Aspirin Induced Ulcer

Top PDF Aspirin Induced Ulcer:

Evaluation of antiulcer activity of crossandra infundibuliformis flower extract using aspirin induced ulcer model in albino rats

Evaluation of antiulcer activity of crossandra infundibuliformis flower extract using aspirin induced ulcer model in albino rats

Peptic ulcer is one of the major gastrointestinal disorders which is associated with increased morbidity and mortality (Suman sura et al., 2011). It mainly occurs due to the imbalance between gastric aggressive factors (Acid, Pepsin) and defensive factors (Mucus, Bicarbonate, Prostaglandin synthesis).Along with these various other factors like Helicobacter pylori infection, frequent use of NSAIDS, alcohol and nicotine consumption, stress also

5 Read more

“Gastroprotective Effect of Glycyrrhiz aglabra LINN. on Aspirin Induced Ulcer in Albino Rats” by Bhama Dhanabalan, Sampathkumar Palanisamy, B. Dheeba, Sheikabdulla Shahul Hameed, India.

“Gastroprotective Effect of Glycyrrhiz aglabra LINN. on Aspirin Induced Ulcer in Albino Rats” by Bhama Dhanabalan, Sampathkumar Palanisamy, B. Dheeba, Sheikabdulla Shahul Hameed, India.

Induction of gastric ulcer by aspirin caused a marked in increase in carbohydrates level (table 3). This indicates that Glycyrrhiza glabra Linn. helps in pretreating gastric injury and enhance and regenerating of gastric mucosa. The present study was under taken to find out the efficacy of ethanolic extract of Cocculus hirsutus against gastric ulcer that developed due to pyloric ligation in rats. Five groups (n=5) of Adult Albino rats were taken. Group-I was the control group. Group-II was given standard drug omeprazole (20mg/kg). Group III and IV were given 100mg/kg (low dose) and 200mg/kg (high dose) of ethanolic extract of Cocculus hirsutus respectively. The result indicated a significant reduction in the ulcer index, volume of gastric juice, free acidity and total acidity and increase in pH and protection after treatment with extract. The in vivo antioxidant studies were shown that the lipid peroxidation levels of the drug were decreased where as the levels of the nitrite, catalase and reduced glutathione seen to be increased. The result suggests that antioxidant and gastro protective activity of Cocculus hirsutus. 19 Animals pretreated with extract of Glycyrrhiza glabra Linn. given showed increased activity of ALP (table 3).
Show more

6 Read more

Critical appraisal of a fixed combination of esomeprazole and low dose aspirin in risk reduction

Critical appraisal of a fixed combination of esomeprazole and low dose aspirin in risk reduction

trial that compared aspirin plus esomeprazole with clopi- dogrel for patients who had previous aspirin-induced ulcer bleeding and were expected to continue low dose aspirin. Before randomization, healing of ulcers and eradication of H. pylori, if present, was documented. One hundred and fifty patients were assigned to receive aspirin plus esomeprazole and 161 patients were assigned to receive clopidogrel. The primary end point was recurrent ulcer bleeding as defined according to prespecified criteria – namely, hematemesis or melena with ulcers or bleeding erosions confirmed on endoscopy, or a decrease in the hemoglobin level of at least 2 g per deciliter in the presence of endoscopically documented ulcers or bleeding erosions.
Show more

6 Read more

ANTI ULCER ACTIVITY OF MORINGA OLEIFERA LEAVE’S EXTRACT IN SWISS ALBINO MICE AGAINST ASPIRIN INDUCED PEPTIC ULCER

ANTI ULCER ACTIVITY OF MORINGA OLEIFERA LEAVE’S EXTRACT IN SWISS ALBINO MICE AGAINST ASPIRIN INDUCED PEPTIC ULCER

Peptic ulcer is a disease characterized by mucosal damage that usually occurs in the stomach and proximal duodenum. [1] It is a serious injury occurring by spicy food, stress, alcohol, gastric surgery and Helicobacter pylori. [2] Aspirin (ASP), one of the most widely used NSAIDs, damages gastrointestinal mucosa by irritant action, causing alterations in mucosal permeability and/or suppression of prostaglandin synthesis. [3,4] Aspirin induced ulcer has been used as a model for the evaluation of anti-ulcerogenic agents. [5]
Show more

