Apoptosis and Molecular Signaling
Endometrial Carcinogenesis and Molecular Signaling Pathways
... mTOR signaling enhances translation of mRNAs encoding growth factors, cell cycle regulators, survival proteins, and angiogenic factors, therefore, dysregulation of the PI3K/AKT/ mTOR pathway as a result of genetic ...
17
Deciphering the molecular signaling cascade in neuronal death
... of apoptosis (IAP), ―second mitochondria-derived activator of caspases/direct inhibitor of apoptosis-binding protein with low pI ‖ (Smac/DIABLO) and HTRA2/OMI that activate the caspase-signaling ...
442
Molecular Signaling in Tumorigenesis of Gastric Cancer
... TGF-β signaling pathway involves in many cellular processes such as cell growth, cell differentiation, and ...During signaling, the ligands bind to the type II receptor where it catalyzes and phosphorylates ...
14
Study of Celastrol on Akt Signaling Pathway and Its Roles in the Apoptosis of K562 Cells
... and apoptosis induction in K562 cells, which was accompanied by typical apoptotic morphological and sharp decreased expression of phosphorylation level of Caspase family members and Akt signaling pathway ...
7
-induced apoptosis in cardiomyocytes via microRNA-19b/AKT/mTOR signaling pathway
... proliferation, apoptosis and cel- lular ROS levels were evaluated during this process by using MTT assay, flow cytometry analysis and 2’7’-Dichloro fluoresc in diacetate ...in apoptosis of cardiomyocytes ...
11
Signaling for survival and apoptosis in the immune system
... the molecular network governing the fate of all living ...of signaling channels initiated by TNF receptor type 1 engagement, which can lead to either cell survival or to cell ...mammalian apoptosis ...
10
Caspases: A Molecular Switch Node in the Crosstalk between Autophagy and Apoptosis
... Caspase-9 is another essential initiator caspase that is involved in the intrinsic apoptosis pathway [100, 101]. Once activated, caspase-9 is able to process downstream effector caspases, including caspase-3, -6, ...
12
Original Article Apoptosis prediction via inhibition of AKT signaling pathway by neogrifolin
... the apoptosis-inducing effects and the mechanisms of neogrifolin on human osteosarcoma ...of apoptosis in U2OS and MG63 osteosarcoma cell lines were also ...of apoptosis protein (IAP) in both ...
11
Hyperoxia accelerates Fas mediated signaling and apoptosis in the lungs of Legionella pneumophila pneumonia
... mediated signaling system may be an important devel- opmental regulator for induction of apoptosis ...inducing signaling complex through interaction with adaptor proteins, such as Fas associated ...
7
Antiproliferative and molecular mechanism of eugenol-induced apoptosis in cancer cells
... S7-S against WM, GR, PNP, GILIN and LAN-5 cell lines were found to be 27, 23, 29, 19 and 16 µM respectively. S7-S treatment resulted in significant phosphatidylserine exposure in melanoma cells. Caspase activation was ...
15
Molecular machines or pleiomorphic ensembles: signaling complexes revisited
... cell signaling would be hard-pressed to avoid terms such as ‘machinery’ and ...cell signaling and man-made machines is all-pervasive, frequently adopting the imagery of elaborate clockwork mechanisms or ...
8
Comprehensive molecular characterization of the hippo signaling pathway in cancer
... and apoptosis (Di Cara et ...Dysregulated signaling by the Hip- po pathway has been reported in several cancer types such as breast, liver, lung, prostate, gastric, and colorectal tumors (Cor- denonsi et ...
21
Molecular mechanism of apoptosis induction in skin cancer cells by the centipedegrass extract
... PI3K/AKT/GSK-3β signaling pathway is important for cell survival and ...the apoptosis cascade reaction ...suppressing apoptosis via subsequent modula- tion of several target molecules that regulate ...
9
Molecular mechanisms conferring resistance/sensitivity to glucocorticoid induced apoptosis
... of apoptosis has been provided by observations suggesting that glucocorticoids inhibit the induction of Fas-L (but not Fas) signalling in T-cell hybridomas [19, ...initiate apoptosis in these cells through ...
25
RhoA regulates resistance to irinotecan by regulating membrane transporter and apoptosis signaling in colorectal cancer
... group, siRNA control group, RhoA siRNA group, parental colorectal cancer cell group. Chemotherapeutic drugs CPT-11, L-OHP, PTX, VP16, EPI, DDP, 5-FU (Dalian Meilun Biology Technology co., LTD, China) were added at ...
11
Molecular alterations in the TCR signaling pathway in patients with aplastic anemia
... In conclusion, this is the first study to analyze the expression characteristics of the CD28, CTLA-4, and Cbl-b genes, the distribution of the CD3ζ 3′-UTR splice variant in AA patients, and the SNP rs231775 in CTLA- 4 ...
9
Atypical antipsychotics induce human osteoblasts apoptosis via Wnt/β-catenin signaling
... of molecular biology, a number of signal pathways include BMP-Smads, Wnt/ β-catenin, Notch, Hedgehog, FGF et ...Wnt/β-catenin signaling regulated osteoblast apoptosis is a new ...Wnt/β-catenin ...
10
A Novel Dual Signaling Axis for NSP 5a3a induced apoptosis in Head and Neck Carcinoma
... DAXX while seemingly more intense in treated cells with a band at approximately 95 kDa (Fig. 10). DAXX has been reported to act as a transcriptional repressor of many DNA-binding proteins [92-93], while it has been ...
20
<p>Role of Hippo/YAP signaling in irradiation-induced glioma cell apoptosis</p>
... the transportation of Yes-associated protein (YAP) to nuclear, thereby inhibiting the transcription of its down- stream genes. 8,9 Notably, studies have con fi rmed that Hippo/YAP signaling plays a crucial role in ...
9
Molecular mechanisms of cell cell signaling by the Spemann Mangold organizer
... ABSTRACT We review how studies on the first Spemann-Mangold organizer marker, the homeobox gene goosecoid, led to the discovery of secreted factors that pattern the vertebrate embryo. Microinjection of goosecoid mRNA ...
9