Anti inflammatory and Anti histaminic activity

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Anti inflammatory and Anti histaminic activity of Kurosani Omam (Hyoscyamus Niger) for Karappan and Anti-ulcerogenic action and efficacy of Panchalavana Mezhugu for Gunmam

Anti inflammatory and Anti histaminic activity of Kurosani Omam (Hyoscyamus Niger) for Karappan and Anti-ulcerogenic action and efficacy of Panchalavana Mezhugu for Gunmam

decrease the rate of renewal of surface epithelial cells while aspirin increase the rate of exfoliation of surface epithelial cells. An increased loss of mucosal cells without a concomitant increase in cell replacement could lead to a patchy mucosal denucleation, erosions and bleeding. Aspirin induces gastric ulcers by causing back diffusion of H + ions into the mucosal cells. In pyloric ligation, ulcers are caused by acid and peptic activity. The stomach digestive effect of accumulated gastric juice in the induction of gastric ulcers is well documented in the pylorus ligation model.
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ACTINIOPTERIS RADIATA (LINN.): A COMPREHENSIVE REVIEW

ACTINIOPTERIS RADIATA (LINN.): A COMPREHENSIVE REVIEW

Actiniopteris radiata Linn. is an important medicinal plant, is fern widely distributed throughout Africa and adjacent Islands, Madagascar, Arabia, Iran, Afghanistan, Nepal, India, Sri Lanka, Burma and Australia. The plant contains several chemical constituents like Hentriacontane, Hentriacontanol, Hentriacontanone, β-sitosterol, Quercetin-3- rutinoside, β-sitosterol palmitate. The plant is claimed to possess anti-histaminic activity, anti-cholinergic, anti-microbial activity, anti-inflammatory activity, anti-helmenthic activity, analgesic activity, anti-tubercular activity and used as styptic. The present article reveals the detailed exploration of phytoconstituents and pharmacological activities of Actiniopteris radiata is an attempt to provide for further research.
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  EVALUATION OF ANTIASTHMATIC ACTIVITY OF DRIED WHOLE PLANT EXTRACT OF LEUCAS ASPERA USING VARIOUS EXPERIMENTAL ANIMAL MODELS 

  EVALUATION OF ANTIASTHMATIC ACTIVITY OF DRIED WHOLE PLANT EXTRACT OF LEUCAS ASPERA USING VARIOUS EXPERIMENTAL ANIMAL MODELS 

pigs, PCT was increased in methanolic extract of L. aspera as compared to control group. Methanolic extract of Leucas aspera significantaly raised the PCT in histamine induced bronchospasm. Thus, anti-histaminic activity and bronchodilating activity was obtained. It also prevented paw edema in passive paw anaphylaxis model. The egg albumin induced paw edema leads to inflammation in hind paw of rat. The differences in hind paw volume after egg albumin injection was decreased in rats treated with methanolic extract of L. aspera. It reveals that the plant having anti-inflammatory activity. Milk induced leucocytosis and eosinophilia was not significantaly decreased that much in mice pre-treated with methanolic extract of L. aspera before and 24 hour after milk injection. The drug treatment also significantly prevented the disruption of mast cells and release of several mediators. Acetylcholine and histamine induced contractions in guinea pig ileum and tracheal chain preparation were also significantaly inhibited by administration of methanolic extract of L. aspera.
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Anti-Histaminic and Anti-Anaphylactic Activity of Randia Dumetorum

Anti-Histaminic and Anti-Anaphylactic Activity of Randia Dumetorum

. The prevention of degranulation process by the extract indicates a possible stabilizing effect on the biomembrane of mast cells 14 . Its ability to afford protection against histamine induced bronchospasm in guinea pigs shows antihistamine like action 15 . Histamine is a central mediator in the pathogenesis of allergic and inflammatory disorders. In the present study Randia dumetorum (Retz.) Poir. prolonged the latent period of PCD in guinea pigs following histamine aerosol. This may be suggestive of an antihistaminic activity following treatment with Randia dumetorum (Retz.) Poir. It also offered protection against anaphylactic shock-induced bronchospasm in rats 11 .
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Analgesic and Anti inflammatory activity of Mutsangan Ilai Chooranam and Broncho Dilator-Anti-Spasmodic, Anti – Histaminic & Anti-Bacterial Activity of Karpoora Silajith Parpam

Analgesic and Anti inflammatory activity of Mutsangan Ilai Chooranam and Broncho Dilator-Anti-Spasmodic, Anti – Histaminic & Anti-Bacterial Activity of Karpoora Silajith Parpam

The moto of this dissertation is to prove that the drug „MUTSANGAN ILAI CHOORANAM‟ is a natural effective remedy for the disease “AZHAL KEEL VAYU”. It is one of the vadha diseases in siddha system of medicine and can be compared to the “OSTEO ARTHRITIS” in modern medicine. This is one of the non- inflammatory joint diseases. This is a most common joint disorder with knee involvement a major cause of disability.The disease is also termed as degenerative joint disease of human being.