16 Read more

Anti-ulcer activity on siddha herbo-mineral formulation against aspirin induced gastric ulcer in rats

Anti-ulcer activity on siddha herbo-mineral formulation against aspirin induced gastric ulcer in rats

The gastro protective effects of Arputha mathirai were investigated against aspirin-induced ulcer model in rats. It has shown significant gastro protective effects against these models. Arputha mathirai has shown significant reduction in ulcer index as compared to control group in aspirin induced gastric ulcer model in both doses. Arputha mathirai 200mg/kg and 400mg/kg.b.wt were also significantly decreased ulcer index as compared to control group. Further the acid secretory parameters like total acidity, volume of gastric acid secretion and total acid output were also studied in aspirin-induced gastric ulcer model. Significant reduction was observed in total acid output and volume of gastric acid secretion although total acidity was observed to be reduced insignificantly against aspirin-induced gastric ulcer model as compared to control group.
Show more

5 Read more

Evaluation of Antiulcer Activity of Whole Plant Extract of Malvastrum tricuspidatum in Experimental Animals

Evaluation of Antiulcer Activity of Whole Plant Extract of Malvastrum tricuspidatum in Experimental Animals

Comparison of mean ulcer index among ethanol-induced ulcer, aspirin-induced ulcer, cold restraint ulcer and pylorus ligation models. Table 4[r]

7 Read more

Anti-ulcer Activity and HPTLC Analysis of Mangifera indica L. Leaves

Anti-ulcer Activity and HPTLC Analysis of Mangifera indica L. Leaves

roots 13 . This pharmacologically- active compound has been reported to have strong antioxidant 14 , anti lipid peroxidation, radioprotective 15 , immunomodulation 16 , anti-allergic 17 , anti-inflammatory and anti-nociceptive 18 , antitumour 19 , antidiabetic 20 , antidegenerative, wound healing, hypotensive, cardiotonic, lipolytic 21 , antibone resorption 22 , antiviral 23 , antibacterial 24 , antifungal 25 , antiparasitic 26 , monoamine oxidase-inhibiting activity 27 , hepatoprotective 28 and gastroprotective 29 activities. Various parts of the plant are used as a dentifrice, antiseptic, astringent, diaphoretic, stomachic, vermifuge, tonic, laxative and diuretic and to treat diarrhea, dysentery, anaemia, asthma, bronchitis, cough, hypertension, insomnia, rheumatism, toothache, leucorrhea, haemorrhage and piles. All parts are used to treat abscesses, broken horn, rabid dog or jackal bite, tumour, snakebite, stings, datura poisoning, heat stroke, miscarriage, anthrax, blisters, wounds in the mouth, tympanitis, colic, diarrhea, glossitis, indigestion, bacillosis, bloody dysentery, liver disorders, excessive urination and tetanus. Traditionally the plant is reported to have antiulcer activity 30 . In the present study, an effort has been made to establish the scientific validity to the antiulcer property of the leaves extracts of M. indica in aspirin induced ulcer in male albino rats.
Show more

10 Read more

A COMPARATIVE STUDY OF MICHELIA CHAMPACA LINN  FLOWER AND LEAVES FOR ANTI – ULCER ACTIVITY

A COMPARATIVE STUDY OF MICHELIA CHAMPACA LINN FLOWER AND LEAVES FOR ANTI – ULCER ACTIVITY

An ulcer is an imbalance between gastro damaging factors within the lumen and protective mechanisms in the gastro duodenal mucosa. Although prolonged anxiety, emotional stress, heamorrhagic surgical shock, burns and trauma are known to cause severe gastric irritation, the mechanism is still poorly understood 3 . However, implicated that oxygen derived free radicals has a role in the pathogenesis of a wide variety of clinical disorders and gastric damage caused by physical, chemical and psychological factors that leads to gastric ulceration in human and experimental animals 4 .
Show more

