ATP binding cassette protein gene (ABCA1)
A study of genetic polymorphism in ATP binding cassette protein gene (ABCA1) among type 2 diabetes mellitus (DM) patients
... ABCA1 gene polymorphisms have been associated with abnormalities of both serum levels of HDL-c and the quality of HDL-c. Understanding the pathological mechanisms underlying HDL-c dysfunction may allow the ...
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ATP-binding cassette transporter A1 gene polymorphisms and serum lipid levels in young Greek nurses
... The ATP-binding cassette transporter A1 (ABCA1) acts as a vehicle for cellular cholesterol which after crossing cell membrane bounds to acceptor molecule such as apolipoprotein (apo) A ...ABCA1 ...
6
ATP-binding cassette (ABC) transporters in normal and pathological lung
... ATP-binding cassette (ABC) transporters are a family of transmembrane proteins that can transport a wide variety of substrates across biological membranes in an energy-dependent ...
16
A Review on ATP Binding Cassette (ABC) Transporters
... key protein in controlling the cellular apolipoprotein-mediated lipid removal pathway 41-42 ...ABCA1 gene result in Tangier disease, a genetic disorder characterized by an abnormal lipoprotein profile and ...
9
Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors
... the ATP-binding cassette transporter A- 1 (ABCA1), ABCA7, apolipoprotein C2 (APOC2), APOC4, and phospholipid transfer protein (PLTP); the complement pathway VTN gene; and the ...
20
RPE phagocytic function declines in age related macular degeneration and is rescued by human umbilical tissue derived cells
... Other genes we identified of specific interest that are upregulated by hUTC CM treatment are SOD2 and ABCA1. The upregulation of SOD2 and ABCA1 by hUTC CM treatment indicates a protective role of hUTC-secreted factors ...
15
The impact of ATP-binding cassette transporters on metabolic diseases
... the gene expression of ...triphosphate-binding cassette; oxLDL: Oxidized low-density lipoproteins; LOX-1: Lectin-like oxidized low-density lipoprotein receptor-1; ROS: Reactive oxygen species; LPS: ...
14
Molecular chess? Hallmarks of anti cancer drug resistance
... The ATP-binding cassette (ABC) superfamily of proteins includes a number of membrane proteins able to transport a wide diversity of ...) gene, which en- codes a membrane-based xenobiotic pump ...
8
Insight into the role of p62 in the cisplatin resistant mechanisms of ovarian cancer
... the gene transcription of several important enzymes involved in GSH synthesis and oxidation, maintaining the mitochon- drial GSH pool ...encoding ATP-binding cassette (ABC) transporters (known ...
11
WNT signaling – lung cancer is no exception
... ABC: ATP-binding cassette; ABCB1: ATP-binding cassette transporter protein B1; ABCG2: ATP-binding cassette transporter protein G2; AC: ...
16
Towards the clinical implementation of pharmacogenetics in bipolar disorder
... ABCB1: gene for an ATP binding cassette transporter protein; AIM: antidepressant-induced mania; ANKK1: ankyrin repeat and kinase domain containing 1; BD: bipolar disorder; BDNF: ...
15
Copy number variations of the ATP binding cassette transporter ABCC6 gene and its pseudogenes
... The ATP-binding cassette transporter ABCC6 belongs to a large family of membrane proteins (ABC transpor- ters) that are a highly conserved and present in all organisms from bacteria to man ...ABCC6 ...
6
Human ATP-binding cassette (ABC) transporter family
... ABC gene first appeared in unicellular organisms and is therefore ancient, being now present in eubacteria, archaebacteria, plants, fungi, yeast and all ...ABC gene family is the same as that developed for ...
10
An ATP-binding cassette-type cysteine transporter in Campylobacter jejuni inferred from the structure of an extracytoplasmic solute receptor protein
... couple ATP hydrolysis to solute trans- location (Holland et ...cj0982c gene is not genetically linked to genes encoding other ABC trans- porter ...the gene for an ...ESR gene away from the ...
14
Original Article Two SNPs of ATP-binding cassette B1 gene on the risk and prognosis of colorectal cancer
... two gene polymorphism can play an important role in susceptibility of developing cancer, but their biological significance is not fully understood ...brane protein, and it acts as an energy-dependent drug ...
7
ABC transporter research: going strong 40 years on
... The ATP-binding cassette (ABC) transporter field emerged from studies on nutrient uptake in bacteria in the 1970’s with the biochemical characterization of substrate-binding protein ...
9
Roles of sphingosine-1-phosphate signaling in cancer
... S1P, whether produced by SphK1 or SphK2, owes almost all of its bioactive pleiotropic effects on cell sur- vival, migration, angiogenesis, and lymphangiogenesis and immune cell recruitment, all processes that may be ...
12
Fluconazole resistance in <em>Candida</em> species: a current perspective
... As with many topics in C. auris, much is unknown concern- ing the contribution of ERG11 point mutations to fluconazole resistance. However, one recent study determined that a col- lection of C. auris isolates with ...
9
Studies on the human choroid plexus in vitro
... Human CP samples may be obtained as spare material from neurosurgery. In most cases, a small amount of healthy CP tissue has to be dissected during surgical removal of a large choroid plexus papilloma. An import- ant ...
7
Acetylsalicylic acid, aging and coronary artery disease are associated with ABCA1 DNA methylation in men
... of gene expression levels of ABCA1 and other key genes involved in reverse cholesterol transport in humans ...ABCA1 gene DNA methylation levels, leading in turn to the stimulation of the reverse cholesterol ...
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