Artocarpus hirsutus

Top PDF Artocarpus hirsutus:

Evaluation Of In Vitro Antioxidant Potential, Anti-inflammatory Activity And Melanogenesis Inhibition Of Artocarpus Hirsutus Lam. Extracts

Evaluation Of In Vitro Antioxidant Potential, Anti-inflammatory Activity And Melanogenesis Inhibition Of Artocarpus Hirsutus Lam. Extracts

Artocarpus hirsutus Lam. (Moraceae) is a perennial tree from the genus Artocarpus. It is endemic to Western Ghats of India and grows mainly in southern states of India [1], [2]. Artocarpus species such as A. heterophyllus (Jack fruit), A. altilis (bread fruit) and A. hirsutus (Monkey Jack) [3] produce edible fruits possessing good nutritional value and are in use as traditional medicine in India and South East Asian countries for the treatment of inflammation, malarial fever, ulcer, diarrhea, liver tonic, hypertension and diabetes. The pulp and seeds produced by A. heterophyllus are used as traditional herbal tonic; whereas roots of this species assist to control diarrhea and diabetes. The leaves of A. lakoocha protects against liver disorders, hypertension and diabetes [4]. Similarly, the rarely studied species of the genus, A. hirsutus Lam. [4], [5], [6], [7], [8], [9], [10], effectively relieves ulcers, diarrhea and soothing pimples [7]. It is also reported that the extracts of Artocarpus species have good cosmetic application [11]. Melanin pigments, produced by melanocytes, prevent skin damage apart from improving the skin colour. Abnormal hyper pigmentation causes melasma, post inflammatory melanoderma freckles and lentigines [12], [13], while hypopigmentation is associated with UV sensitivity and predisposition to skin cancer.
Show more

8 Read more

Preliminary phytochemical screening and hepatoprotective activity of methanol extract of  Artocarpus hirsutus  leaves.

Preliminary phytochemical screening and hepatoprotective activity of methanol extract of Artocarpus hirsutus leaves.

Liver is the very important and massive visceral organ found into substantial portion of abdomen, which plays important role in regulating different physiological process in body. It involved in many vital functions like metabolism, secretion, storage, and detoxification and synthesizes useful principles. It also removes toxic materials from blood [1]. Liver diseases are mainly caused by excess consumption of alcohol, autoimmune disorders, toxic chemicals and infections [2]. It has become one of the major causes of mortality and morbidity all over the world. Many chemicals and drugs cause different types of liver toxicity that are highly variable. All over the world, the researchers have been in continuous search for some effective remedy for restoring the functions. The plant kingdom is indubitably one of the valuable sources of new medicinal agents. Numerous herbs and plants play a major role in the management of different liver disorders [3]. Artocarpus hirsutus belongs to the family Moraceae and this DOI:10.5138/09750185.1900
Show more

5 Read more

PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF ETHANOLIC EXTRACT OF THE ARTOCARPUS HIRSUTUS LAM  LEAVES

PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF ETHANOLIC EXTRACT OF THE ARTOCARPUS HIRSUTUS LAM LEAVES

Effect of EEAH on Liver Parameters: The serum levels of liver enzymes like SGOT, SGPT, ALT, urea, creatinine are found to increase in the streptozotocin-induced diabetic rats. But on treatment with the standard glibenclamide, the value of these enzymes found reduced. On treatment with an ethanolic extract of Artocarpus hirsutus the level of the enzyme reduced to a marked level significantly (P<0.01) to 400 mg extract when compared to vehicle control. The value of total proteins was found to decrease in streptozotocin-induced diabetic group (II) on comparing with normal control. On treatment with glibenclamide, the protein levels found to increase significantly (P<0.01). Similarly, the treatment with the ethanolic extract improves the level of protein in the test group (IV and V).
Show more

9 Read more

IN VITRO ANTI ARTHRITIC ACTIVITY ON TENDER LEAVES OF ARTOCARPUS HIRSUTUS LAM

IN VITRO ANTI ARTHRITIC ACTIVITY ON TENDER LEAVES OF ARTOCARPUS HIRSUTUS LAM

In the present study, the qualitative phytochemical analysis showed the presence of flavonoids and other active constituents in Artocarpus hirsutus lam. From the results, it may be concluded that tender leaves of Artocarpus hirsutus lam possess significant anti-arthritic activity. The in vitro anti-arthritic effect of the extract was evaluated against denaturation of bovine albumin. The present findings exhibited a concentration dependent inhibition of protein (albumin) denaturation by the extract. Phytoconstituents such as steroids, terpenoids, flavanoids, phenols and tannins are explored as in vitro anti-arthritic agents from various medicinal plants. The activity may be due to the presence of Steroids, flavanoids, saponin and coumarin glycosides, and terpenoids. Our future aim is to isolate the chemical constituents responsible for that activity. Hence it could be beneficial for further work as active anti- arthritic agent.
Show more

7 Read more

Pharmacological Evaluation of Methanolic Extract of Leaves of Artocarpus Hirsutus Lam.

