ANTI INFLAMMATORY 49 : inhibits the activity of phospholipase A2
The activity of cytosolic phospholipase A2 is required for the lysis of adenovirus-infected cells by tumor necrosis factor.
... 12. Gooding, L. R., L. W. Elmore, A. E. Tollefson, H. A. Brady, and W. S. M. Wold. 1988. A 14,700 MW protein from the E3 region of adenovirus inhibits cytolysis by tumor necrosis factor. Cell 53:341–346. 13. ...
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The potent anti Staphylococcus aureus activity of a sterile rabbit inflammatory fluid is due to a 14 kD phospholipase A2
... Figure 1. Effect of increasing concentrations of whole AF and of (partially) purified protein fractions of AF on viability of S. aureus. Incubation mixtures contained 10 6 bacteria/ml, 10 mM Hepes buffer (pH 7.4), and ...
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Inhibition of secreted phospholipase A2 by neuron survival and anti-inflammatory peptide CHEC-9
... The properties of CHEC-9 reacted with sPLA2 group I were examined using substrate concentrations that were one-half or less than the Michaelis constant (Km) meas- ured during the course of the experiments, a relationship ...
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Glucocorticoid deficiency increases phospholipase A2 activity in rats
... by phospholipase A2 ...favor inflammatory disease ...enzyme activity in adrenalectomized (ADX) rats where glucocorticoid concentrations were below physiological ...
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Comparative efficacy of a secretory phospholipase A2 inhibitor with conventional anti inflammatory agents in a rat model of antigen induced arthritis
... This is evidence that each of these facets of RA is mediated by separate, but communicating, mechanisms. sPLA 2 inhibition reduces prostaglandin synthesis by COX, through reducing the concentration of free AA, whilst ...
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Antioxidant and inflammatory aspects of lipoprotein-associated phospholipase A2 (Lp-PLA2 ): a review
... by application of drugs, many studies have also investi- gated the influence of diet and other environment factors on the enzyme. In this context, Pedersen et al. [79] com- pared the effects of high (6.6 g), low (2.0 g) ...
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Study of the Activity of Phospholipase A2 in Venom of the Transcaucasian Macrovipera Lebetina Obtusa
... phospholipases A2 (PLAs) that bind to and hydrolyse membrane phospholipids of the motor nerve terminal to cause degeneration of the nerve terminal and skeletal ...in inflammatory and degenerative disorders ...
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Secreted phospholipase A2 activity in experimental autoimmune encephalomyelitis and multiple sclerosis
... acute inflammatory response ...by phospholipase A2 is a well-known early response to tissue damage in all organ systems including the nerv- ous system ...of inflammatory media- tors and ...
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ANTI INFLAMMATORY ACTIVITY OF BACTERIA ASSOCIATED WITH MARINE SPONGE (HALICLONA AMBOINENSIS) VIA REDUCTING NO PRODUCTION AND INHIBITING CYCLOOXYGENASE 1, CYCLOOXYGENASE 2, AND SECRETORY PHOSPHOLIPASE A2 ACTIVITIES
... of inflammatory disease are corticosteroids, nonsteroidal anti-inflammatory drugs, and disease-modifying anti rheumatoid drugs, which include biological ...treating inflammatory ...
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Darapladib, a Lipoprotein Associated Phospholipase A2 Inhibitor, Reduces Rho Kinase Activity in Atherosclerosis
... in inflammatory responses and arteriosclerotic lesions in hu- mans and animals; 26-28 multiple studies have demonstrated that Rho kinase is involved in the inflammatory atherosclerotic pro- ...
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Increased Lipoprotein-associated phospholipase A2 activity portends an increased risk of resistant hypertension
... Lp-PLA2 activity on blood pressure, all participants were divided into low (< 225 nm/min/ml) and high ( ≥ 225 nm/min/ml) Lp-PLA2 activity groups based on the cut-off value of Lp-PLA2 ...Lp-PLA2 ...
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Cytosolic phospholipase A2 in hypoxic pulmonary vasoconstriction
... beneficial anti- inflammatory effects of decreased cPLA 2 activity may be greater than the detrimental effects of cPLA 2 defi- ciency on HPV and that inhibition of cPLA 2 -initiated pathways could be ...
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The role of phospholipase A2 in mast cell activation
... Mast cell chymases vary greatly in their surface charge and their binding to proteoglycans. Several of these enzymes, especially canine and rat chymase I, bind strongly to heparin^^'^^'^'^^l Human chymase has been shown ...
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Antibacterial properties of chicken intestinal phospholipase A2
... the anti- bacterial activity of 13 μg of Ch PLA2-IIA added to 10 8 cells of growing culture of gram-positive bacteria: Bacillus cereus (BC), micrococcus luteus (ML), Brevibacterium flavum(BF), ...
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Lipid metabolites of the phospholipase A2 pathway and inflammatory cytokines are associated with brain volume in paediatric cerebral malaria
... enzymatic activity also correlated to brain volume, suggesting an upregulation of the PLA 2 pathway in children with high brain swell- ...other inflammatory cytokines, TNFα is correlated with brain ...
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Secretory phospholipase A2 in SARS-CoV-2 infection and multisystem inflammatory syndrome in children (MIS-C)
... specific anti- inflammatory drugs, specific inhibitors of sPLA2 formation or activity, as well as compounds that “cloak” its target, PS exposing ...
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Anti mycobacterial and anti inflammatory activity of Peganum harmala
... and anti-inflammatory activity of the methanolic extracts of Peganum harmala (Esphand) collected from Golestan province, north of ...for anti-mycobacterial activity by disc diffusion ...
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ANTI-ULCEROGENIC ANTI-INFLAMMATORY ACTIVITY OF BUXUS WALLICHIANA
... Wallichiana.The anti-inflammatory activity of various doses of petroleum ether ,chloroform and methanol extracts were evaluated in ...that anti-inflammatory activity of petroleum ...
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A Review on Anti-Inflammatory Activity of Monoterpenes
... of anti-inflammatory substances can be an effective tool in the therapeutic treatment of the ...different inflammatory conditions, such as lung and skin ...the anti-inflammatory ...
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ANTI-INFLAMMATORY ACTIVITY OF ICHNOCARPUS FRUTESCENS
... the anti-inflammatory effect could be also related to antioxidant activity, the HAE was evaluated by the DPPH° ...The anti-inflammatory activity of these compounds might also ...
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