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Efficacy and local irritation evaluation of Eriobotrya japonica leaf ethanol extract

Efficacy and local irritation evaluation of Eriobotrya japonica leaf ethanol extract

In order to determine the SOD-like activity of EJEE, SOD activity was estimated using a SOD determination kit (Sigma-Aldrich) following the manufacturer’s instructions. EJEE was prepared at different concentrations (0.1, 0.05, 0.025, 0.01, 0.005, and 0.0025% w/v). The synthetic anti-oxidant L-ascorbic acid (positive control) was used in the following concentrations: 0.0025, 0.001, 0.0005, and 0.0001% (w/v). Two hundred microliters of the sample was mixed with 2.6 mL of Tris-HCL buffer (pH 8.5) and incubated at 25 °C for 10 min, after which 0.1 mL of 1 M HCL was added to stop the reaction. The absorbance was determined in an EPOCH microplate reader at 450 nm wavelength. The tests were carried out in triplicate. The SOD activity of the test material was calculated as follows: SOD-like activity (%) = [(S1 – S3) – (SS – S2) / (S1 – S3)] × 100 (%), where S1 is the UV absorbance of blank 1 (distill water + WST working solu- tion + enzyme working solution), S2 is the UV absorbance of blank 2 (sample + WST working solution + dilution buffer), S3 is the UV absorbance of blank 3 (distill water + WST working solution + dilution buffer), SS is the UV absorbance of the test sample (sample + WST working solution + enzyme working solution).
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Research Paper In-vitro evaluation of anti-inflammatory and anti-urolithiatic activity of Cichorium intybus leaves extract

Research Paper In-vitro evaluation of anti-inflammatory and anti-urolithiatic activity of Cichorium intybus leaves extract

From the data given in Figure 1, there was a dose dependent increase in percentage protection of HRBC membrane by hydro-ethanolic extract of C. intybus leaves extract. The results showed that C. intybus leaves extract at concentration 500 μg/ml give protection to the erythrocyte. However, the percentage inhibitions of lysis shown by the extract doses were lower than that obtained for 100 μg/ml of Aspirin. As the human erythrocyte membrane resembles the lysosomal membrane the HRBC membrane stabilization has been used to study the in-vitro anti-inflammatory activity. The lysosomal contents of the neutrophils include bactericidal enzymes and proteinases, which on further extracellular release cause tissue inflammation and damage. Therefore, stabilization of the lysosomal membrane is important in limiting the inflammatory response (Leelaprakash et al., 2011).
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TO STUDY THE IN VITRO ANTI INFLAMMATORY ACTIVITY OF ACALYPHA INDICA LEAVES

TO STUDY THE IN VITRO ANTI INFLAMMATORY ACTIVITY OF ACALYPHA INDICA LEAVES

SCREENING FOR ANTI-INFLAMMATORY ACTIVITY (IN-VITRO MODELS) The leaves extracts are screened for anti-inflammatory [21] activity by using inhibition of albumin denaturation technique which were studied according to Mizushima and Kobayashi with slight modification. The standard drug and test leaves extracts were dissolved in minimum amount of dimethyl formamide (DMF) and diluted with phosphate buffer (0.2 M, pH 7.4). Final concentration of DMF in all solutions were less than 2.0%. Test solution (1 ml) containing different concentrations of drug were mixed with 1 ml of 1% mM albumin solution in phosphate buffer and incubated at 27 0 ±1 0 C in BOD incubator for 15 min. Denaturation was induced by keeping the reaction mixture at 60 0 ±1 0 C in water bath for 10 min. After cooling the turbidity were measured at 660 nm (UV-Visible Spectrophotometer SL-159, Elico India Ltd.). Percentage of inhibition of denaturation [22,23] was calculated from control where no drug were added. Each experiment was done in triplicate and average was taken. The Ibuprofen were used as standard drug. Results are tabulated in table no. 1.
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Anti histaminic effect of Chukku Chooranam for Eraippu Erumal Noi and Anti histaminic effect of Mayiliragu Saambal (Ash)

