artemisinin derivatives
Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer
... of artemisinin is a sesquiterpene lactone with potent anti-malarial ...of artemisinin, a series of artemisinin derivatives were synthesized and proved to possess better bioactivity or ...
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The Safety of Artemisinin Derivatives for the Treatment of Malaria in the 2nd or 3rd Trimester of Pregnancy: A Systematic Review and Meta-Analysis
... treatment. Artemisinin derivatives are the most effec- tive antimalarials, but are associated with teratogenic and embryotoxic effects in animal models when used in early ...as artemisinin-based ...
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Delayed anemia assessment in patients treated with oral artemisinin derivatives for uncomplicated malaria: a pooled analysis of clinical trials data from Mali
... 3). Artemisinin derivatives have been shown to induce reticu- locytopaenia in preclinical studies, potentially by suppress- ing the erythroblasts ...oral artemisinin derivatives therapy may ...
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Are k13 and plasmepsin II genes, involved in Plasmodium falciparum resistance to artemisinin derivatives and piperaquine in Southeast Asia, reliable to monitor resistance surveillance in Africa?
... According to the WHO, the resistance to dihydroar- temisinin–piperaquine has not yet emerged in Africa. There is currently no evidence of failing efficacy of dihy- droartemisinin–piperaquine in Africa. The latest pub- ...
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Blocking malaria transmission to Anopheles mosquitoes using artemisinin derivatives and primaquine: a systematic review and meta analysis
... temisinin derivatives from malaria patients to Anopheles gambiae, a major malaria vector in Africa ...of artemisinin derivatives and prima- ...of artemisinin deriv- atives and primaquine on ...
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Artemisinin derivatives versus quinine in treating severe malaria in children: a systematic review
... on artemisinin derivatives [8-19]; a group of drugs with no known Plasmodium falci- parum resistance and which act faster than all known malaria drugs ...
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EVALUATION OF EFFICACY AND SAFETY OF ARTEMISININ DERIVATIVES FOR TREATMENT OF SEVERE MALARIA: A META-ANALYSIS APPROACH
... Artemisinin derivatives also shorten the parasite clearance time by around ...the artemisinin derivatives compared with ...that artemisinin or its derivatives showed a ...
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Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta analysis
... In the mid-1980s, the WHO recommended schistoso- miasis control strategies for humans by focusing on the large-scale population-based and repeated chemother- apy, which is still the key strategy today [10]. The che- ...
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First trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia: A meta analysis of observational studies
... trimester quinine or artemisinin treatment have been documented prospectively with a known pregnancy outcome. In total, this has taken 32 years of cumulative and collective efforts since the introduction of ...
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← Return to Article Details Artemisia annua (Sweet Annie), Other Artemisia Species, Artemisinin, Artemisinin Derivatives, and Malaria
... that artemisinin is the only relevant compound in the whole tea, then these pharmaco- kinetic studies can perhaps only be interpreted as providing insufficient levels of artemisinin for clinical efficacy as ...
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Optimal sampling designs for estimation of Plasmodium falciparum clearance rates in patients treated with artemisinin derivatives
... whether the slow clearing phenotype is present and to de- tect early changes in parasite clearance. Figure 5 shows that for HL ≥ 5 hours, the proportion of D3 positive pa- tients provides a clear indication of diminished ...
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Artemisinin, a Potential Antimalarial Drug: Current Status
... of artemisinin derivatives against Fe(II) based on an experimental observation of a special C-12 nitrogen-substituted derivative ...of artemisinin may be caused by (1) the interaction of the intact ...
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Genetic diversity and drug resistance surveillance of Plasmodium falciparum for malaria elimination: is there an ideal tool for resource limited sub Saharan Africa?
... of artemisinin-based combination therapy (ACT), which are the recommended drugs for the treatment of adults and children with uncomplicated ...combines artemisinin derivatives and other long-acting ...
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Malaria: severe, life-threatening
... Compared with rectal artemisinin derivatives Quinine seems to be as effective as rectal artemether and artemisinin at reducing time to recovery of coma in people with severe malaria (hig[r] ...
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Stability Indicating High-Performance Liquid Chromatography Method for the Estimation of Artemether in Capsule Dosage Forms
... Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: Mechanism(s) of action. Basco LK, Le Bras J. In vitro Activity of Artemisinin Derivatives Against African Isol[r] ...
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BETWEEN ARTEMISININ AND DERIVATIVES WITH NEURAMINIDASE: A DOCKING STUDY INSIGHT
... between artemisinin and derivatives with anti-influenza properties toward NA ...potent artemisinin derivatives as NAI with molecular docking ...seven artemisinin derivatives as ...
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Were medicine quality and pharmaceutical management contributing factors in diminishing artemisinin efficacy in Guyana and Suriname?
... [12]). Artemisinin derivatives com- prised four of the anti-malarials collected in Brazil and 92 of those collected in ...were artemisinin-containing ...
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COMBINATION THERAPY AND ITS IMPLICATION ON CLINICAL EFFICACY OF ARTEMISININS REVIEW
... of artemisinin derivatives: Malaria is a (eukaryotic) protozoan parasite of red blood cells that may reach burdens as high as 10 13 in the blood of the human host, although most symptomatic infections are ...
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Malaria profiles and challenges in artemisinin resistance containment in Myanmar
... of artemisinin resistance contain- ment projects to prevent national, regional, and global spread of artemisinin drug resistance, there have been few studies that evaluated the coverage of key contain- ment ...
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Artemisinin Reduces Lipid Accumulation in Hepatocytes by Inhibition of CD36 Expression
... seeded in 48well plates and preincubated with RMPI 1640 containing 10% of FBS for 12 h. The cells were then exposed to different concentration of artemisinin for 12 h and then treated with 0.5 mM or 1.0 mM oleic ...
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