Pharmacological Evaluation of Methanolic Extract of Leaves of Artocarpus Hirsutus Lam.

Pharmacological evaluation of methanolic extract of Artocarpus hirsutus Lam.was carried out in the Department of Pharmacology, Periyar College of Pharmaceutical Sciences, Tiruchirappalli, Tamilnadu, India. Animal facility of this institute is approved by CPCSEA, NewDelhi. The experimental protocols for the antiulcer,anticonvulsant and antidiarrhoeal activities have been approved by the Insititutional Animal Ethics Committee (IAEC) and conducted according to the guidelines of Indian National Sciences Academy for the use and care of experimental animals.IAEC approved this proposal with approval number PCP/IAEC/002/2013. The animals were maintained at a well ventilated, temperature controlled 30 o C±1 o C animal room for 7days prior to the experimental period and provided with food and water ad libitum. The animals were acclimatized to laboratory conditions before the test. Each animal was used only once.
Show more

127 Read more

PHARMACOGNOSTICAL AND ANALYTICAL ANALYSIS OF ARTOCARPUS HIRSUTUS LAM.-A FOLK PLANT .......

PHARMACOGNOSTICAL AND ANALYTICAL ANALYSIS OF ARTOCARPUS HIRSUTUS LAM.-A FOLK PLANT .......

Fruits of Artocarpus hirsutus Lam. were collected from UJrakala, Karkala, and Hebri of Udupi district. The authenticity of fruits was confirmed by experts at SDM Centre for Re- search in Ayurveda and Allied Sciences, Udupi with the help of Pharmacognosist. Botanical characters were also compared with various floras. Thereafter, seeds were taken out from the fruit and were washed properly. Seed were sun dried and were used for further evaluation. PRESERVATION OF SAMPLE

7 Read more

ABA production in response to the desiccation of recalcitrant embryos of Artocarpus heterophyllus LAM  and Artocarpus hirsutus LAM

ABA production in response to the desiccation of recalcitrant embryos of Artocarpus heterophyllus LAM and Artocarpus hirsutus LAM

The loss of cell turgor or cell membrane perturbation accompanied by dehydration is considered as a signal for ABA accumulation and subsequent desiccation tolerance (Ackerson RC., 1983; Milborrow BV., 1973; Quarrie SA., 1984; Zeevaart JAD., 1980). The studied species showed tolerance to mild desiccation. Both cultivars of Artocarpus heterophyllus could tolerate desiccation up to 55% even under low level of ABA. However, Artocarpus hirsutus could tolerate desiccation up to 31% even under extremely low level of ABA. This indicates that ABA is not the sole factor responsible for providing tolerance to desiccation. Further research is required to understand the molecular mechanism behind the sensitivity of recalcitrant seeds towards desiccation.
Show more

5 Read more

PHYTOCHEMICAL SCREENING OF ARTOCARPUS HIRSUTUS AND ITS ANTIMICROBIAL POTENTIAL

PHYTOCHEMICAL SCREENING OF ARTOCARPUS HIRSUTUS AND ITS ANTIMICROBIAL POTENTIAL

Artocarpus hirsutus belongs to the Moraceae family and consists of 50 different species. It is called Hebbalasu in Kannada; Vadahar in Hindi; Lakucha, Dahu, Adahu, Iravatam, and Panasah in Sanskrit; Ranpanas and Pachpanas in Konkani; Anhili, Ayani-maram, Ayani, Anjili, and Ayiniplavu in Malayalam; Kattupula, Aiyinipala, Kurangupala, and peipala in Tamil; Pejakai in Tulu; and Adavipanasa in Telugu. A. hirsutus is a tropical evergreen tree species that is native to India (Karnataka, Kerala, Maharashtra, and Tamil Nadu) [11]. They are widely acknowledged as a rich source of bioactive secondary metabolites such as flavonoids, stilbenes, triterpenoids, and xanthones [12].
Show more