5 Read more

THE ANTI ULCEROGENIC ACTIVITY OF THE CRUDE METHANOLIC EXTRACT OF BERGIA SUFFRUTICOSA

THE ANTI ULCEROGENIC ACTIVITY OF THE CRUDE METHANOLIC EXTRACT OF BERGIA SUFFRUTICOSA

This study was carried out to evaluate the anti-ulcerogenic activity of the methanolic extract of Bergia suffruticosa to validate its traditional uses in treatment of stomach disturbances. The methanolic extract of Bergia suffruticosa was screened for its anti-ulcerogenic activity against induced-ulcer in four different models. The phytochemical studies of the plant showed that flavonoids,sterols, triterpenes, tannins, saponins and cuomarins are the main conistituents of the plant. The results showed that the methanolic extract of Bergia suffruticosa at a dose of 300 mg/kg was markedly decreased the incidence of ulcer that induced by aspirin in rat stomach and reduced ulcer index from 19.1±1.6 that induced by 150mg/kg aspirin to 10.8±07. Also inhibited H + ion concentration that had been stimulated by administration of histamine (2µg/kg) in rat stomach when the plant was given simultaneously at a dose 400ug/kg,with histamine and elevate the pH to 4.34±1.03 compared with the pH 3.14±1.20 that induced by administration of 2ug/ml histamine alone. Also B.s extract was antagonized histamine effect in contracting rat uterus and blocked the stimulant effect of histamine on guinea pig atrium.Also the extract antagonized ulcer induced by HCl/ethanol in mice by40.09%ulcer inhibition, compared with 50.54% that of sucralfate. The extract reduced water immersion stress induced ulcer in rat by 47.59%ulcer inhibition whereas that of omeprazole was 100%.The results obtained from this
Show more

11 Read more

Antiulcerogenic effect of gallic acid in rats and its effect on oxidant and antioxidant parameters in stomach tissue

Antiulcerogenic effect of gallic acid in rats and its effect on oxidant and antioxidant parameters in stomach tissue

total acidity, free acidity and pepsin concentration. Both the dose produced a significant effect, but the higher dose found more effective and produced almost similar effect to that of standard drug. Total and free acidity also decreases significantly (P<0.05) compare to ulcer control group. Pepsin concentration also significantly decreased after treatment with gallic acid. Gastric pH was significantly improved in the ulcer control group after treatment with gallic acid and famotidine (Table 1). These effects may contribute to the cytoprotective effect of gallic acid.
Show more

7 Read more

Evaluation of Antiulcerogenic Activity of Clerodendron Infortunatum Extract on Albino Rat Gastric Ulceration

Evaluation of Antiulcerogenic Activity of Clerodendron Infortunatum Extract on Albino Rat Gastric Ulceration

The ethanolic extract of C. infortunatum (EECI) showed significant gastric ulcer protective effect in doses of 100- 400 mg/kg, when given twice daily for 5 days against gastric ulcers induced by ethanol (EtOH), cold restraint stress (CRS) and pyloric ligation (PL). EECI showed dose dependent decrease in ulcer index (UI) against ulcers induced by: (i) Ethanol (control UI: 29.52±2.4 mm2/rat, EECI% decrease 28.45 -82.04%, PB/0.05 to PB/0.001); (ii) Cold restraint stress (control UI: 32.13±2.1, EECI% decrease 25.30 – 85.06%, PB/0.2 to PB/0.001); and (iii) Pylorus ligation (control UI: 29.25±2.4, EECI% decrease 22.32 - 80.85%, PB/0.1 to PB/0.001) (Table 1). A total of 50% acetic acid when applied to the serosal surface of rat gastric mucosa in the fundal region near to the pyloric end produced chronic gastric ulcers. EECI 400 mg/kg significantly healed ulcers induced by 50% acetic acid after 5 (control UI: 32.30±2.9, healing 18.67-73.49%, PB/0.001) and (control UI: 29.02±2.6, healing 26.67-80.08%, PB/0.01) after 10 days of treatment (Table 2).
Show more

