ATP-sensitive potassium channel
The effect of ATP sensitive potassium channel modulation on heart rate in isolated muskrat and guinea pig hearts
... extracellular potassium concentration during metabolic stress are thought to be mediated primarily by the ATP-sensitive potassium ...Anion-coupled potassium efflux, ...the ...
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Blocking ATP-sensitive potassium channel alleviates morphine tolerance by inhibiting HSP70-TLR4-NLRP3-mediated neuroinflammation
... Fig. 2 Extracellular HSP70 triggers inflammatory response dependent on TLR4 in microglia. a, b Recombinant mouse HSP70 (100 ng/mL, 12 h) upregulated the phosphorylation of p38 MAPK and NF- κ B p65 in BV-2 cells. Cell ...
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Activating Mutations in the Gene Encoding the ATP-Sensitive Potassium-Channel Subunit Kir6.2 and Permanent Neonatal Diabetes
... Six novel, heterozygous missense mutations were identified in 10 of the 29 patients. In two patients the diabetes was familial, and in eight it arose from a spontaneous muta- tion. Their neonatal diabetes was ...
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The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes
... comparable ATP sensitivity to the channel contain- ing all wild-type subunits, so the resulting ATP sensitivity of heterozygous population is very close, but not identical, to that of a pure ...
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Regulation of the mitochondrial ATP-sensitive potassium channel in rat uterus cells by ROS
... mitoK ATP , depolarized mitochondrial membrane either under oxidative stress or under normal conditions, while mitoK ATP blocker glyben- clamide effectively restored mitochondrial poten- tial in rat ...
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An investigation of the biochemical interaction between subunits of the ATP-sensitive potassium channel
... or potassium selectivity were shown to produce channels with altered rectification properties or non-fimctional channels (Shyng ...heteromeric channel (Tucker et. al., 1997). Furthermore, it was found that ...
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Curcumin inhibits proliferation of gastric cancer cells by impairing ATP sensitive potassium channel opening
... Modern medical studies found that this bioactive agent, extracted from the rhizome of a herb named Curcuma Longa Linn, exerted potent anti-cancer activity by inhi- biting cell proliferation in vitro and in vivo [31]. The ...
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Nicorandil-Induced Hyperkalemia in a Uremic Patient
... and ATP-sensitive potassium channel activator ...of potassium channels, potassium ions are expelled out of the cells, which lead to membrane hyperpolarization, closure of ...
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Potential therapeutic targets for hypoxia induced pulmonary artery hypertension
... ATP sensitive potassium channel and the depolarization induced by hypoxia [14]. PAH is a severe disease and ac- counts for most deaths of chronic obstructive pulmonary diseases, and remodeling ...
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Conversion of amylase secreting rat pancreatic AR42J cells to neuronlike cells by activin A
... of ATP-sensitive potassium channel in activin-treated ...express ATP-sensitive potassium channel as well ...
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Glucose modulates rat substantia nigra GABA release in vivo via ATP sensitive potassium channels
... on ATP-sensitive potassium (KATP) ...KATP channel activator, lemakalim, or depletion of ATP by perfusion of 2-deoxyglucose with oligomycin inhibited GABA release by 44 +/- 8 and 45 +/- ...
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The involvement of ATP-sensitive potassium channels in novel forms of myocardial protection
... K^^-p channel blocker 5HD, n ow thought to be specific for mito-K^jp, channels, suggests a role for these particular channels in the adaptation of the myocardium to ...
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Regulation of vascular ATP-sensitive potassium channels by calcium and inflammatory mediators
... 1991; Thiemermann, 1997). In addition, Hall et al., (1996) found that the LPS- induced hyporeactivity to the a-adrenergic agonist, phenylephrine couid be fuliy reversed with tetraethylammonium (TEA), a non-selective ...
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ATP-sensitive Potassium Channels and L-type Calcium Channels are Involved in Morphine-induced Hyperalgesia after Nociceptive Sensitization in Mice
... K+ATP channel block- ers antagonize the analgesic effects of opioids (Ocana, Del Pozo, Barrios & Baeyens, 1995; Ocana, Del Pozo, Barrios, Robles & Baeyens, 1990; Wild, Vanderah, Mosberg & ...
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Functional cell biology and molecular pharmacology of ATP sensitive potassium channels
... intracellular potassium ion (K+) concentration that is twenty five times higher than the external K+ ...a potassium channel opens, an efflux of positive charge and an outward current ...for ...
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Expression of ATP-sensitive potassium channels in human pregnant myometrium
... abundant potassium channels and likely contri- butes to the resting membrane potential in smooth mus- cle tissues ...The channel comprises heteromultimers of an inwardly rectifying K + channel (Kir) ...
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Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia
... Involvement of the ATP-dependent potassium channel Kir6.1 in systemic circulation has been demonstrated in numerous studies. Kir6.1 expression is up-regulated in rats in LPS as well as in cecal ...
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Increase of ATP-sensitive potassium (KATP) channels in the heart of type-1 diabetic rats
... Due to the difference between human and animal and/ or the stage of diabetes, the response of blood pressure is varied; changes of blood pressure in diabetic compli- cations seem not so simple. Numerous evidences sug- ...
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Molecular cloning of a glibenclamide sensitive, voltage gated potassium channel expressed in rabbit kidney
... total volume of 30 m l. The reaction mixture was overlaid with 50 m l of mineral oil and incubated at 50 8 C for 16 h. The total amount of RNA in each sample was kept constant (100 m g) by adding the appropriate amount ...
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ATP sensitive potassium channels mediate contraction induced attenuation of sympathetic vasoconstriction in rat skeletal muscle
... channel blocker glibenclamide (20 mg/kg i.v.) are presented in Table II. In the absence of glibenclamide, hindlimb contrac- tion significantly increased femoral blood flow velocity and vascular conductance. ...
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