Anti-HER2/neu
![Synthesis of Gemcitabine (C4 amide) [anti HER2/neu] Utilizing a UV Photoactivated Gemcitabine Intermediate: Cytotoxic Anti Neoplastic Activity against Chemotherapeutic Resistant Mammary Adenocarcinoma SKBr 3](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
Synthesis of Gemcitabine (C4 amide) [anti HER2/neu] Utilizing a UV Photoactivated Gemcitabine Intermediate: Cytotoxic Anti Neoplastic Activity against Chemotherapeutic Resistant Mammary Adenocarcinoma SKBr 3
... of HER2/neu and EGFR when they function as trophic receptor ...monotherapy, anti-HER2/neu, anti-EGFR and other therapeutic monoclonal immunoglobulin fractions re- portedly have ...
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Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/neu single chain Fv for use in ADEPT
... human anti-HER2/neu single chain Fv ...to HER2/neu with high affinity and specificity ...ECD HER2 conjugated to Sepharose ...
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Poly(Malic Acid) as a Carrier For Anticancer Drug Delivery Systems: A Mini Review
... of HER2/neu-positive human breast tumors in a xenogeneic mouse model ...against HER2/neu mRNA to block new HER2/neu receptor synthesis, anti-HER2/neu ...
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Interleukin 15 is required for immunosurveillance and immunoprevention of HER2/neu driven mammary carcinogenesis
... the HER2/neu oncoantigen and on the release of IFN-γ [2, 3, 15, ...IgG1 anti-vaccine cell antibodies suggesting that antibodies of these iso- types might have a role in long-term cancer immunopre- ...
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Simultaneous Dual Selective Targeted Delivery of Two Covalent Gemcitabine Immunochemotherapeutics and Complementary Anti Neoplastic Potency of [Se] Methylselenocysteine
... for HER2/neu (e.g. anti- HER2/neu: trastuzumab, pertuzumab), EGFR ...(e.g. anti-EGFR: cetuximab, gefitinib) [1]-[4], HER2/neu and EGFR ...(e.g. ...
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Original Article Immunohistochemical results of HER2/neu protein expression assessed by rabbit monoclonal antibodies SP3 and 4B5 in colorectal carcinomas
... Abstract: HER2/neu is an efficient target for cancer ...investigate HER2/neu expression in colorectal carcinomas using these two rabbit monoclonal HER2/neu antibodies, and to ...
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Polyethylene glycol conjugated HER2 targeted peptides as a nuclear imaging probe for HER2 overexpressed gastric cancer detection in vivo
... an anti-HER2 monoclonal antibody, has been employed as tumor-specific ligands for breast cancer and GC with HER2 overexpression in vitro and in vivo ...for HER2-positive breast cancer therapy ...
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Novel EXO-T vaccine using polyclonal CD4<sup>+</sup> T cells armed with HER2-specific exosomes for HER2-positive breast cancer
... heterologous HER2/Neu-specific T cell vaccine may induce more effective anti-HER2 CTL ...(AdV HER2/Neu ) expressing a fused cDNA fragment (Hu/Rt HER2/Neu) encoding ...
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Systematic assessment of HER2/neu in gynecologic neoplasms, an institutional experience
... In endometrial and ovarian carcinomas, as in breast cancer, there have been several studies showing the amplification of the HER2 gene is associated with chemo-resistance and poor prognosis. Transtuzumab combined ...
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Review Article Genetic heterogeneity of HER2/Neu in breast carcinoma: a meta analysis
... from anti-HER2 therapy ...defining HER2 status [17-19]. HER2 genetic heterogeneity (GH) would affect the selection of patients for trastuzumab according to the American Society of Clinical ...
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Evaluation of the Antitumor Activity of Dacomitinib in Models of Human Bladder Cancer
... and HER2 overexpression, suggesting that biomarker-based patient enrichment is ...with HER2-positive urothelial cancer, trastuzumab combined with paclitaxel, carboplatin, gemcitabine chemotherapy resulted ...
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Effects of HSP90 inhibitor 17 allylamino 17 demethoxygeldanamycin (17 AAG) on NEU/HER2 overexpressing mammary tumours in MMTV NEU NT mice monitored by Magnetic Resonance Spectroscopy
... No significant changes were seen in vivo by 31 P MRS, possibly because the tumours regressed so rapidly that the signal/noise from the treated tumours was too low for effects to be quantifiable. Studies performed on ...
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Expression of anaplastic lymphokinase and HER2/neu immunostaining in patients with breast carcinoma
... Methods: This is a cross sectional multicenter study carried out from October 2016 to March 2017. A total of 140 subjects having breast carcinoma by using non-probability purposive sampling technique were selected. After ...
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Alphavirus replicon particles containing the gene for HER2/neuinhibit breast cancer growth and tumorigenesis
... Ikuta and colleagues [43] identified a K(d)-restricted pep- tide for mouse HER2/neu. The identical sequence (PYVS- RLLGI) is present in rat HER2/neu. We therefore ordered a tetramer containing ...
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Hormone sensing cells require Wip1 for paracrine stimulation in normal and premalignant mammary epithelium
... eosin; HER2: human epidermal growth factor receptor 2, also known as neu or ErbB2; HPRT: hypoxanthine-guanine phosphoribosyltransferase; IGF2: insulin-like growth factor 2; KO: knockout; MAPK: ...
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Determining the Role of Autophagy in HER2/neu-Induced Mammary Tumor Dormancy and Recurrence
... The inhibition of autophagy as a strategy to treat patients with various types of cancer is currently being tested in many clinical trials. However, determining the multiple roles of autophagy in malignant pathogenesis ...
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Role of HER2 / neu expression in colorectal carcinomas and its correlation with histological grades
... cells. HER2 receptors are expressed in low levels on the surface of ...shows HER2/neu overexpression and its ...of HER2/neu in tumours of colorectal region varies from 0% to ...
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Incorporating gold nanoclusters and target-directed liposomes as a synergistic amplified colorimetric sensor for HER2-positive breast cancer cell detection
... oncogene HER2/neu or c-erbB-2, and its overexpression is present in approximately 20%-30% of human breast cancers ...cancer, HER2-positive breast cancer, mainly due to HER2 gene amplification ...
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Original Article Clinical and pathological characteristics of extramammary Paget’s disease: report of 246 Chinese male patients
... EMPD. HER2/neu, Ki67, P53, CK20 and S100 exhibited various expression levels; analysis of these four markers and EMPD pathological features revealed a signifi- cant correlation between ...
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Clinical significance of Akt and HER2/neu overexpression in African American and Latina women with breast cancer
... in HER2/neu-overex- pressing breast tumors resistant to ...with HER2/neu-positive breast ...in HER2/ neu-overexpressing breast ...
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