Anti histaminic effect of Chukku Chooranam for Eraippu Erumal Noi and Anti histaminic effect of Mayiliragu Saambal (Ash)

SOLUTIONS REQUIRED: Histamine – 1 in 1,00,000 strength, Anti Histamine – pheniramine maleate 2.5mg/ml Test drug – Mayiliragu saambal 50 mg/ml NUTRIENT SOLUTION: Tyrode – 1 to 2 litres TI[r]

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Anti histamine and Anti Spasmodic activity of Vennochi Chooranam and Lithotriptic and Diuretic activity of Vediuppu Chendhuram

Anti histamine and Anti Spasmodic activity of Vennochi Chooranam and Lithotriptic and Diuretic activity of Vediuppu Chendhuram

As per Siddha concept, the disease Urolithiasis (Kalladaippu) occurs due to the vitated pithaa humour, so the trial drug which has got refrigerant activity helps in bringing down the pithaa humour. From the text Gunapadam Thaathu Jeeva Vaguppu (Pg. No. 332) the trial drug Vediuppu Chendhuram has got significant Diuretic property which hastens the property of dissolving the preformed stones and the prevention of the new stone formation in the urinary system. In the Siddha Maruthuvam Pothu it is given that the derangement of Abaana Vaayu causes crystalisation of deposits in the urine due to stasis. The diuretic property of the Vediuppu Chendhuram ease the micturition of urine, thus preventing the stone formation.
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A Comprehensive Review on Coriander and its Medicinal properties

A Comprehensive Review on Coriander and its Medicinal properties

The aqueous extract of coriander seed possesses diuretic and saluretic activity, thus, validating the use of coriander as a diuretic plant in Moroccan pharmacopoeia 23 examined aqueous extract of coriander seed which was administered by continuous intravenous infusion (120 min) at two doses (40 and 100 mg/kg) to anesthetized Wistar rats. Furosemide (10 mg/kg), a standard diuretic was used as the reference drug. Excretion of water and electrolytes (sodium, potassium and chloride) in urine was measured, and glomerular filtration rate (equal to creatinine clearance) was determined. The crude aqueous extract of coriander seeds increased diuresis, excretion of electrolytes, and glomerular filtration rate in a dose-dependent way; furosemide was more potent as a diuretic and saluretic. The mechanism of action of the plant extract appears to be similar to that of furosemide which is a drug used in renal and hepatic failure, and for the treatment of hypertension. It acts at the luminal surface of the ascending limb of the loop of Henle by inhibiting the active reabsorption of chloride.
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IDENTIFICATION OF BIOLOGICAL COMPONENTS FROM POTENTIAL BONE HEALER MEDICINAL PLANTS

IDENTIFICATION OF BIOLOGICAL COMPONENTS FROM POTENTIAL BONE HEALER MEDICINAL PLANTS

wounds healing, arthritis, anti-inflammatory Anti- tubercular activity anti-microbial activities, anti- asthmatics, throat disorders, Sexual disorders, baldness, Anti-cancer drug and other pharmacological activities. We report the presence of some of the significant components decided by GC-MS analysis, FT-IR analysis. From these results, it could be concluded that C. quadrangularis, C. halicacabum and D. viscosa contains different bioactive compounds. Assessment of pharmacological activity is under progress. Hence, it is prescribed as a plant of Phyto pharmaceutical significance.
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Anti-inflammatory effects of the gorgonian Pseudopterogorgia elisabethae collected at the Islands of Providencia and San Andrés (SW Caribbean)

Anti-inflammatory effects of the gorgonian Pseudopterogorgia elisabethae collected at the Islands of Providencia and San Andrés (SW Caribbean)

Methods: Extracts from P. elisabethae were fractionated on silica gel to yield fractions: F-1 (pseudopterosins PsQ, PsS and PsU) and F-2 (amphilectosins A and B, PsG, PsK, PsP and PsT and seco-pseudopterosins seco-PsJ and seco-PsK) from chemotype 1, and F-3 (elisabethatrienol, 10-acetoxy-9-hydroxy- and 9-acetoxy-10-hydroxy-amphilecta-8,10,12,14- tetraenes (interconverting mixture) and amphilecta-8(13),11,14-triene-9,10-dione) from chemotype 2. By using preparative RP-HPLC and spectroscopic means, we obtained the pure PsG, PsK, PsP, PsQ, PsS, PsT, PsU, seco-PsK and the interconverting mixture of non-glycosylated diterpenes (IMNGD). The anti-inflammatory properties of extracts and fractions were evaluated using in vivo model "12-O-tetradecanoyl-phorbol-acetate (TPA)-induced mouse ear oedema". The activities of pure compounds and of the IMNGD were evaluated using in vitro assays myeloperoxidase (MPO) release (by human polymorphonuclear neutrophils (PMNs)), nitric oxide release (by J-774 cells) and scavenger activity on NO. Results: In the in vivo anti-inflammatory assay, extracts and F-3 showed low inhibition levels of inflammation compared to indomethacin, F-1 and F-2. Additionally, we evaluated the MPO release to the inflammation site, and found a marked inhibition of MPO levels by all extracts and fractions, even superior to the inhibition shown by indomethacin.
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Pharmacological evaluation of a novel enhydrazone ester (CEE 1) as a dual inhibitor of the release of pro inflammatory cytokines and prostanoids from human monocytes

