Aromatase inhibitor
Role of Aromatase Inhibitor in Endometriosis
... of aromatase inhibitor has brought a revolution to the treatment for ...estrogen, aromatase inhibitor is able to suppress the estrogen level without depleting the estrogen ...receptors. ...
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Tracking evolution of aromatase inhibitor resistance with circulating tumour DNA analysis in metastatic breast cancer.
... Selection of resistance mutations may play a major role in the development of resistance to therapy. Many examples are described, such as KRAS mutations emerging in colorectal cancer treated with anti-epidermal growth ...
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Growth Hormone With Aromatase Inhibitor May Improve Height in CYP11B1 Congenital Adrenal Hyperplasia
... third-generation aromatase inhibitor, anastrozole, in an attempt to optimize his ...an aromatase inhibitor in combination with growth hormone to optimize height in 11 β -hydroxylase-deficient ...
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Changes in expression of oestrogen regulated and proliferation genes with neoadjuvant treatment highlight heterogeneity of clinical resistance to the aromatase inhibitor, letrozole
... Endocrine therapy is a major treatment modality for breast cancer but its utility is limited by both primary and acquired resistance [1-3]. Current selection for the treatment is based on presence of oestrogen receptors ...
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Aromatase inhibitor treatment with an intravaginal device and its effect on pre-ovulatory ovarian follicles in a bovine model
... Non-steroidal aromatase inhibitors prevent the body from producing its own ...steroidal aromatase inhibitor, is used as an adjuvant treatment for hormone-responsive breast cancer in post- menopausal ...
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Sex reversed chicks (Gallus domesticus) hatched from eggs treated with aromatase inhibitor YM511
... the aromatase inhibitor ...+ aromatase inhibitor (YM511, 1 mg/egg, 83 eggs injected, treated group) and then incubated under standard ...
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Opposite-directional sex change in functional female protandrous anemonefish, Amphiprion clarkii: effect of aromatase inhibitor on the ovarian tissue
... Introduction: The anemonefish, Amphiprion clarkii, is a protandrous hermaphrodite. Under appropriate social conditions, male fish can become female. Previous studies indicated that estrogens are important regulators of ...
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The impact of an exercise program on quality of life in older breast cancer survivors undergoing aromatase inhibitor therapy: a randomized controlled trial
... the aromatase inhibitor-induced musculoskeletal syndrome, a reduced risk of breast cancer recurrence, and im- proved breast cancer-specific and all-cause mortality ...
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Managing arthralgia in a postmenopausal woman taking an aromatase inhibitor for hormone-sensitive early breast cancer: a case study
... between aromatase inhibitors in order to relieve symptoms of ...managing aromatase inhibitor-associated arthralgia are key to deriving maximal clinical benefit from AI ...one aromatase ...
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Nonhypoxic regulation and role of hypoxia inducible factor 1 in aromatase inhibitor resistant breast cancer
... the aromatase gene by the laboratory of ...AI: aromatase inhibitor; Akt: also known as protein kinase B; ANOVA: analysis of variance; BCRP: breast cancer resistance protein; CDT: charcoal-dextran ...
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Circulating ESR1 mutations at the end of aromatase inhibitor adjuvant treatment and after relapse in breast cancer patients
... Background: Detection of circulating ESR1 mutations is associated with acquired resistance to aromatase inhibitor (AI) in metastatic breast cancer. Until now, the presence of circulating ESR1 mutations at ...
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Bilateral De Quervain Syndrome after Aromatase Inhibitor Administration: A Case Report and Review of the Literature
... with aromatase inhibitor-associated tendinopathy, such as ESR, CRP, RF, antinuclear antibody, anti-double-stranded DNA antibody, and anticyclic citrullinated peptide antibody, have not identify a ...
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The immunoexpression of androgen receptor, estrogen receptors alpha and beta, vanilloid type 1 receptor and cytochrome p450 aromatase in rats testis chronically treated with letrozole, an aromatase inhibitor
... P450 aromatase (P450arom), as well as apoptosis of cells in testis of adult rats chronically treated with letrozole (LT), a non-ste- roidal aromatase inhibitor, for 6 ...
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Vertebral bone marrow fat fraction changes in postmenopausal women with breast cancer receiving combined aromatase inhibitor and bisphosphonate therapy
... Aromatase inhibitor (AI) therapy is a standard treatment component for estrogen receptor positive breast cancer in postmenopausal women [18–20]. By reducing estrogen levels, it inhibits tumor cell growth. ...
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Association of functional polymorphisms in CYP19A1 with aromatase inhibitor associated arthralgia in breast cancer survivors
... The Wellness After Breast Cancer (WABC) Study is a cross-sectional study conducted between March 2008 and July 2009 at the Rowan Breast Cancer Center of the Abramson Cancer Center of the University of Pennsylva- nia ...
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Growth Hormone With Aromatase Inhibitor May Improve Height in CYP11B1 Congenital Adrenal Hyperplasia
... third-generation aromatase inhibitor, anastrozole, in an attempt to optimize his ...an aromatase inhibitor in combination with growth hormone to optimize height in 11 β -hydroxylase-deficient ...
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Effects of the Aromatase Inhibitor, Letrozol, on Levels of Serum 17β-Estradiol (E2) And Enzymes in Rainbow Trout (Oncorhynchus Mykiss Walbaum) Females
... In the present study, changes of values of serum 17ß-estradiol (E2), Asparate amino teransferase (AST), Alanine amino transferase (ALT) and Lactate dehydrogenase (LDH) following intraperitoneal (i.p) injection with the ...
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Understanding the mechanisms of aromatase inhibitor resistance
... the aromatase gene and may have functional infl uences on the interaction between the enzyme protein, its substrate and inhibitors ...the aromatase CYP19 ...the aromatase inhibitor letro- zole, ...
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Serum estradiol should be monitored not only during the peri menopausal period but also the post menopausal period at the time of aromatase inhibitor administration
... Background: Aromatase inhibitor (AI) therapy is being extensively used as postoperative adjuvant therapy in patients with hormone receptor-positive postmenopausal breast ...
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Durable complete remission with aromatase inhibitor therapy in a patient with metastatic uterine carcinosarcoma with poor performance status and coagulation disorders: a case report
... non-steroidal aromatase inhibitor therapy with letrozole was ...initiating aromatase inhibitor therapy, she underwent a radical hysterectomy and the pathological report showed a complete ...
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