ATP-dependent potassium channels
The pharmacology of calcium and ATP-dependent potassium channels in erythrocytes and in smooth skeletal muscle
... Potassium channels are a diverse class of membrane proteins found in virtually all cells. The first part of this study concerns the pharmacology of the calcium activated potassium channel found in ...
215
ATP-dependent potassium channels are implicated in simvastatin pretreatment-induced inhibition of apoptotic cell death after renal ischemia/reperfusion injury
... Another potential mechanism of in- creased apoptotic cell death after I/R in- jury is upregulation of Bax which has been demonstrated by Jin et al. to be mediated by p53 transcription factor ac- tivation. According to ...
10
The Mechanism of Preventive Effect of Captopril on Renal Ischemia Reperfusion Injury is Independent of ATP Dependent Potassium Channels
... regulation of vasoactivity in vascular beds, including the renal medulla, has been examined by testing the ability of glibenclamide to lower blood flow. Gardiner and colleagues [15] found that glibenclamide infusion into ...
5
In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root
... Although oroxylin A will most likely never be used clini- cally to achieve tocolysis, the data presented here clearly demonstrate that oroxylin A is able to relax pregnant rat myometrium through a mechanism involving ...
7
Increase of ATP-sensitive potassium (KATP) channels in the heart of type-1 diabetic rats
... Effects of hyperglycemia on SUR-2A and Kir6.2 expres- sion levels were further characterized by exposing cul- tured neonatal rat cardiac myocytes to various concentrations of glucose in vitro. The SUR-2A and Kir6.2 ...
9
The involvement of ATP-sensitive potassium channels in novel forms of myocardial protection
... increased ATP^, for which ATP hydrolysis is not required but on the other hand ATP hydrolysis is necessary to maintain the channel in an operative state ...of ATP^, PKC upregulates the K^^p ...
164
Regulation of vascular ATP-sensitive potassium channels by calcium and inflammatory mediators
... Ca^"^- dependent and -Independent Isoforms exist, although how specificity of action Is achieved Is not completely ...Ca^* channels, K^ channels and phosphollpases (Andrea and Walsh, ...
281
Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia
... Up-regulation of Kir6.1 gene expression in endotoxe- mic mice is consistent with data from mouse smooth muscle cells showing a transcription dependent up- regulation after 20 h of LPS exposure [11]. Like Weiwei, a ...
10
Glibenclamide inhibits cell growth by inducing G0/G1 arrest in the human breast cancer cell line MDA-MB-231
... the potassium-dependent changes in membrane potential play a crucial role in the proliferation of many types of normal and tumor ...of potassium channels in the cell mem- brane produces a ...
13
Functional cell biology and molecular pharmacology of ATP sensitive potassium channels
... octomeric combinations of two distinct types of protein subunit. The pore is formed of four Kir6.1 or Kir6.2 subunits, each of which is associated with a regulatory sulphonylurea receptor (SUR) subunit. Kir6.1 and Kir6.2 ...
125
Lactate activates ATP sensitive potassium channels in guinea pig ventricular myocytes
... of ATP at which activation of the channels occurs and the much higher levels of ATP maintained during myocardial ...on ATP-sensitive potassium channels in adult guinea pig ...
7
Modulation of pulmonary vasomotor tone in the fetus and neonate
... ), ATP- dependent (K ATP ), and several voltage-dependent (K V ) potassium channels have been identified on both pulmonary endothelial and vascular smooth muscle ...endothelial ...
6
Role of sarcolemmal KATP channels in cardioprotection against ischemia/reperfusion injury in mice
... mitochondrial ATP-sensitive K + (mitoK ATP ) channels rather than sarcolemmal K ATP (sarcK ATP ) channels are important as end effectors and/or triggers of ischemic ...
9
ATP-sensitive Potassium Channels and L-type Calcium Channels are Involved in Morphine-induced Hyperalgesia after Nociceptive Sensitization in Mice
... algesia in a diabetic mice model (Ahmadi, Ebrahimi, Oryan & Rafieenia, 2013), and it was observed that the blocker of these channels decreased the diabetes- induced hyperalgesia . On the contrary, the present ...
8
CFTR is required for PKA regulated ATP sensitivity of Kir1 1 potassium channels in mouse kidney
... Effects of Mg-ATP on ROMK channel in inside-out patches from TAL apical membrane. (A) Cytosolic Mg-ATP (1 mM) strongly reduced wild-type ROMK channel activity, which was partially recov- ered after removing ...
12
Estimation of ATP-dependent K(+)-channel contribution to potential-dependent potassium uptake in the rat brain mitochondria
... of potassium on state 4 respiration (substrate oxidation in the absence of ADP) was in - ...potential-dependent potassium uptake in the brain mitochondria results in mitochondrial ...of ...
8
Role of Kir6.2 subunits of ATP-sensitive potassium channels in endotoxemia-induced cardiac dysfunction
... channels may offer protection against apoptosis in endotoxemia [10]. Thus, the first aim of this work was designed to assess the role of Kir6.2 subunits on cardiac function and cardiac damage under LPS ...
8
Nicorandil-Induced Hyperkalemia in a Uremic Patient
... and ATP-sensitive potassium channel activator ...of potassium channels, potassium ions are expelled out of the cells, which lead to membrane hyperpolarization, closure of voltage-gated ...
5
ATP sensitive potassium channels mediate contraction induced attenuation of sympathetic vasoconstriction in rat skeletal muscle
... In our experiments, glibenclamide also attenuated active hyperemia, which is consistent with previous studies in the ca- nine diaphragm (35, 36) and hamster cremaster muscle (37). We therefore considered the possibility ...
9
Glucose modulates rat substantia nigra GABA release in vivo via ATP sensitive potassium channels
... on ATP-sensitive potassium (KATP) ...of ATP by perfusion of 2-deoxyglucose with oligomycin inhibited GABA release by 44 +/- 8 and 45 +/- 11%, ...KATP channels and that inhibition of GABA ...
7