Pharmacological evaluation of a novel enhydrazone ester (CEE 1) as a dual inhibitor of the release of pro inflammatory cytokines and prostanoids from human monocytes

Inflammation is the major cause or component of a wide range of chronic diseases such as rheumatoid arthritis, asthma, atopic dermatitis and inflammatory bowel disea- se [1-4]. Activated monocytes and macrophages contri- bute to inflammation by releasing a large number of pro- inflammatory mediators including cytokines such as TNF-α, IL-1β and IL-6; eicosanoids such as leukotrienes and prostanoids; reactive oxygen species and lysosomal enzymes [5-8]. The mediators, in concert, orchestrate the inflammatory reactions that constitute the pathophysiolo- gy of the diseases. As a result, drugs that inhibit the syn- thesis and release of cytokines (such as steroids) or block the action of cytokines such as the disease modifying anti-rheumatic drugs (DMARDs), as well as inhibitors of prostanoid synthesis such as the non-steroidal anti-in- flammatory drugs (NSAIDs), constitute the bulk of the therapeutic agents available for the management of chro- nic inflammatory diseases [9-11]. While very effective in inhibiting the synthesis of prostanoids, NSAIDs gene- rally have little or no effect on the synthesis and release of pro-inflammatory cytokines. On the other hand, DMARDs, which comprise many structurally unrelated drugs, have widely differing mechanisms of anti-inflam- matory action, but they generally have little or no effect
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Phytochemical and pharmacological review of Andrographis echiodies

Phytochemical and pharmacological review of Andrographis echiodies

Padma et al., (2012) evaluated the anthelmintic activity of ethyl acetate, methanol and aqueous extract of whole plant of Andrographis echioides against Pheretima posthuma. The results revealed that the test extracts of A. echioides exhibited significant anthelmintic activity at concentration of 50 mg/ml. The use of A. echioides as an anthelmintic has been confirmed and further studies are suggested to isolate the active principles responsible for the promising activity[14].

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Formulation and Evaluation of Polyherbal Antipsoriatic Cream

Formulation and Evaluation of Polyherbal Antipsoriatic Cream

In the present research an attempt has been made to develop antipsoriatic cream using combination of herbs like neem, sarsaparilla, bakuchi and daruhaldi. Psoriasis is an inflammatory disease of skin characterized by well defined erythematous plaque with large adherent silvery scales. Colonization and infection with S. aureus has been reported to exacerbate Psoriasis. The conventional medical treatment of psoriasis relies upon combination of treatment like using coal tar preparations, dithranol, calsipotriol, topical corticosteroids and controlled UV radiations. However, serious side effects are associated with them. Shortcomings of these conventional treatments of psoriasis encouraged us to develop effective polyherbal formulation. Experimental findings indicated that formulation F3 was most stable and efficacious and showed good antimicrobial and anti inflammatory results. Formulation F3 containing Bakuchi 1.2%, Daruhaldi 2%, Neem 1% and Sarsaparilla 1.2% offers a valuable alternative to the conventional psoriasis treatment.
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ECLIPTA ALBA (LINN.) HASSK. – A REVIEW