6 Read more

THE EFFECT OF MUSA SAPIENTUM METHANOLIC FRUIT EXTRACT ON VOLUME OF GASTRIC JUICE AND PEPSIN ACTIVITY IN ASPIRIN INDUCED PEPTIC ULCERS IN ALBINO RATS

THE EFFECT OF MUSA SAPIENTUM METHANOLIC FRUIT EXTRACT ON VOLUME OF GASTRIC JUICE AND PEPSIN ACTIVITY IN ASPIRIN INDUCED PEPTIC ULCERS IN ALBINO RATS

ABSTRACT: The aim of the study was to evaluate the effect of Musa sapientum methanolic fruit extract on volume of gastric juice and pepsin activity in aspirin induced peptic ulcer in albino rats. The extract was prepared by percolation method. Volume of gastric juice was estimated by the method of Deshpande SS et al (2003). Pepsin activity was studied with the methods of Debnath PK et al (1974) and Lowry OH et al (1951). Twenty four healthy albino rats of 100-200 gms were divided into 4 groups of six animals each. Group I or control (3% gum acacia, 5 ml/kg orally for 7 days). Group II or experimental control (aspirin 400 mg/kg orally single dose on the 7th day). Group III or MSE group (MSE 100 mg/kg orally for 7 days and aspirin 400 mg/kg orally single dose on the 7th day). Group IV or standard (ranitidine 150 mg/kg orally for 7 days and aspirin 400 mg/kg orally single dose on the 7th day). On 8 th day the stomachs of the sacrificed rats were removed. The volume of gastric juice and pepsin activity were studied. The volume of gastric juice and pepsin activity in group III and IV showed significant decrease in comparison to group II (p <0.01). Both Musa sapientum fruit extract and the ranitidine significantly (p <0.01) reduced volume of gastric juice and pepsin activity.
Show more

5 Read more

Anti-Ulcer and Analgesic Activity of Ethanolic Extract of Annona Squamosa Leaves.

Anti-Ulcer and Analgesic Activity of Ethanolic Extract of Annona Squamosa Leaves.

It is suggested that these compounds will be able to stimulate mucus, bicarbonate and prostaglandin secretion, and counteract with the deteriorating effects of reactive oxidants in gastrointestinal lumen. (suja pandian et.al., 2002) Tannins are known to “tan” the outermost layer of the mucosa and render it less permeable and more resistant to chemical and mechanical injuries. Tannins may prevent ulcer development due to their protein precipitating and vasoconstriction effects. Their astringent action can help precipitating micro proteins on the ulcer site, thereby forming an impervious layer over the lining that hinders gut secretions and protects the underlying mucosa from toxins and other irritants.(Berenguer B et al .,2005)
Show more

96 Read more

Evaluation of Pep-Up Tablet for In-Vitro Digestive Property and In-Vivo Anti-ulcer Activity

Evaluation of Pep-Up Tablet for In-Vitro Digestive Property and In-Vivo Anti-ulcer Activity

