aryl hydrocarbon receptor
The Aryl Hydrocarbon Receptor Governs Epithelial Cell Invasion during Oropharyngeal Candidiasis
... factor receptor (EGFR) on epithelial cells and stimulate endocyto- sis of the ...the aryl hydrocarbon receptor (AhR), leading to activa- tion of Src family kinases (SFKs), which in turn ...
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Aryl hydrocarbon receptor antagonism and its role in rheumatoid arthritis
... 66. Adachi M, Okamoto S, Chujyo S, et al. Cigarette smoke conden- sate extracts induce IL-1-beta production from rheumatoid arthritis patient-derived synoviocytes, but not osteoarthritis patient-derived synoviocytes, ...
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The Aryl Hydrocarbon Receptor: A Target for Breast Cancer Therapy
... The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates a battery of genes in re- sponse to exposure to a broad class of environmental poly aromatic hydrocarbons ...
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Roles for the Aryl Hydrocarbon Receptor in the Immune Response to Toxoplasma Gondii
... The cytokine IL-10 has an important role in limiting inflammation in many settings, including toxoplasmosis. In these studies, an IL-10 reporter mouse was used to identify the sources of this cytokine following challenge ...
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Original Article Expression of aryl hydrocarbon receptor in relation to p53 status and clinicopathological parameters in breast cancer
... The aryl hydrocarbon receptor (AhR) is a ligand activated transcription factor implicated in multiple cel- lular processes and its expression has been shown to play a critical role in ...
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Expression of the mediators of dioxin toxicity, aryl hydrocarbon receptor (AHR) and the AHR nuclear translocator (ARNT), is developmentally regulated in mouse teeth
... ABSTRACT Dioxins are persistent and ubiquitous environmental poisons that become enriched in the food chain. Besides being acutely lethal, the most toxic dioxin congener, 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD), is ...
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Gene Polymorphisms, Activation of the Aryl Hydrocarbon Receptor, and DNA Damage: A Preliminary Investigation
... Keywords: aryl hydrocarbon receptor; DNA damage; single nucleotide polymorphisms; 31.. BCL6; lymphoma.[r] ...
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Co-expression of the aryl hydrocarbon receptor and estrogen receptor in the developing teeth of rat offspring after rat mothers’ exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and the protective action of α-tocopherol and acetylsalicylic acid
... ameloblasts. Aryl hydrocarbon receptor was expressed at different levels in the pulp, alveolar bone and connective tissue surround- ing the teeth ...
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Follicle-stimulating hormone responsiveness in antral follicles from aryl hydrocarbon receptor knockout mice
... AHR: Aryl hydrocarbon receptor; AHRKO: Aryl hydrocarbon receptor knockout; α -MEM: Alpha-minimal essential media; ANOVA: Analysis of variance; CYP11A1: Cytochrome P450, family ...
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Evaluation of Estrogenic Receptor (ER) and Aryl Hydrocarbon Receptor (AhR) Agonists in Three Gorges Reservoir, China Using SPMD Based Virtual Organisms
... The Three Gorges Dam (TGD) constructed on the Yangtze River in China is the largest hydro-electricity project in the world and created the Three Gorges Reservoir (TGR) with an area of 1080 km 2 . The closing of the TGD ...
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Deletion of the Aryl Hydrocarbon Receptor Enhances the Inflammatory Response to Leishmania major Infection
... The aryl hydrocarbon receptor (AhR) is a ligand-activated receptor that mediates the toxicity of environmental pollutants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin ...
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Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor Mediated Pathway To Promote HIV 1 Infection and Reactivation
... to aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor which is involved in the regulation of a metabolism pathway that senses environmental toxins and endogenous ligands ...
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Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma
... Polyamine inhibition for cancer therapy is, conceptually, an attractive approach but has yet to meet success in the clinical setting. The aryl hydrocarbon receptor (AHR) is the central ...
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Role of the aryl hydrocarbon receptor in sugen 5416-induced experimental pulmonary hypertension
... 174 Results 175 AhR and CYP1A1 expression in Su/Hx male and female rat lungs 176 As discussed in the Introduction, we have previously shown that AhR expression is 177 increased in human [r] ...
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Neuronal functions of ahr 1, the Caenorhabditis elegans homolog of the aryl hydrocarbon receptor
... The key findings of this study are: 1 expression of ahr-1 in only 4 neurons, including URXR and URXL, is sufficient to restore aggregation behavior to ahr-1 mutant animals; 2 social feed[r] ...
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IMMUNOREGULATION OF LIVER REGENERATION BY THE ARYL HYDROCARBON RECEPTOR: ROLE OF LYMPHOCYTES AND INTERFERON-GAMMA
... Fc receptor block (BD Biosciences, San Jose, CA) for 10 minutes before staining with the following fluorochrome-conjugated antibodies purchased from BD Biosciences: ...
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Urolithin A Is a Dietary Microbiota-Derived Human Aryl Hydrocarbon Receptor Antagonist
... determine the antagonist capacity of urolithins, reporter human and mouse cells were co-treated 122.. with TCDD and urolithins as indicated for 4 h, followed by cell lysis and luciferas[r] ...
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Thermodynamics in cancers: opposing interactions between PPAR gamma and the canonical WNT/beta-catenin pathway
... muscle aryl‑hydrocarbon receptor nuclear translocator‑like1; CLOCK: circadian locomotor output cycles kaput; COX‑2: cyclooxygenase‑2; DSH: dishevelled; EMT: epithelial‑mesenchymal transition; FZD: ...
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Estrogen receptor beta inhibits transcriptional activity of hypoxia inducible factor 1 through the downregulation of arylhydrocarbon receptor nuclear translocator
... as aryl hydrocarbon receptor nuclear transloca- tor (ARNT) ...for aryl hydrocarbon receptor (AhR) function in 2,3,7,8-tetrachlorodibenzo-p- dioxin signalling ...
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Dendritic cells provide a potential link between smoking and inflammation in rheumatoid arthritis
... Of further relevance is the potential for smoking to influence T helper (Th)17 lymphocyte-mediated inflam- mation. Polycyclic aromatic hydrocarbons (PAHs) are amongst a number of compounds present in cigarette smoke that ...
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