Aromatase inhibitors-dosage and adverse effects
Do aromatase inhibitors have adverse effects on cognitive function?
... Th ose results are discussed in the relevant section of ‘Data from non-randomized comparisons’ below. Th e IBIS II and TEAM studies provide good evidence that there is no moderate or large adverse eff ect of ...
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Aromatase inhibitors in men: effects and therapeutic options
... release. Aromatase inhi- bitors, mostly combined with agonists of gonadotro- phin-releasing hormone proved effective for the prevention of premature epiphysial closure in boys with pubertas praecox of various ...
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SIDE EFFECTS REVISITED: Women s Experiences With Aromatase Inhibitors
... * Th e results have been written with the layperson in mind, so all signifi cant tests have been omitted from the text and are listed as footnotes. Chi square (Χ 2 ) tests were done using the following web site: ...
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Bone loss and the aromatase inhibitors
... androgenic effects of exeme- stane, it is likely that the profound suppression of circulating oestrogens caused by the potent inhibition of aromatase will over- ride this and, as with the nonsteroidal ...
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Aromatase inhibitors in post-menopausal endometriosis
... Aromatase inhibitors (AIs) represent one of the most recently used drugs for postmenopausal endometriosis. Clinical data for the use of (AIs) in postmenopausal patients is scarce. Up to date only 5 case ...
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Aromatase Inhibitors. in the Treatment of. Breast Cancer
... severe adverse reactions include deep venous thromboses (including pulmonary emboli), ischemic cerebrovascular events and cardiovascular ...side effects related to the third generation aromatase ...
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Use of aromatase inhibitors in practice of gynecology
... of aromatase inhibitors in the follicular phase, follicular growth is accompanied by increased estrogen ...cause aromatase inhibitors do not deplete estrogen recep- tors in the ...Initially, ...
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The emerging use of aromatase inhibitors for endometriosis treatment
... expresses aromatase, an enzyme critical for estrogen production, emphasis has been placed upon the use of aromatase inhibitors for the treatment of endometriosis and its associated ...of ...
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Clinical utilities of aromatase inhibitors in breast cancer
... Keywords: aromatase inhibitor, endocrine therapy, breast cancer Introduction aromatase is an enzyme that is a member of the cytochrome P450 ...15, aromatase is encoded in CYP19A1 gene. 1,2 ...
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Potential role of aromatase inhibitors in the treatment of endometriosis
... Side effects of aromatase inhibitors The side effects associated with the use of third-generation AIs (letrozole, anastrozole) are mostly hypoestrogenic in nature, and include vaginal dryness, ...
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Bicalutamide and Third-Generation Aromatase Inhibitors in Testotoxicosis
... CONCLUSIONS These data support the efficacy of third-generation AIs and the antian- drogen agent bicalutamide for the treatment of FMPP. This combination therapy provides a more convenient once-daily dosing regimen, ...
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Effects of steroidal and nonsteroidal aromatase inhibitors on markers of bone turnover in healthy postmenopausal women
... Conclusion In recent years, use of the third-generation AIs anastrozole, letrozole, and exemestane has resulted in improved clinical outcomes for postmenopausal patients with early breast can- cer. However, because of ...
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The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment
... deleterious effects of the supra- physiological estrogen levels attained during routine con- trolled ovarian ...tion aromatase inhibitors in ovarian ...
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EFFECTS OF TAMOXIFEN AND AROMATASE INHIBITORS ON ENDOMETRIUM IN BREAST CANCER PATIENTS AT ZAGAZIG UNIVERSITY HOSPITALS.
... Objective: To investigate the effect of endometrial abnormalities in breast cancer patients treated with Tamoxifen (group I), Aromatase inhibitors (group II) or No treatment (group III) .To determine the ...
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AROMATASE INHIBITORS: A NEW HOPE FOR BREAST CANCER PATIENTS
... ISSN: 0975-8232 Available online on www.ijpsr.com 28 INTRODUCTION: Estrogens, female sex hormones are involved in development and maintenance of female sexual organs, reproductive cycle, reproduction, various ...
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Aromatase inhibitors for subfertile women with polycystic ovary syndrome
... CC administered orally, but due to their short half-life elimina- tion time of 48 hours there are fewer adverse effects on oestrogen target tissues such as endometrium and cervix compared to CC Baruah 2009; ...
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Emerging Role of Aromatase Inhibitors in the Treatment of Breast Cancer
... for aromatase inhibition, since levels of other cytochrome P450 synthesis-dependent hormones, including cortisol, aldosterone, and thyroid hormone, could be ...competitive inhibitors of ...for ...
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Potential adverse effects of long term use of Proton Pump Inhibitors.
... anti-inflammatory effects. 35 To understand the effects of PPIs on CDAD, attention has focused on the survival of acid-resistant spores, delayed gastric emptying, possible effects of bile salts, and ...
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The Efficacy of 3rd Generation Aromatase Inhibitors in Breast Cancer Chemoprevention
... Conclusion: Third generation AIs, such as anastrozole and exemestane, are very effective at reducing the incidence of invasive breast cancer, ductal carcinoma in situ, and certain tumors in high-risk postmenopausal ...
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Understanding Aromatase: A Mechanistic Basis for Drug Interactions and New Inhibitors
... side effects that result in non-compliance and poor quality of life of breast cancer ...tolerable aromatase inhibitors with improved therapeutic ...2008). Aromatase inhibitors are also ...
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