5 Read more

A comparative study of air pollution induced stress tolerance of selected tree species in a disturbed and undisturbed plant community

A comparative study of air pollution induced stress tolerance of selected tree species in a disturbed and undisturbed plant community

Based on the predominance of occurrence in the disturbed site, 10 tree species selected for the present study were Artocarpus hirsutus Lam., Cinnamomum iners Blume., Garcinia gummigutta (L) Roxb., Hevea braziliensis Willd., Mangifera indica Linn., Polyalthia longifolia Sonn., Psidium guajava Linn., Syzygium samarangense Blume., Syzygium samarangense Blume. and Tectona grandis Linn. Leaf samples collected from the selected trees found in disturbed and undisturbed site were subjected to estimation of various biochemical parameters such as ascorbic acid, total chlorophyll content, leaf extract pH and relative water content. The results obtained from the biochemical estimation are discussed here below. Ascorbic acid which is known as stress hormone, was found to be higher in the tree species of disturbed site as compared to the tree species of the undisturbed site. The ascorbic acid content among of the trees of undisturbed area varied between 5.18 mg/ml to 8.28mg/ml, while of the undisturbed area ranged between 3.89 to 7.15 mg/ml. Among all the selected trees, high levels of ascorbic acid content was observed in Tectona grandis Linn. of disturbed area and lowest level was found in Polyalthia longifolia Sonn. of undisturbed site (Table 1). Also the maximum increase in the ascorbic acid content from undisturbed area to disturbed area was seen in Garcinia gummigutta (L) Roxb (2.33 mg/ml). The total chlorophyll content of Polyalthia longifolia Sonn of undisturbed area (0.76 mg/g) as well as disturbed area was found to be highest as compared to all other selected trees (Figure 3). In all the selected trees, total chlorophyll content was found to be much lower in disturbed site as compared to undisturbed site.
Show more

6 Read more

“Phytopharmacognostical Evaluation of Leaf of Cocculus hirsutus” by Jethva Khushboo, Bhatt Dhara, Dhru Bhavita, Patel Sonal, Zaveri Maitreyi, India.

“Phytopharmacognostical Evaluation of Leaf of Cocculus hirsutus” by Jethva Khushboo, Bhatt Dhara, Dhru Bhavita, Patel Sonal, Zaveri Maitreyi, India.

Ethanomedicinal plant Cocculus hirsutus belonging to the family Menispermeace commonly known as Vevdi or vevati in Gujarat, India. Pharmacognostical evaluation including examination of morphological and microscopical characters, determination of quality control parameters such as ash values, extractive values, moisture content, and foreign matter were carried out. Phytochemical screening including qualitative chemical examinations was also carried out. Hence, the present attempt was undertaken to investigate the Phytopharmacognostical studies of leaf of Cocculus hirsutus. The study revealed the presence lamina and midrib regions. Surface of leaf consists of long and short unicellular trichomes. Anomocytic stomatas were found on lower epidermis only. Midrib exhibited crescent (semi-circular) shaped vascular bundle enclosed by sclerenchymatous bundle sheath. Phytochemical screening of the Cocculus hirsutus showed the presence of phytoconstituents like flavonoids, phenolics, saponins and steroids. Keywords: Cocculus hirsutus, pharmacognostical screening, Phytochemical evaluation, vevdi
Show more

6 Read more

 EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES

 EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES

The human red blood cell membrane stabilization method was used for this study. The blood was collected from healthy human volunteer who was not taken any NSAID’s for 2 weeks prior to the experiment and mixed with equal volume of Alsever solution (2% Dextrose, 0.8%Sodium citrate, 0.5% Citric acid & 0.42% Nacl) and centrifuged at 3,000 rpm for 20 min. The Packed cells were washed with Isosaline and a 10% suspension was made. Various concentrations of methanolic extract of Cocculus hirsutus were prepared (100, 200 mcg/ml) using with CMC and to each concentration 1ml of phosphate buffer, 2ml of hypo saline & 0.5ml of HRBC suspension were added. It is incubated at 37°c for 30 min and centrifuged at 3,000 rpm for 20 min. The hemoglobin content of the supernatant solution was estimated spectrometrically at 560nm. Diclofenac (mcg/ml) was used as reference standard and a control was prepared omitting the extracts (Rajendran Vadivu et al., 2008).
Show more

