ATP-sensitive K+ channel
Activation of the mitochondrial ATP-sensitive K+ channel reduces apoptosis of spleen mononuclear cells induced by hyperlipidemia
... We have previously used these hypertriglyceridemic mice (HTG mice) to investigate the effects of hyperlipid- emia on liver mitochondrial bioenergetics and redox state. We have found that liver mitochondria from HTG mice ...
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Kir6.2-containing ATP-sensitive K+ channel is required for cardioprotection of resveratrol in mice
... reperfusion (Figure 4A), suggesting that AMPK may be in- volved in cardioprotective effects of resveratrol. To further identify the roles of AMPK in cardioprotection of resvera- trol, cardiomyocytes were treated with ...
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The ATP sensitive K+ channel mediates hypotension in endotoxemia and hypoxic lactic acidosis in dog
... the K+ATP channel, caused vasoconstriction and restoration of blood ...the K+ATP channel in vascular smooth muscle, and anaerobic metabolism with acidosis is a sufficient ...
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Butylidenephthalide antagonizes cromakalim induced systolic pressure reduction in conscious normotensive rats
... Bdph was reported to inhibit Ca 2+ influx and cause re- laxation in guinea-pig ileum [15], rat aortic ring [8] and rabbit aortic strip [6]. Bdph was also reported to increase flow in isolated guinea-pig heart [16] and ...
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Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels?
... regarding ATP-sensitive K ⫹ channels in smooth muscle, for which there is substantial literature supporting inhibitory regulation by ...muscle ATP-sensitive K ⫹ channel ...
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Expression and function of K(ATP) channels in normal and osteoarthritic human chondrocytes: possible role in glucose sensing
... ‐ sensitive potassium [K(ATP)] channels sense intracellular ATP/ADP levels, being essential components of a glucose ‐ sensing apparatus in various cells that couples glucose metabolism, ...
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Effect of ATP-Dependent K+ Channel Openers and Blockers on Serum Concentration of Aldosterone in Rats
... This study demonstrated that under in vivo conditions glibenclamide had an antagonistic effect against the hyperaldosteronemic action of diazoxide. Antagonistic effect of diazoxide on renin secretion was also susceptible ...
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CFTR is required for PKA regulated ATP sensitivity of Kir1 1 potassium channels in mouse kidney
... – channel plays vital roles in fluid transport in many ...pS, ATP-sensitive renal K channel ...medullar K [ROMK]) that is critical for K secretion by cells of the thick ...
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Activating Mutations in the Gene Encoding the ATP-Sensitive Potassium-Channel Subunit Kir6.2 and Permanent Neonatal Diabetes
... Whole-cell currents were recorded in a two-electrode volt- age clamp from intact oocytes expressing Kir6.2–SUR1 (Panel A) or Kir6.2-R201H–SUR1 (Panel B) in response to voltage steps of ±20 mV from a holding potential of ...
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The effect of ATP-dependent K(+)-channel opener on the functional state and the opening of cyclosporine-sensitive pore in rat liver mitochondria
... канала является система окислительного фосфорилирования митохондрий. несмотря на ее частичное ингибирование, подавление гидролиза АТР должно снижать непродук- тивный расход АТР, синтезируемого в этих органеллах и ...
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Intracellular ATP can regulate afferent arteriolar tone via ATP sensitive K+ channels in the rabbit
... segments. Channel activity was markedly reduced by 1 mM ATP and in a dose-dependent fashion by glibenclamide (10(-9) M to 10(-6) M), a specific antagonist of KATP ...a K+ channel opener, ...
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The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes
... (K ATP ) channel ...β-cell, K ATP channel activity couples glucose metabolism to insulin secretion via cellular excitability and mutations in either KCNJ11 or ABCC8 genes alter ...
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Regulation of the mitochondrial ATP-sensitive potassium channel in rat uterus cells by ROS
... mitoK ATP , depolarized mitochondrial membrane either under oxidative stress or under normal conditions, while mitoK ATP blocker glyben- clamide effectively restored mitochondrial poten- tial in rat ...
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Role of sarcolemmal KATP channels in cardioprotection against ischemia/reperfusion injury in mice
... mitochondrial ATP-sensitive K + (mitoK ATP ) channels rather than sarcolemmal K ATP (sarcK ATP ) channels are important as end effectors and/or triggers of ischemic ...
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The pharmacology of calcium and ATP-dependent potassium channels in erythrocytes and in smooth skeletal muscle
... multi-ion channel (Hille and Schwarz 1978). In this model the channel can be occupied by several ions at once but they are constrained to move in single ...the channel one might expect that the ...
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Blocking ATP-sensitive potassium channel alleviates morphine tolerance by inhibiting HSP70-TLR4-NLRP3-mediated neuroinflammation
... ABC: ATP-binding cassette; ASC: Apoptosis-associated speck-like protein; ATP: Adenosine triphosphate; BMDMs: Bone marrow-derived macrophages; CFTR: Cystic fibrosis transmembrane conductance regulator; CGRP: ...
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Estimation of ATP-dependent K(+)-channel contribution to potential-dependent potassium uptake in the rat brain mitochondria
... ем скорости дыхания, повышение концентрации калия в среде также приводит к снижению мем - бранного потенциала, ΔΨ m (рис. 2, А, черные точки 1). Митохондриальная деполяризация не устраняется внесением цитохрома с в среду ...
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Effects of exogenous free radicals on electromechanical function and metabolism in isolated rabbit and guinea pig ventricle Implications for ischemia and reperfusion injury
... cellular K+ efflux, shortening of the action potential duration, changes in tension, and depletion of high energy phosphates similar to ischemia and metabolic ...activated ATP-sensitive K+ ...
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Nicorandil-Induced Hyperkalemia in a Uremic Patient
... Copyright © 2012 Hung-Hao Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
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Modulation of ex-vivo uterine contraction by the methanol leaf extract of Alchornea laxiflora Benth. (Euphorbiaceae) and preliminary spectrometric identification of associated secondary metabolites
... Effect of extract on oxytocin-induced uterine contractions in the presence of amiodarone, a K+ATP-dependent channel blocker A further inhibition of OT-induced 0.05 mM uterine contraction[r] ...
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