anti-CD20 antibodies
A new approach to comparing anti-CD20 antibodies: importance of the lipid rafts in their lytic efficiency
... humanized, anti-CD20 mAb which binds to a portion closer to the B-cell membrane, and which is composed of the 74–80 amino acids in its small extracellular loop (Figure ...from CD20 than RTX and ...
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B cell subpopulations in humans and their differential susceptibility to depletionwith anti CD20 monoclonal antibodies
... by anti-CD20 antibodies either because of local defective eff ector mechanisms or because the B cells have a particular phenotype that renders them resistant to depletion in association with their ...
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CD20 monoclonal antibody targeted nanoscale drug delivery system for doxorubicin chemotherapy: an in vitro study of cell lysis of CD20-positive Raji cells
... free anti-CD20 antibodies; the fifth lane included the subunits of anti-cD20 in acNP-DOX- DsPe-Peg2000-anti-cD20; the sixth lane had no subunits of anti-cD20 ...
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Utility of oral fluid samples for hepatitis B antibody detection in real life conditions
... the anti-HBc assay with oral fluid samples demonstrated high specificities in all groups/subgroups (over ...the anti-HBc assay using oral fluid vary between groups and subgroups; from ...of anti-HBc ...
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Antibodies directed against endogenous and exogenous citrullinated antigens pre date the onset of rheumatoid arthritis
... these antibodies have a potential role in the pathogenesis of RA that could not be completely explained by, ...e.g., anti- CEP-1, anti-Fibß36-52 or anti-filaggrin antibodies alone and ...
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Next-generation anti-CD20 monoclonal antibodies in autoimmune disease treatment
... already undergone phase III trials and was approved by the Ministry of Health of the Russian Federation in May 2014 [57]. The FDA has approved four biosimilars (Zarxio, Inflec- tra, Erelzi, and Amjevita) since 2015, and ...
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Anti carbamylated protein antibodies in the pre symptomatic phase of rheumatoid arthritis, their relationship with multiple anti citrulline peptide antibodies and association with radiological damage
... in anti-CCP2 posi- tive ...is, anti-CEP-1, −Fibß36-52 and – Fil307-324) in anti-CarP positive patients (24 months; (ß = ...of anti-CarP antibodies was associated with a higher Larsen ...
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A profile of immune response to herpesvirus is associated with radiographic joint damage in rheumatoid arthritis
... bilized anti-CD3 and anti-CD28 monoclonal antibodies (anti-CD3/anti-CD28; Dynabeads Human T-Activator, Invitrogen, Grand Island, NY, USA); bacterial CpG oli- gonucleotides (CpG); ...
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Smoking is associated with the concurrent presence of multiple autoantibodies in rheumatoid arthritis rather than with anti citrullinated protein antibodies per se: a multicenter cohort study
... of anti- citrullinated protein antibodies (ACPA) led to a paradigm shift in the field of RA risk factor analysis, because many known predisposing factors were found to be specifically associated with ...
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Parietal and intravascular innate mechanisms of vascular inflammation
... [28,30,31]. Antibodies in turn promote neutrophil activation, NETosis and persistence of NETs through: (a) the direct engagement of surface mole- cules, such as self-antigens like LL37 peptide, MPO and PR3 [32], ...
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Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review
... for anti-double-stranded DNA antibodies, anti-C1q antibodies, B-lymphocyte stimulator and tumour necrosis factor-like weak inducer of apoptosis, none of the biomarkers stood out from the ...
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The clinical relevance of autoantibodies in scleroderma
... of anti-Scl-70 and anti-U1-RNP antibodies in the sera yields a speckled appearance, whereas anti-Th/To, anti-AFA, and anti-PM- Scl give a nucleolar staining ...pattern. ...
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High serum sCD163/sTWEAK ratio is associated with lower risk of digital ulcers but more severe skin disease in patients with systemic sclerosis
... can be detected in body fluids [5-7]. Both membrane bound and soluble CD163 (sCD163) exert strong anti-inflammatory effects [8]. Uptake of haptoglobin- haemoglobin complexes by CD163-expressing macro- phages leads ...
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Original Article Autoimmune hepatitis in patients with primary Sjögren’s syndrome: a series of two-hundred and two patients
... (ALT), anti- mitochondrial antibodies (AMA), anti-nuclear antibod- ies (ANA), anti-smooth muscle antibodies (SMA), as- partate transaminase (AST), autoimmune hepatitis (AIH), gamma ...
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Immunotherapy with FBTA05 (Bi20), a trifunctional bispecific anti CD3 x anti CD20 antibody and donor lymphocyte infusion (DLI) in relapsed or refractory B cell lymphoma after allogeneic stem cell transplantation: study protocol of an investigator driven, open label, non randomized, uncontrolled, dose escalating Phase I/II trial
... IgG2b chain, each with their respective light chains. It therefore possesses two specific and one functional bind- ing site. FBTA05 binds with one binding arm to the CD3 antigen on T cells and with the second binding arm ...
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Anti-CD20 Treatment of Giant Cell Hepatitis With Autoimmune Hemolytic Anemia
... up to 134 times the upper limit of nor- mal at 3 to 16 months of age. Three out of 4 patients had jaundice at pre- sentation. They all had Coombs-positive hemolytic anemia and negative auto- antibodies. All other ...
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‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26 and anti-VGCC
... for anti-neural autoantibodies is important in patients presenting with idiopathic cerebellar ataxia, since these autoantibodies may indicate cancer, determine treatment and predict ...(e.g. anti-Hu, ...
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Hepatitis B virus strains from Rwandan blood donors are genetically similar and form one clade within subgenotype A1
... Data were aggregated on analyses for HBsAg in sam- ples from all voluntary non-remunerated first time and repeat blood donors in Rwanda recruited county-wide from five different Regional Centers for Blood and Transfusion ...
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Study of nonstandard auto-antibodies as prognostic markers in auto immune hepatitis in children
... with anti- chromatin antibodies and those without in the mean ALT (6xN versus 12xN respectively) (p = ...+ve anti-chromatin antibodies have lower levels of transaminases at presentation than ...
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Anti carbamylated protein antibodies as a new biomarker of erosive joint damage in systemic lupus erythematosus
... and anti-CarP, seem to play a pathogenetic role by acting on bone-resorbing ...in anti-CarP-positive patients with ...between anti-CarP titers and inflammatory parameters, such as US inflammatory ...
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