5 Read more

HEPATOPROTECTIVE EFFECT OF COCCULUS HIRSUTUS LINN. AGAINST ETHANOL- INDUCED LIVER DAMAGE IN ALBINO WISTAR RATS

HEPATOPROTECTIVE EFFECT OF COCCULUS HIRSUTUS LINN. AGAINST ETHANOL- INDUCED LIVER DAMAGE IN ALBINO WISTAR RATS

methanolic extract of C. hirsutus and showed dose dependant activity. At the dose of 400mg/kg extract showed comparable activity with the standard drug silymarin. Histopathological studies, showed ethanol to produce extensive vascular degenerative changes and centrilobular necrosis in hepatocytes. Treatment with silymarin and methanolic extract of C. hirsutus produced mild degenerative changes and absence of centrilobular necrosis when compared with control (fig. 1). All these results indicate a hepatoprotective potential of C. hirsutus showed a dose dependent activity which was confirmed by Histopathological examination.
Show more

8 Read more

Taxonomy and evolution of endemic New Zealand broad-nosed weevils (Coleoptera: Curculionidae: Entiminae)

Taxonomy and evolution of endemic New Zealand broad-nosed weevils (Coleoptera: Curculionidae: Entiminae)

Chalepistes egens Chalepistes hirsutus Chalepistes instabilis Chalepistes instabilis Chalepistes inundans Chalepistes inundans Chalepistes inundans Chalepistes inundans Chalepistes inund[r]

302 Read more

Phytochemicals and bioactivities of Artocarpus Anisophylluss MIQ

Phytochemicals and bioactivities of Artocarpus Anisophylluss MIQ

Artocarpus anisophyllus Miq. is one of Malaysian rare Artocarpus species. A. anisophyllus Miq. is locally known as “keledang babi” or “mentawa”. It is a mid-canopy tree, stem with white sap and hairy. It has leaflet penni-veined and glabrous which is large and small in regular order. A. anisophyllus can be found in the lowland of Negeri Sembilan, Johor, Sumatera and Borneo. The barks of A. anisophyllus are locally used as rope for backpacks, whereas the leaves can be used against boils and itch by burning and mixed with coconut oil [6].

39 Read more

Chemical and paf activity of several Malaysian artocarpus

Chemical and paf activity of several Malaysian artocarpus

anti-tumor promoter based on the similarity of the structure with morusin (4) which was isolated from the root bark of Morus alba L.. The latter compound had been reported as an anti-tumor promoter in a two-stage carcinogenesis experiment with teleocidin [5, 6]. Both compounds have an isoprenoid moiety at the C-3 position. The difference is in the B ring where morusin (4) has a structure bearing a 2′,4′-dioxygenated pattern while artonin E (1) has a structure bearing a 2′,4′,5′-trioxygenated pattern. Thus, the inhibitory effect of the Artocarpus flavonoids on tumor-necrocis factor-α (TNF-α) release stimulated by okadaic acid using BALB/3T3 cells has been examined [7, 8]. All the tested compounds inhibited the TNF-α release stimulated by okadaic acid at suitable lower concentration. Artonin E (1) was found to be the most potent inhibitor. Heterophyllin (5) and artobiloxanthone (6) inhibited stronger than cycloheterophyllin (7), cycloartobiloxanthone (8), and morusin (4). The compounds which exhibited strong activity have three hydroxyl groups in the B ring. This characteristic feature might be one of the important factors for their biological activity.
Show more

18 Read more

Comparative study of methanolic and aqueous extracts of Cocculus hirsutus leaves on specific and non specific immune responses

Comparative study of methanolic and aqueous extracts of Cocculus hirsutus leaves on specific and non specific immune responses

Methanolic extract of Cocculus hirsutus with the dose of 200 and 400 mg/kg increased paw volume as dose dependent manner after 24 hrs, paw volume in this group were increased by 45.83% and 70.83% i.e. most significantly (p<0.01) enhanced the delayed type of hypersensitive activity as compared to control (Sensitized) were observed at 24 hours after SRBC injection in the footpad. Whereas at dose 500 mg/kg b.w, aqueous extract of Cocculus hirsutus increased less significantly (p<0.05) in food pad thickness after 24 hours but at the dose 250 mg/kg b.w dose not show any significant result.
Show more