ECLIPTA ALBA (LINN.) HASSK. – A REVIEW

Clinical studies and Traditional Uses: Eclipta alba is used in various parts of tropical and sub-tropical regions like South America, Asia and Africa. It is an active ingredient of many herbal formulations prescribed for liver ailments and shows effect on liver cell generation. It is used as a tonic and diuretic in hepatic and spleen enlargement. It is also used as haemostatic [24] and for skin diseases. [25] The alcoholic extract of the plant has shown antiviral activity against Ranikhet disease virus. [26] The plant is commonly used in hair oil all over India for blackening, promoting hair growth and strengthening the hair. [27] The fresh juice of leaves is used for increasing appetite, improving digestion and as a mild bowel regulator. [28] The herbal drug combinations Tefroliv-forte, Stimuliv syrup containing Eclipta alba in combination with other herbs are used as hepatoprotective in drug induced, alcoholic and viral hepatitis. [29] There has been clinical studies conducted that prove the effectiveness of Eclipta alba therapy in jaundice in children. [30] Bhringaraja in “Ghanasatwavati” is used in patients of kostha-shakhasrita kamala with special reference to hepatocellular jaundice. [31] 16 parts of Eclipta prostrate (bhringaraj), 1 part of Triphala formula {Emblica officinalis (amalaki), Terminalia chebula, (haritaki), Terminalia belerica (bibhitaki)}, 1 part of Caltropis gigantean (arka) and 1 part of Smilax officinalis (sariva) mixed with 80 parts of sesame oil and boiled to make a medicated oil which is reported to be used in skin diseases. [32]
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Gold nanoparticle sucrose complexes as potent anti-inflammatory agents

Gold nanoparticle sucrose complexes as potent anti-inflammatory agents

The synthesized GNPs ~21 and ~34 nm in different concentrations, indomethacin (4 mg/kg), and methotrexate (40 mg/kg), were diluted in 0.1% DMSO (v/v in distilled water) and administered intraperitoneally (i.p.) 30 min prior to the injection of 100 µL of 2% (w/v) carrageenan solution into the plantar side of right hind paws of the rats. The dosages of the GNPs were adjusted to the same level of Au in a 0.7 mg/kg dose of myochrysine, which is an anti-inflammatory dose in rheumatoid arthritis. Paw thickness was measured with a digital caliper immediately after the carrageenan injection, which considered as the baseline value for the hind paw thickness. The degree of swelling was evaluated through changes in thickness of the right hind paw. Each of indomethacin and methotrexate (suspended in 0.1% DMSO individually) were used as positive controls and 0.1% DMSO (v/v; vehicle) as negative control, respectively. After 6 h, the animals were sacrificed and the kidney and liver were extracted, fixed and stained with a standard hematoxylin/eosin (HE) staining method for cytological evaluation of inflammatory cells infiltration and cellular damage. Blood samples of the distal tail vein were collected for determination of inflammatory markers, including TNF-α, IL-1β and IL-6.
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PHYTOCHEMICAL EVALUATION OF SEED AND FRUIT PULP EXTRACTS OF PASSIFLORA FOETIDA L

PHYTOCHEMICAL EVALUATION OF SEED AND FRUIT PULP EXTRACTS OF PASSIFLORA FOETIDA L

In the present work, the chemical constituents present in the methanolic extracts of seed and fruit pulp of Passiflora foetida L were evaluated. Based on the findings, was concluded that the presence of phytochemicals such as alkaloids, flavonoids, phenols, tannin and saponin were present in the extracts of seed and fruit pulp. Naturally occurring plant bioactive compounds are a great source, to treat various diseases. The extracts also possess biologically active constituents worthy, responsible for antibacterial, antioxidant and anticancer activity. Further study the purification of individual compounds in the methanolic extract of seed and pulp in needed to evaluate their bioactivities.
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Protective Effect of Acanthus Montanus in Carrageenan-Induced Models of Local Inflammation: Inhibitory Effect on Nitric Oxide (NO) Production

Protective Effect of Acanthus Montanus in Carrageenan-Induced Models of Local Inflammation: Inhibitory Effect on Nitric Oxide (NO) Production

In rat carrageenan inflammation, the interaction between cyclooxygenase and the NO pathway may represent an important mechanism for the modulation of the inflammatory response [13]. Mouse paw oedema and pleurisy elicited by carrageenan is less explored than rat paw and rat pleurisy but it is a useful model for study of inflammation and the same mediators are involved in both models [14, 15, 11]. It is well known that different mechanisms may be involved in the genesis of inflammatory reactions. The development of the inflammatory response induced by carrageenan is characterized by an initial stage (1-2 h) which is dependent on the release of histamine, serotonin and bradykinin, followed by a later stage (3-4 h) which is maintained principally by the release of prostanoids [16]. It has also been shown that nitric oxide (NO) has an important role as much as in the regulation of vascular permeability as in cell migration induced by pro-inflammatory agents, including carrageenan [11, 16]. Several studies have shown that NO appears to play a crucial role in modulating the generation of prostaglandins at the inflammation site [13, 15].
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