Gastrointestinal (GI) problems are the most common and widespread health complaints among the general populace. Amongst them Indigestion (Dyspepsia) is a very common primary care concern. 1 The term Indigestion (Dyspepsia) refers to a cluster of symptoms thought to arise in the upper gastrointestinal tract. It comprises symptoms such as epigastric pain, regurgitation, heartburn, belching, nausea, vomiting, and early satiety. 2 Indigestion may be triggered by eating spicy, fatty or greasy foods, eating too fast, overeating, drinking too much alcohol, emotional stress etc. Other causes of indigestion are gallstones, gastritis, stomach or intestinal ulcers, use of drugs such as antibiotics, aspirin, and non-steroidal anti-inflammatory drugs (NSAIDs). 3 According to Ayurveda, the word Ajirna means bad digestion. It is defined as a pathological condition in which food is not digested easily and is the root cause for many internal diseases (metabolic). In conventional medicine, the term Dyspepsiasis, derived from the Greek words dys (bad) and pepsis (digestion), refers to symptoms thought to originate in the upper GI tract. 4 Surveys in Western societies have recorded a prevalence of this condition between 23 and 41%. The specific record of prevalence in the U.S. is 26% and 41% in the U.K. Although only 20 to 25% of persons with dyspepsia seek medical care only 2 to 5% of problems reaches to primary care physicians. 5 In India, 49.40% population is suffering from digestive problems amongst them 21.10% is aging between 12-20 years and 76.20% is aging above 70 years. 6
Show more

5 Read more

Pharmacological Evaluation of Methanolic Extract of Leaves of Artocarpus Hirsutus Lam.

Pharmacological Evaluation of Methanolic Extract of Leaves of Artocarpus Hirsutus Lam.

Gastrointestinal disorders are one of the severe classes of human ailments causing maximum discomfort, morbidity and mortality. Peptic ulcer is one such gut disorder. Peptic ulcer is a benign lesion of gastric or duodenal mucosa occurring at a site where the mucosal epithelium is exposed to acid and pepsin. There are several causes including, stress, alcohol consumption, cigarette smoking, H. pylori infection, ingestion of drugs and chemicals. Especially consumption of alcohol for a prolonged period, smoking of cigarettes, or chronic consumption of NSAIDs are causing peptic ulcers. The role of free radicals in the pathogenesis of peptic ulcer due to mucosal damage is established. The symptoms of peptic ulcer are severe pain and irritation in the upper abdomen. If it is not treated properly, it may results in perforations in the wall of the gastrointestinal tract.
Show more

127 Read more

Evaluation of antiulcer and thrombolytic activity of aqueous extract of Tiliacora acuminata bark in albino wistar rats

Evaluation of antiulcer and thrombolytic activity of aqueous extract of Tiliacora acuminata bark in albino wistar rats

The etiology of peptic ulcer is unknown in most of the cases, yet it is generally accepted that it results from an imbalance between aggressive factors and the maintenance of mucosal integrity through the endogenous defence mechanisms. To regain the balance, different therapeutic agents including plant extracts may be used.Aqueous extract of Tiliacora acuminata.is one such herbal drug used in the present study primarily to evaluate the anti-ulcer genic in pylorus ligation and aspirin induced ulcers in rats. The causes of gastric ulcer pyloric ligation are believed to be due to stress induced increase in gastric hydrochloric acid secretion and/or stasis of acid and the volume of secretion is also an important factor in the formation of ulcer due to exposure of the unprotected lumen of the stomach to the accumulating acid. Pylorus ligation induced ulcers are due to auto digestion of the gastric mucosa and breakdown of the gastric mucosal barrier. These factors are associated with the development of upper gastrointestinal damage including lesions, ulcers and life threatening perforation and haemorrhage.
Show more

7 Read more

ANTIULCER EVALUATION OF MUSSAENDA GLABRATA LEAVES ON EXPERIMENTALLY INDUCED ULCER MODELS OF RAT

ANTIULCER EVALUATION OF MUSSAENDA GLABRATA LEAVES ON EXPERIMENTALLY INDUCED ULCER MODELS OF RAT

closed with interrupted sutures. Food and water were deprived after the post-operative period. The animals were kept for 6hrs under experimental conditions. The animals are sacrificed 6hrs after the pylorus ligation and the abdomen was opened, stomach were removed, cut along greater curvature, washed with normal saline and examined for ulcers. At the end of treatment, the mucosa of animals in each group was examined under microscope. Gastric tissue samples from each group of pylorus ligation model were fixed in 10% formalin for histological studies. Ulcer index, volume of gastric juice, pH, free acidity, and total acidity are used as parameters for assessing antiulcer activity.
Show more

