autoimmune encephalomyelitis
The circumventricular organs participate in the immunopathogenesis of experimental autoimmune encephalomyelitis
... experimental autoimmune encephalomyelitis (EAE), immune cells migrate from the blood stream into the CNS parenchyma and into the cerebrospinal fluid (CSF) ...
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<p>Protective Effects of Leukadherin1 in a Rat Model of Targeted Experimental Autoimmune Encephalomyelitis (EAE): Possible Role of P47phox and MDA Downregulation</p>
... Background: Reactive oxygen and nitrogen species (ROS and RNS) are involved in pathologic mechanisms underlying demyelination and exacerbation in multiple sclerosis (MS) lesions. P47phox is the most important subunit of ...
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Secreted phospholipase A2 activity in experimental autoimmune encephalomyelitis and multiple sclerosis
... experimental autoimmune encephalomyelitis (EAE) models of MS suggest PLA2 enzymes are involved in the onset and genesis of this dis- ease ...the autoimmune response and EAE clinical ...
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The role of T cell subsets in experimental autoimmune encephalomyelitis
... Due to the complex environmental and genetic factors influencing MS, the pathogenesis of this disease is still poorly understood. In order to elucidate the causes and to develop new therapies, an animal model for MS was ...
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Translational utility of experimental autoimmune encephalomyelitis: recent developments
... complex autoimmune condition with firmly established genetic and environmental ...experimental autoimmune encephalomyelitis (EAE), has been instrumental in understanding immunity in general and ...
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Compensatory Neuroprotective Response of Thioredoxin Reductase Against Oxidative-Nitrosative Stress Induced by Experimental Autoimmune Encephalomyelitis in Rats: Modulation by Theta Burst Stimulation
... Cortical theta burst stimulation (TBS) structured as intermittent (iTBS) and continuous (cTBS) could prevent the progression of the experimental autoimmune encephalomyelitis (EAE). The interplay of brain ...
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Immunosuppressive activity of 13 cis retinoic acid and prevention of experimental autoimmune encephalomyelitis in rats
... Treatment with pharmacological concentrations of 13-cRA prevented active as well as passive transfer experimental autoimmune encephalomyelitis EAE and suppressed lymphocyte responsivenes[r] ...
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Anticoagulation with warfarin and rivaroxaban ameliorates experimental autoimmune encephalomyelitis
... Multiple sclerosis (MS) is an autoimmune inflammatory disease characterized by demyelination, axonal damage, and gliosis. Platelets were shown to promote central ner- vous system (CNS) inflammation [1, 2], and ...
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Bioluminescence in vivo imaging of autoimmune encephalomyelitis predicts disease
... Experimental autoimmune encephalomyelitis (EAE) is the most commonly used animal model to study multiple sclerosis (MS), a progressive paralytic disease character- ized by inflammation of the central ...
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Schubart, Anna (2002): Aspects of the Immunobiology of Myelin Oligodendrocyte Glycoprotein (MOG)-induced Experimental Autoimmune Encephalomyelitis (EAE). Dissertation, LMU München: Fakultät für Biologie
... Type I and II lesions show a striking resemblance to the lesions seen in certain models of experimental autoimmune encephalomyelitis (EAE), an animal model of MS initiated by an autoimmune response ...
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IL 23 produced by CNS resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis
... CNS-resident cells, in particular microglia and macrophages, are a source of inflammatory cytokines during inflammation within the CNS. Expression of IL-23, a recently discovered cytokine, has been shown to be critical ...
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CD28 independent induction of experimental autoimmune encephalomyelitis
... Activation of mature T lymphocytes requires antigen recognition and costimulatory signals, but the require- ments for T-cell anergy and apoptosis are more contro- versial. Earlier reports suggested that antigen recogni- ...
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A role for surface lymphotoxin in experimental autoimmune encephalomyelitis independent of LIGHT
... In studies using genetically deficient mice, a role for the lymphotoxin (LT) system in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) has remained controversial. Here, we have ...
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1,25 dihydroxyvitamin D3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis
... The hormone, 1,25-dihydroxyvitamin D3 (1,25-[OH]2-D3), inhibits lymphocyte activation in vitro. We studied the ability of the vitamin D metabolite to interfere in vivo with a primary T cell-mediated model of ...
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The Effect of Aqueous Extract of Tarragon on Clinical Symptoms and T Cell Differentiation in Experimental Autoimmune Encephalomyelitis
... Experimental autoimmune encephalomyelitis (EAE) has been widely used among various animal models to understand the immunopathology of ...the autoimmune disease by inhibition of the activity of other ...
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Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis
... Abstract: Bioactive lipids contribute to the pathophysiology of multiple sclerosis. Here, we show that lysophosphatidic acids (LPAs) are dysregulated in multiple sclerosis (MS) and are functionally relevant in this ...
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Modulation of experimental autoimmune encephalomyelitis by endogenous Annexin A1
... other autoimmune diseases, it is initiated by an uncontrolled T cell response to autoantigens presented in the context of MHC molecules of antigen presenting ...
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T cells in multiple sclerosis and experimental autoimmune encephalomyelitis
... are accompanied by the risk of life-threatening complica- tions [9]. This is partly a reflection of the global immuno- suppressive effects of these drugs. Efforts are now focused upon targeting Th17 cells and associated ...
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The pathogenesis of experimental autoimmune encephalomyelitis
... Thl cells have also been shown to play a role in the induction of antibody secretion from B cells, as Thlderived IFN-y induces B cells to secrete lgG2a in viral infections [116].. CD4 T [r] ...
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Angiogenesis in multiple sclerosis and experimental autoimmune encephalomyelitis
... allergic encephalomyelitis; ECM: Extacellular matrix molecule; EGF: Epidermal Growth Factor; ENOS: endothelial Nitric Oxide Synthetase; EPO: Erythropoietin; ER: Estrogen receptor; ET: Endothelin; GA: Glatiramer ...
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