apoptotic protease-activating factor 1 (Apaf-1)
Apoptotic protease-activating factor 1 (Apaf-1) as a liable gene for spontaneous mutations in vitro
... is Apoptotic protease-activating factor 1 (Apaf- 1) ...to Apaf-1 monomers and cause oligomerization and apoptosome machine formation ...(2). ...
13
Heat shock pretreatment improves mesenchymal stem cell viability by heat shock proteins and autophagy to prevent cisplatin-induced granulosa cell apoptosis
... °C, 1 h), which were sustained in an extended period of ...intrinsic apoptotic path- way through binding the caspase-recruitment domain of apoptotic protease-activating ...
12
Aberrant Methylation of APAF-1 Gene in Acute Myeloid Leukemia Patients
... methylated APAF-1 and DAPK-1 tumor suppressor genes uncover clear cell renal cell carcinomas with aggressive ...absent apoptotic protease activating factor-1 ...
7
Decreased expression of APAF-1 and increased expression of cathepsin B in invasive pituitary adenoma
... Purpose: Apoptotic protease-activating factor-1 (APAF-1) and cathepsin B are important functional proteins in apoptosis; the former is involved in the intrinsic ...
10
Analysis of the expression of PHTF1 and related genes in acute lymphoblastic leukemia
... transcription factor, the PHTF1 gene is mainly involved in biological processes such as DNA- dependent tran- scription and the regulation of biological ...necrosis factor receptor-1 (TNFR1), and ...
11
HDAC inhibition activates the apoptosome via Apaf1 upregulation in hepatocellular carcinoma
... identified apoptotic protease-activating factor 1 (Apaf1) to be significantly upregulated after HDAC inhibition (HLE siRNA#1/siRNA#2 p < ...
6
Exosomes in tumor microenvironment: novel transporters and biomarkers
... APAF1: apoptotic protease activating factor‑1; AR: androgen receptor; CAV1: caveolin‑1; DC: dendritic cells; Dex: dendritic cell‑derived exosomes; ECM: extracellular matrix; ...
9
The role of death-associated protein 3 in apoptosis, anoikis and human cancer
... inducing factor; AKT/PKB: Protein kinase B; APAF1: Apoptotic protease activating factor 1; BAX: BCL2 associated X protein; BCL2: B-cell lymphoma 2 protein; BID: BH3 interacting ...
10
Krill oil extract suppresses the proliferation of colorectal cancer cells through activation of caspase 3/9
... kinase; APAF-1: apoptotic protease activating factor; ATCC: American Tissue Culture Collection; Bak: pro- apoptotic Bcl-2 proteins; Bcl-2: B cell lymphoma protein; COX-2: ...
15
Aberrant localization of apoptosis protease activating factor-1 in lipid raft sub-domains of diffuse large B cell lymphomas
... In order to understand the precise mechanism underlying the resistance of human B cell lymphomas to drug-induced apoptosis, we obtained biopsies from patients with a variety of lymphomas and performed magnetic separation ...
12
More than just inflammation: Ureaplasma species induce apoptosis in human brain microvascular endothelial cells
... APAF: Apoptotic protease activating factor; ATCC: American Tissue Culture Collection; BAK: BCL2 homologous antagonist/killer; BAX: BCL2-associated X apoptosis regulator; BBB: ...
13
Immune cell subset differentiation and tissue inflammation
... (ox-PL) 1-palmitoyl-2arachi- donoyl-sn-glycero-3-phosphorylcholine treatment, which upregulate the expression of oxygenase-1 (HO-1) and thioredoxin reductase 1 (Txnrd1) ...
22
The ubiquitin–proteasome system and signal transduction pathways regulating Epithelial Mesenchymal transition of cancer
... type 1, 2 and 3 [3]. The starting point of type 1 EMT is, thus, epithelial progenitors in the embryo that lose conduct with their initial site and move to become a different structure with different ...
13
Regulation of factor XIa activity by platelets and alpha 1 protease inhibitor
... platelets, Factor XIa, alpha 1- protease inhibitor and Factor IX ...of Factor XIa, and to protect Factor XIa from inactivation in the presence of alpha 1-protease ...
10
Dysfunction of various organelles provokes multiple cell death after quantum dot exposure
... ATF4, activating transcription factor 4; ATF6, activating transcription factor 6; Bak, Bcl-2 antagonist/killer 1; Bax, Bcl-2-associated X protein; Bcl-2, B-cell lymphoma-2; Bcl-xl, ...
14
A factor X activating cysteine protease from malignant tissue
... diisopropylfluorophosphate with CuSO4 and imidazole virtually eliminated inhibition of thrombin, but cancer procoagulant inhibition remained complete, suggesting that cancer procoagulant was inhibited by the undefined ...
8
Kinetic Folding Studies of Apaf-1 CARD and Procaspase-3
... parameters associated with the transition. By comparing these values to those determined from equilibrium experiments, additional information about the burst phase species is acquired. For example, folding studies of ...
259
Activation of factor VII activating protease in human inflammation: a sensor for cell death
... In purified systems C1-inh and AP were reported to be the main inhibitors of activated FSAP [11,16,17]. In plasma only C1-inh was demonstrated to be an inhibitor of FSAP [16]. Serpins form covalent complexes with their ...
10
The hemostatic profile of recombinant activated factor VII. Can low concentrations stop bleeding in off-label indications?
... The rFVIIa concentrations used in these in vitro exper- iments are comparable with the predicted concentrations of rFVIIa achieved in plasma by the administration of high (approximately 200 μg/kg), moderate (104 μg/kg), ...
7
Evolution of the initiating enzymes of the complement system
... lectins, factor B has also been identified from ascidian ...[23]. Factor B is a key component of the mammalian alternative pathway, where it acts as a catalytic subunit of the alternative path- ways C3 ...
5