15 Read more

  PROTECTIVE EFFECT OF CHENOPODIUM ALBUM ETHANOLIC EXTRACT AGAINST ASPIRIN INDUCED PEPTIC ULCER IN RAT MODEL 

  PROTECTIVE EFFECT OF CHENOPODIUM ALBUM ETHANOLIC EXTRACT AGAINST ASPIRIN INDUCED PEPTIC ULCER IN RAT MODEL 

Chenopodium album, is a commonly used plant in Indian traditional medicine belongs to family Chenopodiaceae. In our study, anti-ulcer activity of its ethanolic extracts of whole plant were investigated using Wistar rats as animal models. Extracts were also subjected to phytochemical analysis and found to contain Carbohydrates, Proteins, Flavonoids, Tannins and phenolic compounds. Chenopodium album alcoholic extracts were found to be non-toxic up to 1500 mg/kg dose level. During confirmation of the claimed anti-ulcer activity, treatment with two different alcoholic extracts in 200mg and 400 mg/kg showed significant reduction in ulcer index, free acidity as well as total acidity in pylorus ligated rats. However, profound reduction in all these indices was observed with both of the doses. But higher dose of extract showed relatively significant protection.
Show more

7 Read more

Effect of Aqueous Extract of Some Indian Medicinal Plants against Aspirin Induced Gastric Ulcer in Rats

Effect of Aqueous Extract of Some Indian Medicinal Plants against Aspirin Induced Gastric Ulcer in Rats

Before ulcer induction animals of both control and experimental groups kept separately in standard controlled conditions were fasted for 24 h with free access to water. Acute gastric ulcers were induced by oral administration of aspirin at a dose of 20 mg kg_1 body weight and rats were sacrificed after 4 h of aspirin treatment. The control group received the vehicle only, whereas the experimental group received aspirin for gastric ulceration. After 4 h, the animals were sacrificed, and gastric lesions in the fundic stomach were scored and expressed as ulcer index. L.camara, A.muricata, K.pinnataleaves aqueous extract was administered orally 30 min prior to aspirin treatment to see the gastroprotective effect. Rabeprazole were administered orally at a dose of 20 mg/ kg body weight respectively.
Show more

11 Read more

Aspirin for venous ulcers: randomised trial (AVURT): study protocol for a randomised controlled trial

Aspirin for venous ulcers: randomised trial (AVURT): study protocol for a randomised controlled trial

The AVURT is designed to inform the feasibility of a larger, confirmatory study of aspirin therapy for VLU. AVURT is a phase II randomised, double blind, parallel-group, placebo- controlled study to provide evidence regarding the efficacy and safety of aspirin (at a dose of 300 mg once daily), in addition to standard care in patients with chronic VLUs. A chronic VLU is defined as any break in the skin that has ei- ther: a) been present for more than 6 weeks, or b) occurred in a person with a history of venous leg ulceration. Ulcers will be considered venous if no other aetiology is clinically suspected. The ulcer must be venous in appearance (i.e. moist, shallow and irregular of appearance) and lie wholly or partially within the gaiter area of the leg. Potential partic- ipants will be identified from hospital outpatient clinics or community leg ulcer clinics, where they usually receive treatment for VLUs. An additional file shows the schematic of the AVURT trial design (see Additional file 2). All partic- ipants will continue to receive ‘standard care’ according to an evidence-based standardised approach to the manage- ment of VLUs, as per SIGN guidelines [13] with multi- component compression therapy aiming to deliver 40 mmHg of pressure at the ankle. The type of dressing used will be at the discretion of the healthcare professional man- aging the patient and will be documented in the participant case report form (CRF).
Show more

9 Read more

Show all 10000 documents...