6 Read more

Phytochemicals and biological activities of artocarpus fulvicortex jarrett

Phytochemicals and biological activities of artocarpus fulvicortex jarrett

Phytochemical studies of the leaves and barks of Artocarpus fulvicortex Jarrett have been carried out. Cold extraction method was applied to obtain the crude extracts. Twelve compounds, comprising of chalcones, flavones, and triterpenes were successfully isolated from this plant. The structures of these pure compounds were determined on the basis of spectral studies including nuclear magnetic resonance, infrared, ultraviolet spectroscopies, mass spectrometry as well as by comparison with literature data. Multiple purification of the leaves crude extracts yielded a new flavonoid, identified as 5-hydroxy-2",2"-dimethylpyrano- [5",6",11",12":6,7,3',4'] flavone together with known compounds i.e. carpachromene, cycloartocarpesin, 2′-hydroxy-4,4′,6′-trimethoxychalcone, norartocarpetin, friedelin, lupeol, and β-sitosterol. Five known compounds, characterized as artobiloxanthone, artonin E, catechin, lupeol 3-acetate, and friedelin were isolated from the barks crude extracts. Evaluations on biological activities were performed by using antibacterial, antioxidant, and cytotoxic assays on the pure compounds. Artobiloxanthone and artonin E were found to have antibacterial activity against Pseudomonas aeruginosa and Bacillus subtilis with MIC values in the range of 62.5-250 μg/mL, while MBC values were at 125-500 μg/mL. Catechin and artonin E showed high ability to act as free radical scavenger with SC 50 values of 19.4 µg/mL and 38.2 µg/mL respectively. The cytotoxic
Show more

36 Read more

Chemical Constituents of Artocarpus odoratissimus from Sarawak

Chemical Constituents of Artocarpus odoratissimus from Sarawak

The genus Artocarpus belonging to the family of Moraceae consists of about 55 species. It is widely distributed throughout subtropical and tropical regions of the World from Indian subcontinent south of the Himalayas, Sri Lanka, Burma, Thailand, Indo-China, Southern China, Taiwan and Malay Peninsula (Kochummen, 2000). Artocarpus odoratissimus originated in Borneo. It is cultivated in the Philippines and is also found in the wild extensively in Brunei Darussalam, Sabah and Sarawak (Subhadrabandhu, 2001). Some Artocarpus species are used as traditional medicines. For example A. odoratissimus (terap) isused by local communities in Sarawak as an antidote
Show more

5 Read more

Characterisation of Artocarpus Heterophyllus Fibre Reinforced Composite

Characterisation of Artocarpus Heterophyllus Fibre Reinforced Composite

Fibre sheets are made from Artocarpus heterophyllus fibres with the following steps. Firstly, AH’s peels are boiled for one hour and left to cool. The peels are then mixed with equal amount of water and are blended using blender for 3 minutes. Pulps undergone screening and sieving consistently over the sieve. After that, the pulps are transferred to wetted canvas, where it will be compressed into sheets under weights. The sheets are dried under the sun. AH papers are cut to 250 mm × 250 mm.

6 Read more

Immunostimulant Activity of Cocculus Hirsutus on Immunosuppressed Rat

Immunostimulant Activity of Cocculus Hirsutus on Immunosuppressed Rat

The humoral immunity involves interaction of B-cell with the antigen and their subsequent proliferation and differentiation into antibody secreting plasma cells. Antibody functions as the effectors of the humoral response by binding to antigen and neutralizing it or facilitating its elimination by cross – linking to form clusters that are more readily ingested by phagocytic cell .Aqueous and ethanolic extracts of Cocculus hirsutus increase the agglutination titre to SRBC (antigen). In crude aqueous extract agglutination titre increases, as increase in the dose .Ethanol soluble fraction did not show any significant increase in the agglutination titre as compared to control group. On the other hand, Ethanol insoluble fraction showed maximum increase in the agglutination titre at the dose of 100mg and 150 mg/kg b.wt. With these doses the agglutination was observed up to serum dilution of X: 320. Ethanolic extract and Water soluble fraction showed significant increase the agglutination titre in the dose of 150 mg/kg b.wt. .The titre observed up to serum dilution of X: 160.This indicates the enhanced responsiveness of macrophages and T and B lymphocyte subsets involved in antibody synthesis. [21]. Increased level of antibodies gives higher agglutination titre against sheep red blood cells [22].
Show more

20 Read more

Show all 138 documents...