Axonal Sprouting
The role of metallothionein I/II in promoting axonal sprouting in both central nervous system and peripheral nervous system
... the axonal sprouting response after injury has been demonstrated to be independent of upregulation of cytoskeletal proteins in the cell ...regenerative sprouting is initiated, as well as the ...
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Microglial depletion under thalamic hemorrhage ameliorates mechanical allodynia and suppresses aberrant axonal sprouting
... Branch formation from thalamocortical neurons into layer 4 of the S1 after TH. In a recent study, genetic abla- tion of the VB in the developmental stage resulted in anatomical and functional rewiring of the afferent ...
15
Transplantation of canine olfactory ensheathing cells producing chondroitinase ABC promotes chondroitin sulphate proteoglycan digestion and axonal sprouting following spinal cord injury
... efficient axonal repair and limit the thera- peutic potential of ...of sprouting within the corticospinal tract rostral to the lesion and an increase in the number of corticospinal axons caudal to the ...
19
Using Gene Knockout and Transgenic Approaches to Evaluate in vivo Functions of CNS Regeneration Inhibitors: How Important is Nogo?
... some non-Nogo growth inhibitory factor is expressed increasingly with age (Woolf, C. 2003). However, any implication of this in human adult CNS lesions remains unknown (Woolf, C. 2003). Therefore, we propose that the ...
27
The extracellular environment of the CNS : influence on plasticity, sprouting, and axonal regeneration after spinal cord injury
... greater axonal growth and sprouting of CST and raphespinal tract axons and improved locomotion were observed after SCI compared to single or double knockouts ...limited axonal sprouting and ...
19
Injury induced plasticity in primary neuronal culture and the mature brain
... post-injury sprouting, mature cultures were injured using an established scratch model of ...substantial axonal sprouting at 24 hours post- ...the axonal sprouting response by ...
146
Morphological plasticity of postsynaptic neurones in reactive synaptogenesis
... In this case, since dendritic atrophy caused by visual deafferentation was accompanied neither by axonal sprouting nor by axonal loss of the main surviving cortical afferents, the net re[r] ...
10
Spinal Cord Regeneration: Ready, Set, Nogo
... We next began investigating how interrupting the Nogo/NgR receptor interaction could enhance spinal cord injury using a Nogo-66 antagonist peptide, NEP1-40. The NEP1-40 antagonist peptide does not trigger growth cone ...
7
Clinical and electrophysiological features of post-traumatic Guillain-Barré syndrome
... presentation and electrodiagnostic data. Cranial nerve involvement, such as that associated with bifacial weak- ness, and dysautonomia are uncommon in critical illness polyneuropathy. In these patients the degree of ...
7
Neutrophil–lymphocyte ratio and response to plasmapheresis in Guillain–Barré syndrome: a prospective observational study
... patients with a poor outcome (p = 0.01). In addition, our results revealed a significant positive correlation between the initial NLR values and the mean Hughes disability scale scores of both types of patients at ...
6
Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis
... Two major observations are evident following early and late tolerisation. Firstly effective suppression of clinical and immunological measures of inflammation even after the first clinical event, although beneficial and ...
17
Comparison of 2D and 3D realistic models of white matter microstructure
... The magnetic susceptibility of myelin affects both the magnitude and phase of the Gradient Recalled Echo (GRE) signal. Therefore, studying the signal using re- alistic models of white matter (WM) microstructure could ...
68
Two Modes of the Axonal Interferon Response Limit Alphaherpesvirus Neuroinvasion
... body, axonal IFN- treatment restricted both PRV retrograde transport and infection ...However, axonal IFN- ␥ treatment of KO neurons still reduced the percentage of moving PRV particles to ...
13
Axonal and Transynaptic Spread of Prions
... altered axonal transport ...Furthermore, axonal transport of prions may not be the rate-limiting step that leads to a lengthening of the incubation period when these pathways are ...
16
Wesolowski, Marta (2018): In vivo analysis of calcium-initiated axon degeneration in an animal model of MS. Dissertation, LMU München: Graduate School of Systemic Neurosciences (GSN)
... including axonal degeneration and ...approach, axonal disintegration in EAE lesions could be observed in ...this axonal degeneration is in some degree reversible, thereby revealing a therapeutic ...
108
Axonal Transport: A Constrained System
... Long-distance intracellular axonal transport is predominantly microtubule- based, and its impairment is linked to neurodegeneration. Here we review recent theoretical and experimental evidence that suggest that ...
5
Abnormal Axial Diffusivity in the Deep Gray Nuclei and Dorsal Brain Stem in Infantile Spasm Treated with Vigabatrin
... and axonal changes could occur in infants exposed to vigabatrin or whether myelin vacuolation represents early changes and axonal changes developed ...
5
Diffusional kurtosis imaging of the corpus callosum in autism
... Traditional diffusion tensor imaging (DTI) is based on a simplified Gaussian distribution of water diffusion that is problematic when encountering complex microscopic organizations in which diffusion may be non-Gaussian. ...
12
S1P1 inhibits sprouting angiogenesis during vascular development
... 1995). Sprouting angiogenesis plays a central role in the remodeling process by forming new vascular loops, which expand the vascular ...angiogenic sprouting (Adams and Alitalo, 2007; Eilken and Adams, ...
11
Axonal and synaptic pathology in Alzheimer’s disease
... I found a progression of dystrophic changes in NF-ir neurites from early to end-stage human AD, which was closely mimicked in both APP/PS1 and Tg2576 transgenic mice lines. There was an increase in the number of ...
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