antitumor properties
<p>The antitumor properties of metformin and phenformin reflect their ability to inhibit the actions of differentiated embryo chondrocyte 1</p>
... Results: In the present study, we tested two guanide-containing drugs, metformin and phenformin, and found that both exhibit cytotoxicity against HeLa cervical carcinoma and A2058 melanoma cells. This effect was ...
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Synthesis and antitumor properties of bis indole derivatives
... and antitumor activity of a series of bis-indole derivatives against three human cancer cell lines, including human leukemia K562, human liver cancer HepG2 and human colon cancer ...
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Composition, in vitro antioxidant and antitumor properties of essential oil from the seeds of Moringa oleifera
... anticancer, antitumor, anti-inflammatory, diuretic properties as well as antihepatotoxic, antifertility, antiurolithiatic and analgesic activities were reported ...and antitumor activity of ...
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Safety, pharmacokinetics, and antitumor properties of anlotinib, an oral multi-target tyrosine kinase inhibitor, in patients with advanced refractory solid tumors
... for antitumor activity of anlotinib: 3 patients had partial response, 14 patients had stable disease including 12 tumor burden shrinkage, and 3 had disease ...
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Verteporfin, a suppressor of YAP–TEAD complex, presents promising antitumor properties on ovarian cancer
... To further explore the mechanisms of the antitumor effects of VP, we established OVCAR8 IP metastasis mice models. We found that treatment with VP caused a moderate but significant decrease in the tumor growth in ...
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Antitumor Potential of Antimicrobials: An Anticipated Armour for Hepatocellular Carcinoma
... Studies are being conducted to estimate the role of suratinib, brivanib, linifanib, sorafenib plus erlotinib, combination of molecular targeted drugs and cytotoxic agents such as sorafenib plus doxorubicin but ...
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Fractionated photothermal antitumor therapy with multidye nanoparticles
... Figure 1 (A) Normalized absorbance and fluorescence of multidye theranostic nanoparticles. (B) Normalized ultraviolet-visible absorbance spectra of nanoparticles before (i) and after (ii) loading of silicon ...
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New tylophorine analogs as potential antitumor agents
... The biological target of PBTs is still unknown and the mechanism of action of PBTs has not been elucidated. The preliminary results have shown that PBTs are a unique class of antitumor compounds that may have a ...
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Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids
... observed increase in cholesterol synthesis brought about by miltefosine treatment and the decrease in cholesterol esterification disturb the intracellular cholesterol/CE cycle and lead t[r] ...
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A phosphotyrosine switch determines the antitumor activity of ERβ
... The 2 estrogen receptors ERα and ERβ mediate diverse effects of estrogens in multiple tissues (1). Despite considerable sequence homology, ERα and ERβ carry out nonredundant physiological functions. While ERα is critical ...
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β-blockers: a novel class of antitumor agents
... Abstract: β-adrenergic signaling modulates key signaling pathways that are important for tumor- promoting processes, and numerous mechanisms of action have been elucidated. Preclinical studies have demonstrated that ...
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Potent antitumor property of Allium bakhtiaricum extracts
... property that may be advantageous in treating diseases involving multiple mechanisms such as cancer [54]. Al- lium vegetables have been traditionally used for centur- ies in Asian, American and European medicine to ...
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Investigation of antitumor activities of trastuzumab delivered by PLGA nanoparticles
... Results and discussion: TZ was gradually released in a prolonged way over 30 days. The physical characterization performed with circular dichroism, Fourier transform infrared and fluorescence spectroscopy of TZ after ...
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Enhanced antitumor efficacy of doxorubicin-encapsulated halloysite nanotubes
... To further illustrate the advantages of HNTs as antitumor drug carriers, we also examined the in vivo biological safety of HNTs/DOX/LIP complexes. In these experiments, we studied the biocompatibility of HNTs ...
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Antitumor Activity of Methanolic Extract of Pisonia Aculeata Leaf
... the antitumor activity of methanolic extract of Pisonia aculeata leaves extract on Ehrlich Ascites Carcinoma (EAC) in ...The antitumor effect of the extract was evaluated by using survival time, ...
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Syntheses and antitumor activity of some 1,2,4 - triazine derivatives
... and antitumor activities of the synthesized compounds 3-7 were tested against the HCT-116 cell line according to method of Mossman [15], Gandadevi and Muthumary ...
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SYNTHESIS OF ANTITUMOR AGENTS FROM NATURAL PRODUCT LEADS
... describes the synthesis of Chiral allyl alcohols using indium metal promoted by. ultrasound[r] ...
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Role of protein kinase CK2 in antitumor drug resistance
... to antitumor agents, such as downstream mechanisms of survival (reduced apoptosis, autophagy, necroptosis), and adaptive changes, due to redundant path- ways, epithelial-mesenchymal transition (EMT), and to the ...
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Enhanced antitumor activity of realgar mediated by milling it to nanosize
... administration of the two realgar preparations, with different particle sizes are presented in Figure 9. After intragastric admin- istration of realgar NPs and coarse realgar, arsenic was rapidly distributed in different ...
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QSAR Analysis on β-carboline as Antitumor Agent
... 11. Castro AC, Dany LC, Soucy F, Grenier L, Mazdiyasni H, Hottelet M, et al. Novel IKK inhibitors: β-carbolines. Bioorg Med Chem Lett 2003;13:2419-22. 12. Guan H, Chen H, Peng W, Ma Y, Cao R, Liu X, et al. Design of ...
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