Apaf-1
Kinetic Folding Studies of Apaf-1 CARD and Procaspase-3
... and co-workers (Myers et al., 1995b). It was suggested, however, that CP1-CARD contains non-native structure in the native ensemble (Chen and Clark, 2004), explaining the low m- value. The folding pathways of CP1-CARD ...
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Apoptotic protease-activating factor 1 (Apaf-1) as a liable gene for spontaneous mutations in vitro
... of Apaf-1 gene recombination during genetic ...the Apaf-1 gene with its conjugated luciferase fragment had been flanked with BamhI and XhoI restriction sites in ...the Apaf-1 ...
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Modeling of interaction between cytochrome c and the WD domains of Apaf-1: bifurcated salt bridges underlying apoptosome assembly
... WD domains (also known as WD40-repeat domains) are among the top 10 most abundant domains in eukaryotic genomes and are also widespread in bacteria [17, 18]. The common function of WD domains is to serve as scaffolds for ...
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Decreased expression of APAF-1 and increased expression of cathepsin B in invasive pituitary adenoma
... of APAF-1 and cathepsin B in relation with other molecules involved in apoptosis/proliferation and to correlate them with the aggressive behavior of invasive pituitary ...
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Aberrant Methylation of APAF-1 Gene in Acute Myeloid Leukemia Patients
... 9. Christoph F, Hinz S, Kempkensteffen C, Schostak M, Schrader M, Miller K. mRNA expression profiles of methylated APAF-1 and DAPK-1 tumor suppressor genes uncover clear cell renal cell carcinomas ...
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Aberrant localization of apoptosis protease activating factor-1 in lipid raft sub-domains of diffuse large B cell lymphomas
... dislodge Apaf-1 from the lipid rafts was a function of intracellular ROS ...of Apaf- 1 in the membrane fractions (fraction 5 as compared to fractions 4 and 5 that co-localize with flotillin), ...
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More than just inflammation: Ureaplasma species induce apoptosis in human brain microvascular endothelial cells
... Using data from RNA sequencing, we analyzed the im- pact of Ureaplasma spp. on mRNA expression of add- itional apoptosis-related genes (Fig. 3j – o), detecting a significant upregulation of caspase 7 mRNA expression ...
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PNS-R1 inhibits Dex-induced bronchial epithelial cells apoptosis in asthma through mitochondrial apoptotic pathway
... The proteins in each right lung tissue and 16HBE cells were isolated using a total protein extraction kit (KeyGen BioTECH, Jiangsu, China). Protein concentration was determined by conducting a bicinchoninic acid assay ...
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Heat shock pretreatment improves mesenchymal stem cell viability by heat shock proteins and autophagy to prevent cisplatin-induced granulosa cell apoptosis
... leading to the reduction of the apoptosis of Sca-1+ stem cells and myocardial fibrosis and the improvement of car- diac function. Therefore, we consider that the increase of anti-apoptotic ability of MSCs may be ...
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Investigation of the regulation of Bcl 2 family members in apoptosis and cancer
... A1 Bcl-2 related protein-A1 AIDS Acquired immune deficiency syndrome AMPK Adenosine monophosphate-activated protein kinase AP1 Activator protein 1 Apaf-1 Apoptotic protease activating fa[r] ...
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Original Article Wogonoside induces cell cycle arrest and mitochondrial mediated apoptosis by modulation of Bcl-2 and Bax in osteosarcoma cancer cells
... Abstract: Osteosarcoma (OS) is the most common bone cancer with a great tendency for local invasion and distant metastasis. Restricted by the severe toxicity of conventional drugs, the therapeutic challenge of ...
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A comparison of programmed cell death between species
... homolog, Apaf-1, has been extensively characterized to date, but it too aids in caspase ...CED-4, Apaf-1 requires dATP for caspase activation, but Apaf-1 requires cytochrome c in ...
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Krill oil extract suppresses the proliferation of colorectal cancer cells through activation of caspase 3/9
... kinase; APAF-1: apoptotic protease activating factor; ATCC: American Tissue Culture Collection; Bak: pro- apoptotic Bcl-2 proteins; Bcl-2: B cell lymphoma protein; COX-2: cyclo- oxygenase-2; CRC: Colorectal ...
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An overview of the role of platelets in angiogenesis, apoptosis and autophagy in chronic myeloid leukaemia
... The intrinsic apoptotic pathway in platelets, compa- rable to the process in nucleated cells, is characterised by activation of Bak and Bax, members of the B-cell lymphoma 2 (Bcl-2) protein family which promote ...
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Analysis of the expression of PHTF1 and related genes in acute lymphoblastic leukemia
... and Apaf-1 were upregu- ...and Apaf-1 expression ...tumor 1 (WT1), which was consistently found to be highly expressed in peripheral blood (PB) or bone mar- row (BM) in acute myeloid ...
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Epigenetics of human cutaneous melanoma: setting the stage for new therapeutic strategies
... In addition to biologic therapies, epigenetic drugs are expected to be successful also in combination with stan- dard cancer chemo- and radio-therapeutic approaches (Table 4). In fact, re-expression/up-regulation of ...
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Regulation of apoptosis at the point of cytochrome c in disease models
... appreciation of how primary cell types may have additional regulatory mechanisms to control the apoptotic pathway. Previous work from our laboratory has shown that various postmitotic cells, such as sympathetic neurons, ...
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Regulation of apoptosis in postmitotic cells
... additional Apaf-1 like molecule that can scaffold and activate caspase ...of Apaf-1 by released cytochrome ...for Apaf-1 using a ligand other than cytochrome c. Whether an ...
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1′ (1 Hydroxyethyl) N,N diphenylferrocene 1 carboxamide1 1
... diphenylcarboxamide moiety and a hydroxyethyl group are attached to the ferrocene skeleton. The cyclopentadienyl rings deviate only slightly from an eclipsed conformation. Two CÐ H interactions link the molecules into ...
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1-1 powerpoint.ppt
... Write an expression for the number of bottles needed to make s sleeping bags. The expression 85 s models the number of bottles to make s sleeping bags..[r] ...
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