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Autosomal dominant polycystic kidney disease (ADPKD)

Hyperuricemia and deterioration of renal function in autosomal dominant polycystic kidney disease

Hyperuricemia and deterioration of renal function in autosomal dominant polycystic kidney disease

... ADPKD: Autosomal dominant polycystic kidney disease; CKD: Chronic kidney disease; CKD-EPI: Chronic kidney disease epidemiology collaboration; CT: Computed ...

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Magnetic resonance imaging is effective for evaluating the therapeutic effect of tolvaptan on total kidney volume in patients with autosomal dominant polycystic kidney disease

Magnetic resonance imaging is effective for evaluating the therapeutic effect of tolvaptan on total kidney volume in patients with autosomal dominant polycystic kidney disease

... Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disease characterized by the progressive growth of multiple cysts in both ...both kidney enlargement ...

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Familial Arachnoid Cysts in Association With Autosomal Dominant Polycystic Kidney Disease

Familial Arachnoid Cysts in Association With Autosomal Dominant Polycystic Kidney Disease

... ABSTRACT. Autosomal dominant polycystic kidney disease (ADPKD) is a systemic disorder well-known for its association with intracranial ...tosomal dominant polycystic ...

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Total kidney and liver volume is a major risk factor for malnutrition in ambulatory patients with autosomal dominant polycystic kidney disease

Total kidney and liver volume is a major risk factor for malnutrition in ambulatory patients with autosomal dominant polycystic kidney disease

... Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease, and can progress to end-stage renal disease (ESRD) as ...

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Modelling the long-term benefits of tolvaptan therapy on renal function decline in autosomal dominant polycystic kidney disease: an exploratory analysis using the ADPKD outcomes model

Modelling the long-term benefits of tolvaptan therapy on renal function decline in autosomal dominant polycystic kidney disease: an exploratory analysis using the ADPKD outcomes model

... ist, became the first pharmacological agent to receive regulatory approval for the management of ADPKD. Since its initial approval in Japan, tolvaptan has subsequently received marketing authorisation for the treatment ...

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A systematic review of the predictors of disease progression in patients with autosomal dominant polycystic kidney disease

A systematic review of the predictors of disease progression in patients with autosomal dominant polycystic kidney disease

... ADPKD autosomal dominant polycystic kidney disease, Alb/Cr albumin/creatinine ratio, ARB angiotensin receptor blocker, BL baseline, BMI body mass index, BP blood pressure, BSA body ...

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STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease.

STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease.

... Autosomal dominant polycystic kidney disease (ADPKD) leads to renal failure. The hallmark of ADPKD is increased epithelial proliferation, which has been proposed to be due to atypical ...

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A Study on Clinical Profile and Extrarenal Manifestations of Autosomal Dominant Polycystic Kidney Disease

A Study on Clinical Profile and Extrarenal Manifestations of Autosomal Dominant Polycystic Kidney Disease

... The findings of early-onset endothelial dysfunction mentioned above were confirmed by a study that reported decreased coronary flow velocity reserve—which represents the capacity of the coronary circulation to dilate ...

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Autosomal dominant polycystic kidney disease in a family with mosaicism and hypomorphic allele

Autosomal dominant polycystic kidney disease in a family with mosaicism and hypomorphic allele

... ADPKD in the patient was first diagnosed on ultra- sound at the age of 20. At this age he suffered from re- peated renal colic caused by urate concrements. The stones passed spontaneously after hydration. He was on ...

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Real world costs of autosomal dominant polycystic kidney disease in the Nordics

Real world costs of autosomal dominant polycystic kidney disease in the Nordics

... normal kidney func- tion, found that these patients added a sizable economic burden to the health care system relative to the general population ...chronic kidney disease (CKD) patients, were found ...

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Urine proteome of autosomal dominant polycystic kidney disease patients

Urine proteome of autosomal dominant polycystic kidney disease patients

... Our results provide the first step of the analysis, spe- cific DPL proteins of interest should be now verified by a targeted analysis on non-pooled samples on much wider sample sets. Moreover, the specificity of these ...

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Autosomal dominant polycystic kidney disease: updated perspectives

<p>Autosomal dominant polycystic kidney disease: updated perspectives</p>

... cystic disease (class 1) and is strati fi ed into fi ve classes (A, B, C, D, E) based on the growth rates ...progressive disease in the majority of patients with ADPKD, ...

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A model to predict disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD): the ADPKD Outcomes Model

A model to predict disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD): the ADPKD Outcomes Model

... progression, were simulated. Modelled trajectories of eGFR and TKV in early-stage ADPKD patients were val- idated against data derived from CRISP I [18] and HALT-PKD Study A [19], while model-predicted disease ...

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Risk of intracranial hemorrhage associated with autosomal dominant polycystic kidney disease in patients with end stage renal disease

Risk of intracranial hemorrhage associated with autosomal dominant polycystic kidney disease in patients with end stage renal disease

... cerebrovascular disease includ- ing cerebrovascular accident (CVA) and transient ischemic attack (TIA), the risk of ICH among ADPKD patients still remained significant with an AHR ...heart disease, ...

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Urine Fetuin A is a biomarker of autosomal dominant polycystic kidney disease progression

Urine Fetuin A is a biomarker of autosomal dominant polycystic kidney disease progression

... that polycystic mouse kidneys induced by targeted deletion of Pkd1 or Bicc1 as well as the urine of ADPKD patients contain elevated levels of ...bone, kidney, and respiratory and cardiovas- cular systems ...

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Chronic asymptomatic pyuria precedes overt urinary tract infection and deterioration of renal function in autosomal dominant polycystic kidney disease

Chronic asymptomatic pyuria precedes overt urinary tract infection and deterioration of renal function in autosomal dominant polycystic kidney disease

... the disease severity, we followed up patients more frequently after overt UTI episodes or when they needed acute managements such as high blood pres- sure or new onset ...

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Management of Autosomal Dominant Polycystic Kidney Disease (ADPKD) During Pregnancy: Risks and Challenges

<p>Management of Autosomal Dominant Polycystic Kidney Disease (ADPKD) During Pregnancy: Risks and Challenges</p>

... Management of early stages of ADPKD and CKD generally is discussed in more detail elsewhere. 17 The management of many aspects of ADPKD including genetic testing, cyst pain, and non-renal manifestations is also outlined ...

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Autosomal dominant polycystic kidney disease with ectopic unilateral multicystic dysplastic kidney

Autosomal dominant polycystic kidney disease with ectopic unilateral multicystic dysplastic kidney

... sporadic disease condition of abnormal metanephric ...total kidney func- tion of many subjects with MCDK could be well- maintained ...the kidney structure destruc- tion by the continuous cyst growth ...

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Functional polycystin 1 dosage governs autosomal dominant polycystic kidney disease severity

Functional polycystin 1 dosage governs autosomal dominant polycystic kidney disease severity

... in disease, but the available data are limited and somewhat contradictory ...mild disease in old age, while conditional models do not reflect the disease devel- opment in human ADPKD due to the loss ...

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Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease

Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease

... Increased expression of Myc in human and rodent PKD is asso- ciated with high rates of proliferation and apoptosis, despite increased expression of the antiapoptotic factor Bcl-2 and unaltered or reduced expression of ...

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