ATP-sensitive potassium current
Potential therapeutic targets for hypoxia induced pulmonary artery hypertension
... ATP sensitive potassium channel and the depolarization induced by hypoxia ...the current study, Changes in Δψm, as indi- cated by the intensity of R-123 ...mitoK ATP channels was ...
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Role of sarcolemmal KATP channels in cardioprotection against ischemia/reperfusion injury in mice
... the potassium equilibrium potential in ventricular cells of both WT and KO mice (Figure 2, a and ...outward current at 0 mV between ven- tricular cells isolated from WT ...the ATP-sensitive K ...
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Curcumin inhibits proliferation of gastric cancer cells by impairing ATP sensitive potassium channel opening
... has decreased remarkably in the past few years [22]. However, globally, gastric cancer is now the second lead- ing cause of mortality in malignant diseases [1]. The prognosis of patients with gastric cancer is poor, ...
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Regulation of vascular ATP-sensitive potassium channels by calcium and inflammatory mediators
... are sensitive to Ba^* and resistant to other classical K* channel inhibitors, which could explain these results (Prior et ...Ba^^ sensitive, voltage-independent current that was activated by cGMP but ...
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Activating Mutations in the Gene Encoding the ATP-Sensitive Potassium-Channel Subunit Kir6.2 and Permanent Neonatal Diabetes
... to ATP, which is predicted to result in gain of channel ...the ATP sensitivity of the resulting mixed population of heteromeric chan- nels was similar to that of the wild type, except at low ATP ...
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The involvement of ATP-sensitive potassium channels in novel forms of myocardial protection
... blocked HSP70 mRNA expression; no information was supplied for pinacidil or cromakalim. The sulphonylurea glipazide antagonised the inhibitory effects of the KCOs on c-fos, c-jun and HSP70 mRNA expression, indicating ...
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Functional cell biology and molecular pharmacology of ATP sensitive potassium channels
... intracellular potassium ion (K+) concentration that is twenty five times higher than the external K+ ...a potassium channel opens, an efflux of positive charge and an outward current ...for ...
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The pharmacology of three inwardly rectifying potassium Channels in neonatal rat cardiac myocytes.
... Action potential duration and activation of the ATP-sensitive K+ current in isolated guinea pig ventricular myocytes. Strong Voltage-Dependent Inward Rectification[r] ...
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Expression of ATP-sensitive potassium channels in human pregnant myometrium
... It seems that there is a functional regionalization in human myometrium during pregnancy and labour. The upper segment (US) region of the uterus maintains a relaxatory phenotype to accommodate the growing fetus ...
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GENE INTERACTIONS BETWEEN POTASSIUM-SENSITIVE AND POTASSIUM-RESISTANT MUTATIONS OF PARAMECIUM TETRAURELIA
... To be certain of this result the cross was done twice 5 months apart, and both times the same result was obtained (Table 2). This result cannot be due to segregation of li[r] ...
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The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes
... (ATP)-sensitive potassium (K ATP ) channel ...K ATP channel activity couples glucose metabolism to insulin secretion via cellular excitability and mutations in either KCNJ11 or ABCC8 ...
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Intracellular ATP can regulate afferent arteriolar tone via ATP sensitive K+ channels in the rabbit
... mM ATP and in a dose-dependent fashion by glibenclamide (10(-9) M to 10(-6) M), a specific antagonist of KATP ...of ATP, and this effect was also blocked by ...intracellular ATP levels can effect AA ...
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Conversion of amylase secreting rat pancreatic AR42J cells to neuronlike cells by activin A
... cytoplasmic free calcium concentration in response to depolarizing concentration of potassium. Moreover, activin-treated AR42J cells expressed mRNA for alpha 1 subunit of the neuroendocrine/beta cell-type ...
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ATP sensitive potassium channels mediate contraction induced attenuation of sympathetic vasoconstriction in rat skeletal muscle
... In our experiments, glibenclamide also attenuated active hyperemia, which is consistent with previous studies in the ca- nine diaphragm (35, 36) and hamster cremaster muscle (37). We therefore considered the possibility ...
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Glucose modulates rat substantia nigra GABA release in vivo via ATP sensitive potassium channels
... on ATP-sensitive potassium (KATP) ...of ATP by perfusion of 2-deoxyglucose with oligomycin inhibited GABA release by 44 +/- 8 and 45 +/- 11%, ...
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ATP-sensitive Potassium Channels and L-type Calcium Channels are Involved in Morphine-induced Hyperalgesia after Nociceptive Sensitization in Mice
... zation, which leads to an increase in locomotor response (Valjent et al., 2010). Therefore, an alternate possibility for decrease of analgesic effect of morphine after noci- ceptive sensitization may result from changes ...
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Effects of exogenous free radicals on electromechanical function and metabolism in isolated rabbit and guinea pig ventricle Implications for ischemia and reperfusion injury
... activated ATP-sensitive K+ channels, decreased the calcium current, and caused cell shortening by irreversibly inhibiting glycolytic and oxidative ...
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Modulation of pulmonary vasomotor tone in the fetus and neonate
... ), ATP- dependent (K ATP ), and several voltage-dependent (K V ) potassium channels have been identified on both pulmonary endothelial and vascular smooth muscle ...endothelial potassium ...
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Effects of Thrombin on the Potassium and ATP Content of Platelets
... In six experiments, twice washed platelets from 3-ml portions of plateletrich plasma were incubated at 370 C in Trisbuffered saline containing radioactive potassium K42 in addition to st[r] ...
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Blocking ATP-sensitive potassium channel alleviates morphine tolerance by inhibiting HSP70-TLR4-NLRP3-mediated neuroinflammation
... ABC: ATP-binding cassette; ASC: Apoptosis-associated speck-like protein; ATP: Adenosine triphosphate; BMDMs: Bone marrow-derived macrophages; CFTR: Cystic fibrosis transmembrane conductance regulator; CGRP: ...
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