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Autophagy Cancer Stem Cell

Role of autophagy in the maintenance and function of cancer stem cells

Role of autophagy in the maintenance and function of cancer stem cells

... in stem cell status has been identified within ...glioblastoma stem cells can differentiate towards neural and mesenchymal lineages(Ricci-Vitiani et ...Moreover, cancer cells may experience ...

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Autophagy regulates the stemness of cervical cancer stem cells

Autophagy regulates the stemness of cervical cancer stem cells

... analyzing autophagy and its involvement in CSC ...cervical cancer cell ...vical cancer cells have higher stemness marker expression and the tumorspheres contain more CSCs/progenitor cells than ...

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Cancer stem cell metabolism

Cancer stem cell metabolism

... of cell metabolism has evolved into an active area of research during the last decade, with a strong focus on glucose ...as autophagy, which makes them more resistant to nutrient deprivation and other ...

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Autophagy maintains the stemness of ovarian cancer stem cells by FOXA2.

Autophagy maintains the stemness of ovarian cancer stem cells by FOXA2.

... between autophagy and stemness [8].Autophagy involves the sequestration of cytoplasmic components within a double-membraned vesicle, and subsequent fusion with lysosomes to generate autolysosomes, in which ...

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Autophagy regulates the stemness of cervical cancer stem cells

Autophagy regulates the stemness of cervical cancer stem cells

... To elucidate the basal and starvation-stimulated autophagic capacities of cervical CSCs, we used an in vitro system in which primitive mammary CSCs can be propagated in cul- ture as floating spherical colonies termed ...

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The Changes of Autophagy in Pancreatic Stem
Cells for Patients with Pancreatic Ductal Cancer

The Changes of Autophagy in Pancreatic Stem Cells for Patients with Pancreatic Ductal Cancer

... in cell number due to the disruption of the delicate balance between cell proliferation and ...circumstances, autophagy functions as a safeguard mechanism that promotes uncontrolled cancer ...

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Oncolytic viruses as immunotherapy: progress and remaining challenges

Oncolytic viruses as immunotherapy: progress and remaining challenges

... include cancer stem cell (CSC) lysis and autophagy, modulation of innate and adaptive immunity, immunogenic cell death (ICD), OV transgene arming for improved clinical efficacy, inhi- ...

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Cancer stem cell metabolism

Cancer stem cell metabolism

... of cell metabolism has evolved into an active area of research during the last decade, with a strong focus on glucose ...as autophagy, which makes them more resistant to nutrient deprivation and other ...

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Crosstalk between the Warburg effect, redox regulation and autophagy induction in tumourigenesis

Crosstalk between the Warburg effect, redox regulation and autophagy induction in tumourigenesis

... by cancer stem cells also known as progenitor-like cells or stem cell-like cells [94, ...Furthermore, cancer recurrence and subsequent metastasis are largely due to disseminated tumour ...

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Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells

Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells

... cells. Autophagy has a context-dependent role in initiation, development and progression of cancer [22, ...23]. Autophagy suppresses malignant transformation by different mechanisms such as ...

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Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells

Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells

... of autophagy by bafilomycin in- duces iPSC ...activates autophagy in concentration-dependent and time-dependent manners and attenuate bafilomycin toxicity in ...induces cell detachment and forma- ...

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(+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death

(+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death

... single cell suspension were mixed in a microtube and incubated for 20 minutes at room temperature in the ...Muse cell analyzer, and 5,000 cell events were collected for each ...

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Original Article Trichosanthin inhibits human ovarian cancer cells growth due to apoptosis and autophagy

Original Article Trichosanthin inhibits human ovarian cancer cells growth due to apoptosis and autophagy

... apoptotic cell death. Autophagy has recently gained attention because of its paradoxical roles in cancer cell survival and death ...that autophagy can function as a protective mechanism ...

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Cyclin D1 affects epithelial–mesenchymal transition in epithelial ovarian cancer stem cell-like cells

Cyclin D1 affects epithelial–mesenchymal transition in epithelial ovarian cancer stem cell-like cells

... adenocarcinoma cell line 3AO were able to proliferate normally under low serum conditions, suggesting that CD24 - cells possess much stronger proliferative ability than parental and CD24 + ...that cancer ...

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Estrogen receptor β inhibits breast cancer cells migration and invasion through CLDN6-mediated autophagy

Estrogen receptor β inhibits breast cancer cells migration and invasion through CLDN6-mediated autophagy

... (Fig. 2 a, b). Therefore, this E2-induced effect was not ERα- dependent, and we focused our attention on ERβ. To dem- onstrate that the increased expression of CLDN6 was medi- ated by ERβ, we knocked down ERβ in ...

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NOTCH1 is a poor prognostic factor for breast cancer and is associated with breast cancer stem cells

NOTCH1 is a poor prognostic factor for breast cancer and is associated with breast cancer stem cells

... was observed between the presence of NOTCH1 in tumor tissue and other clinicopathologic features, such as tumor size, regional lymph nodes, recurrence, ER, PR, or HER2, nor was there any statistical association between ...

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Brca1 breast tumors contain distinct CD44+/CD24  and CD133+cells with cancer stem cell characteristics

Brca1 breast tumors contain distinct CD44+/CD24 and CD133+cells with cancer stem cell characteristics

... that cancer-initiating cells sorted from established cell lines or primary tumors form sphe- roids when plated in semisolid support or serum-free media supplemented with epidermal grwoth factor and basic ...

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Targeting autophagy in cancer management – strategies and developments

Targeting autophagy in cancer management – strategies and developments

... Notes: mTOR is one of the most important regulators of autophagy. mTOR and other pathways including cAMP, LKB, AMPK, and PKA merge at mTORC1. AMPK inhibits mTORC1 by direct interaction or by indirect activation of ...

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Effect of overexpression of Oct4 and Sox2 genes on the biological and oncological characteristics of gastric cancer cells

<p>Effect of overexpression of Oct4 and Sox2 genes on the biological and oncological characteristics of gastric cancer cells</p>

... adult stem cells. The concept of cancer stem cells (CSCs) was proposed in the last ...that cancer cells can be categorized into many types, ranging from malignant CSCs, which have unlimited ...

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The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo

The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo

... as cell lysates, and the protein concentration of the cell lysates was determined by a BCA protein assay kit (Pierce Biotechnology ...USA). Cell lysates containing equal amounts of protein were ...

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