis (NASH) com- plicated with ...acid, type IV collagen, and procollagen III N- terminal propeptide ...
6
Angiotensin II receptor blocker telmisartan attenuates aortic stiffening and remodelling in STZ-diabetic rats
... either angiotensin-converting en- zyme inhibitors or Ang II type 1 receptor blockers (ARBs) has been reported to improve CV outcomes and reduce the risk of micro- and macrovascular ...
10
Ontogeny of type 1 angiotensin II receptor gene expression in the rat
... the type 1 angiotensin II receptor (AT1) gene is developmentally regulated and whether the regulation is tissue specific, AT1 mRNA levels were determined by Northern blot analysis in livers ...
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